Non-leukemic granulocytic sarcoma presenting as multiple skin nodules: A rare case report

  • Pallavi Agrawal M.D., DNB, PDCC (Neuropathology) Department of Pathology, Postgraduate Institute of Medical Education & Research, Sector 12, Chandigarh 160012, India.
  • Narender Kumar Assistant Professor, Department of Haematology, Postgraduate Institute of Medical Education & Research, Sector 12, Chandigarh 160012, India
  • Deepak Bansal Additional Professor, Hematology-Oncology Division of Department of Pediatrics, Postgraduate Institute of Medical Education & Research, Sector 12, Chandigarh 160012, India.
  • Raje Nijhawan Professor in the Department of Cytology and Gynaecological Pathology, Postgraduate Institute of Medical Education & Research, Sector 12, Chandigarh 160012, India
Keywords: Bone marrow, fine needle aspiration cytology, flow-cytometry examination, non-leukemic granulocytic sarcoma

Abstract

Granulocytic sarcoma (GS) is a localized lesion comprising of immature granulocytes, monocytes, or both; involving extramedullary sites. GS with no evidence of leukemia (non-leukemic GS) is a very rare. Here we report a 10 year old male child who presented with facial and back swelling which was subsequently diagnosed as non-leukemic GS by flow-cytometry (FCM) examination on aspirated material.

References

1. Meis JM, Butler JJ, Osborne BM, Manning JT. Granulocytic sarcoma in nonleukemic patients. Cancer 1986; 58: 2697–709.

2. Yamauchi K, Yasuda M. Comparison in treatments of nonleukemic granulocytic sarcoma: Report of two cases and a review of 72 cases in the literature. Cancer 2002; 94:1739–46.

3. King A. A case of chloroma. Monthly J Med 1853; 17: 97.

4. Rodríguez Guerrero JM, Martín Hidalgo JR, Alonso Alejandro E, Pérez Ríos N, Roussel J, Rodríguez Pardo F et al. Granulocytic sarcoma (chloroma) of small bowel: an infrequent cause of intestinal obstruction. Gastroenterol Hepatol 2003; 26: 347–50.

5. Bénet C, Gomez A, Aguilar C, Delattre C, Vergier B, Beylot- Barry M, et al. Histologic and immunohistologic characterization of skin localization of myeloid disorders: a study of 173 cases. Am J Clin Pathol 2011;135: 278–290.

6. Audouin J, Comperat E, Le Tourneau A, Camilleri-Broët S, Adida C, Molina T et al. Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis. Int J Surg Pathol. 2003; 11: 271-82.

7. Neiman RS, Barcos M, Berard C, Bonner H, Mann R, Rydell RE et al. Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. Cancer 1981; 48: 1426-37.

8. Spahr J, Behm FG, Schneider V. Preleukemic granulocytic sarcoma of cervix and vagina: initial manifestation by cytology. Acta Cytol 1982; 26: 55-60.

9. Krause JR. Granulocytic sarcoma preceding acute leukemia: a report of six cases. Cancer 1979; 44: 1017-21.

10. Lan TY, Lin DT, Tien HF, Yang RS, Chen CY, Wu K. Prognostic factors of treatment outcomes in patients with granulocytic sarcoma. Acta Haematol. 2009; 122: 238-46.
Published
2016-02-25
Section
Case Report