Granular Cell Tumour of the Deltoid Muscle: A Rare Entity in the Musculoskeletal System

  • Chetan Sudhakar Chaudhari Assistant Professor,Dept of Pathology LTMMC & LTMGH,Sion,Mumbai
  • Manisha Khare Professor,Dept of Pathology LTMMC & LTMGH,Sion,Mumbai
  • Shailesh Vartak Associate Professor,Dept of Pathology LTMMC & LTMGH,Sion,Mumbai
  • Urmi Chakravarty-Vartak Associate Professor,Dept of Pathology LTMMC & LTMGH,Sion,Mumbai
  • Prashant Kumavat Assistant Professor,Dept of Pathology LTMMC & LTMGH,Sion,Mumbai
Keywords: Deltoid muscle, Granular cell tumour, Musculoskeletal system


Granular Cell Tumours are a rare mesenchymal soft tissue tumours that arise throughout the body and are believed to be of neural origin.They are so named because composition of characteristic nesting pattern of polyhedral cells with abundant granular eosinophilic cytoplasm.They often present as asymptomatic, slow-growing, benign, solitary lesions but may be multifocal. 1-2% of cases are malignant and can metastasise. Granular cell tumour commonly occurs in head and neck, with a particular predisposition for the tongue. The authors describe an unusual location of this tumour within the deltoid muscle of the arm. A 55 Year old female presented with mass and tenderness at the distal end of deltoid site since 2 years. MRI showed a mass within deltoid muscle, 5x3x2 cm. Intraoperative frozen and later surgically resceted specimen showed histopathological features of benign granular cell tumour,at unusal site and a rare entity in the musculoskeletal system, witin deltoid muscle.


1. Abrikossoff A. Über myome, ausgehend von der quergestreiften willkürlichen Muskulatur.Virch Arch 1926, 260:215-233.

2. Becelli R, Perugini M, Gasparini G, Cassoni A, Fabiani F. Abrikossoff’s tumor. J Craniofac Surg 2001, 12:78-81.

3. Payne-James JJ, Watkins RM. Granular cell tumour (myoblastoma): two cases and a review of the literature. Br J Clin Pract 1990;44:334-362

4. Rejas RAG, Campos MS, Cortes ARG, Pinto DS, de Sousa SCOM: The neural histogenetic origin of the oral granular cell tumor: an immunohistochemical evidence. Med Oral Patol Oral Cir Bucal 2011, 16:e6-10.

5. Zangari F, Trombelli L, Calura G. Granular cell myoblastoma. Review of the literature and report of a case. Minerva Stomatol 1996;45:231-237.

6. Tsuchida T, Okada K, Itoi E, Sato T, Sato K. Intramuscular malignant granular cell tumor. Skeletal Radiology.1997; 26:116–121.

7. Lack EE, Worsham GF, Callihan MD. Granular cell tumor.A clinicopathologic study of 110 patients. Journal of Surgical Oncology. 1980;13(4):301–316.

8. Blacksin MF, White LM, Hameed M, Kandel R, Patterson FR, Benevenia J. Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation. Skeletal Radiology, 2005; 34(10):625–631.

9. Cadotte M. Malignant granular cell myoblastoma. Cancer, 1974;33:1417–1422.

10. Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. American Journal of Surgical Pathology. 1998; 22: 779–794.
Case Report

Most read articles by the same author(s)