Premalignant Lesions of Prostate and Its Association with Nodular Hyperplasia and Carcinoma of Prostate: A Histomorphological Study

  • Rajeshwari K Kumbar Assistant professor Department of pathology ACPM medical college Dhule
  • Karibasappa GN
  • N V Dravid
  • Ashish Patil
Keywords: histomorphology, premalignant, prostatic lesions.


Background: Identification of premalignant proliferative changes has gained importance for early diagnosis of prostatic carcinoma. In clinical practice knowing the frequency of a prostatic carcinoma diagnosed on repeat biopsies would aid primary treating physicians regarding their decisions in suspicious cases.Aims and Objectives: 1. To identify the histomorphological features of premalignant lesions of prostate. & 2. To know the association of premalignant lesion with benign and malignant lesions of prostate.Methods: This descriptive study was performed in the department of pathology during the study period of six years (2009-2015).  A total of 1,023 prostatic biopsies were studied for the presence and association of premalignant conditions of prostate. Statistical analysis was done using SPSS 17.0.Results: A total of 385 (37.63 %) were diagnosed as premalignant lesions of prostate. High grade prostatic intraepithelial neoplasia (HGPIN) constituted 71.6% of the cases followed by proliferative inflammatory atrophy (PIA) and atypical adenomatous hyperplasia (AAH) in 15.06% and 13.2% of the cases respectively.Conclusion: HGPIN and PIA showed strong association with carcinoma and AAH showed weaker association with carcinoma of prostate. Hence the histomorphological diagnosis of HGPIN, PIA should be highlighted in the biopsies by the pathologist and advised for repeat biopsy of the entire gland, irrespective of clinical, biochemical and radiological findings. 


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