Sclerosing stromal tumour of ovary: A case study with the review of literature

  • Vijay Kumar Jha Institute Of Medical Sciences Banaras Hindu University India
  • Alka Rai Heritage Institute of Medical Sciences, Varanasi, India
  • Mohan Kumar Institute Of Medical Sciences, Banaras Hindu University, Varanasi, India
  • Shivi Jain Institute Of Medical Sciences, Banaras Hindu University, Varanasi, India
  • Madhu jain Institute Of Medical Sciences, Banaras Hindu University, Varanasi, India
Keywords: Sclerosing stromal tumour, sex cord stromal tumour, ovary, vascular proliferation, immunohistochemistry

Abstract

Sclerosing stromal tumour of ovary is a rare and distinct type of sex cord stromal tumours with benign course and excellent prognosis. It affects mostly young females in their second and third decade of life. Nearly all the reported cases of sclerosing stromal tumour of ovary are unilateral with menstrual irregularities, pain abdomen and lower abdominal mass as commonest clinical presentations. Most of the cases are hormonically inactive, however, hormone production has been documented in various studies. Histopathology and IHC confirms the diagnosis. Surgical excision is the treatment of choice. No recurrence has been reported yet. We are describing a histopathologically confirmed case of a young girl who presented with complaints of menorrhagia and pain abdomen. Radiological examination and peroperative findings raised the suspicion of malignancy. It is important to consider sclerosing stromal tumour in young females presenting with complex ovarian mass.    

Author Biographies

Vijay Kumar Jha, Institute Of Medical Sciences Banaras Hindu University India
Senior ResidentDepartment Of Pathology
Alka Rai, Heritage Institute of Medical Sciences, Varanasi, India
Senior resident, Deptt. Of Obstetrics and Gynecology
Mohan Kumar, Institute Of Medical Sciences, Banaras Hindu University, Varanasi, India
Professor and Head, Deptt. Of Pathology
Shivi Jain, Institute Of Medical Sciences, Banaras Hindu University, Varanasi, India
Senior resident, Deptt. Of Radiodiagnosis and Imaging
Madhu jain, Institute Of Medical Sciences, Banaras Hindu University, Varanasi, India
Professor and Head, Deptt. Of Obstetrics and Gynecology

References

[1] Peng HH, Chang TC, Hsueh S. Sclerosing stromal tumor of ovary. Med J 2003;26:444-8.

[2] Ozdemir O, Sari ME, Sen E, Kurt A, Ileri AB, Atalay CR. Sclerosing stromal tumour of the ovary: A case report and the review of literature. Niger Med J 2014;55:432-7

[3] Kaygusuz EI, Cesur S, Cetiner H, Yavuz H, Koc N. Sclerosing stromal tumour in young women: Clinicopathologic and immunohistochemical spectrum. J Clin Diagn Res. 2013;7:1932–5.

[4] Akbulut M, Colakoglu N, Soysal ME, and Duzcan SE. “Sclerosing stromal tumor of the ovary: report of a case and review of the literature,” Agean pathology journal, 2004;1:84-89.

[5] Tiltman AJ. Sclerosing stromal tumor of the ovary. Int J Gynecol Pathol. 1985;4:362–69.

[6] Kawauchi S, Tsujı T, Kaku T, Kamura T, Nakano H, Tsuneyoshi M. Sclerosing stromal tumor of the ovary: a clinicopathologic, immunohistochemical, ultrastructual and cytogenetic analysis with special reference to its vasculature. Am J Surg Pathol. 1998;22:83–92.

[7] Cashell AW, Cohen ML. Masculinizing slerosing stromal tumor of the ovary during pregnancy. Gynecol Oncol. 1991;43:281–85.

[8] Liang YF, Zeng JC, Ruan JB, Kang DP, Wang LM, Chen C, JF Xu. Ovarian sclerosing stromal tumor in a young woman with ectopic pregnancy: Clinical, pathological, and immunohistochemical studies. Int J Clin Exp Pathol. 2013;7:456–9.

[9] Lam RMY, Geittmann P. Sclerosing stromal tumor of the ovary: a light, electronmicroscopic and enzyme histochemical study. Int J Gynecol Petrol. 1998;7:280–90.

[10] Ismail SM, Walker SM. Bilateral virilizing sclerosing stromal tumors of the ovary in a pregnant woman with Gorlin’s syndrome: implications for pathologenesis of ovarian stromal neoplasms. Histopathology.1990;17:159–63.

[11] Lifschitz-Mercer B, Open M, Kushnir I, Jacob N, Czernobilsky B. Hyaline globules and progesterone receptors in an ovarian sclerosing stromal tumor. Histopathology. 1995;27:195–97.

[12] Kostopoulou E, Moulla A, Giakoustidis D, Leontsini M. Sclerosing stromal tumor of the ovary: immunohistochemical and cytogenetic analyses of three cases. Eur J Gynaecol Oncol. 2004;25(2):257–60.

[13] Lopes JM, Seruca R, Hall AP, Branco P, Castedo SM. Cytogenetic study of a sclerosing stromal tumor of the ovary. Cancer Genet Cytogenet. 1990;49:103–6.
Published
2016-02-24
Issue
Vol 3 No 1 (2016)
Section
Case Report

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).