T-cell Rich Large B-cell Lymphoma: A rare variant of diffuse Large B-cell Lymphoma

  • Mangal Motilal Pandure Rural Medical College, Loni. Tal: Rahata, Dis:Ahmednagar, StateMaharashtra - 413736
  • Ravindra Karle
  • Surykant Dongre
  • Varsha Deshpande
Keywords: Non Hodgkin’s Lymphoma-extranodal, Difuse large b cell Lymphoma, T cell rich B cell lymphoma, T cell histiocyte rich B cell lymphoma


T-Cell Rich-B cell Lymphoma (TCRBCL) is separately defined by World Health Organisation(WHO), it is a subtype of Diffuse Large B cell Lymphoma (DLBCL). It is an aggressive disorder treated same as that of DLBCL. But some times it may not respond to therapy and it has poor prognosis. It requires careful histopathological examination and immunohistochemistry (IHC) for confirmation. We reported a rare case of subcutaneous T cell rich B cell lymphoma, which is confirmed by IHC which shows CD20 and CD3 marker positive.


1. Shiyong Li, Constance A Griffin, Risa B Mann, Michael J Borowitz. Primary Cutaneous T-Cell—Rich B-Cell Lymphoma: Clinically Distinct from Its Nodal Counterpart? Modern Pathology 2001;14:10-13.

2. Pitttaluga S, Elaine S, Jaffe. T-cell/histiocyte-rich B-cell lymphoma. Haematologica. 2010; 95:352-356.

3. Bheemanagouda GP, Hallikeri KS, Krishna RP. T-Cell-Rich Diffuse Large B-cell Lymphoma Presenting as an Intraosseous Maxillary Neoplasm. World Journal of Dentistry 2011; 2:53-55.

4. Jun Wang, Nora C. J. Sun, Sanford M. Weinstain.,RinoldoCanalis. Primary T-Cell –Rich B-Cell Lymphoma of the EthmoidSinus. Arch Pathol Lab Med 2000; 124:1213-1216.

5. Jeremy S. Abramson. T-Cell/Histiocyte Rich B-Cell Lymphoma: Biology, Diagnosis and Management. The Oncologist 2006; 11(4):384-392.

6. Koksal AR, Alkin H, Ergun M, Boga S, Mehmet Bayram, Canan Alkim et.al. First case of T-cell/histiocyte-rich B-cell lymphoma presenting with duodenal obstruction. Libyan Journal Med 2013;8:22955

7. Olaniyi JA, Oluwasola AO, Ibijola A. Therapy Outcome of a T-Cell-Rich-B-Cell lymphoma (TCRBCL) Patient with R-CHOP in Ibadan, Nigeria : a case report. Mediterranaean Journal of Haematology And Infectious Disease 2011; 3 open Journal System.

8. Chung-Che Chang, Ellen Bunyi-Teopengco, Camellia Eshoa, Christhoper R Chitamber, Bal Kapalath.CD5+ T-Cell/Histiocyte_Rich Large B-Cell Lymphoma. Modern Pathology 2002; 15: 1051-7.

9. Jose Rodriguez J, WC Pugh, Cabanillas F. T- Cell – Rich B- cell lymphoma. Blood 1993;82(5): 1586-1589.

10. Shahabuddin D, Raghuveer CV. Reed-Sternberg-like cells in T- cell rich B-cell lymphoma: a diagnostic dilemma. Indian Journal of PatholMicrobiol 2003; 46(1):55-56.

11. Peter Van Loo, Thomas Tousseyn, Vera Vanhentenrijk, Daan Delabie, Agnieszka Maleka. T-cell/histiocyte –rich large B-cell lymphoma shows transcriptional features suggestive a tolerogenic host immune responce.Haematologica 2010; 95:440-448.

12 R C Gatter, R A Warnke. Diffuse Large B cell Lymphoma.World Health Organisation Classification of Tumours. Pathology and Genetics. Tumors of hemopoietic and lymphoid tissue. Third edition . Place- Lyon.Published by IARC press,, International Agency for research on Cancer. 2001:173.

13 Jhon K C Chan. Tumours of Lymphoreticularsystem. Christopher D. M. Flecher. Tumours of lymphoreticular system .Diagnostic Histopathology of Tumors. Third Edition. Vol 2.Place- Philadelphia. Published by Churchill Livingstone ELSVIER. 2007: page 1204.

14 Thomas J. Cummings, Timothy T. Stenzel, Gordon Klintworth, Glenn J Jaffe. .T-Cell—Rich Large B-Cell Lymphoma. Arch Pathol Lab Med. 2005;129:1050-1053.
Case Report