Non-Hodgkin Lymphoma of cervix: an unusual presentation
Keywords:
Non-Hodgkin Lymphoma, CD 20, cervix, Diffiuse large B cell.
Abstract
Non-Hodgkin Lymphoma is diverse and often subdivided into diffuse large B-cell lymphoma, peripheral T-cell lymphoma, Burkitt’s lymphoma, mantle cell lymphoma and AIDS-related lymphoma. Primary lymphoma involving the uterine cervix is very rarely encountered. We are presenting here a case with post menopausal bleeding with provisional diagnosis of poorly differentiated cervical carcinoma. Radical hysterectomy (type II) with bilateral pelvic lymph node dissection was done . Specimen is sent for histopathological examination and it was reported as diffuse round cells proliferating in an apparently unorganized fashion, with hyperchromatic nuclei and scanty cytoplasm and prominent nucleoli with possibility of poorly differentiated carcinoma or Non-Hodgkin lymphoma involving cervix. Immunohistochemistry study showed expression of CD 20 and negative expression of CD3 there by confirmed the diagnosis of diffuse large B cell type (DLBCL) Non-Hodgkin lymphoma of uterine cervix. The incidence of extranodal Non-Hodgkin Lymphoma is increasing. So, Clinicians and pathologists should be aware of this diagnosis in patients presenting with abnormal vaginal bleeding, and negative papanicolaou test.References
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2. Komaki R, Cox JD, Hansen RM, Gunn W, Greenberg M. Malignant lymphoma of the uterus and cervix. Cancer 1984; 54: 1699-1704.
3. Vang R, Medeiros LJ, Fuller GN, Sarris AH, Deavers M. Non-Hodgkin’s lymphoma involving the gynecologic tract: a review of 88 cases. Adv Anat Pathol,2001:8, 200-17
4. Fox H, More JRS. Primary malignant lymphoma of the uterus. J Clin Pathol, 1965:18, 723-728.
5. Trenhaile TR, Killackey MA. Primary pelvic Non-Hodgkin’s Lymphoma. Obstetrics and Gynecology.2001 ;97:717-720
6. Young RH, Harris NL, Scully RE. Lymphoma like lesions of the lower female genital tract: a report of 16 cases. Int J Gynecol Pathol 1985, 4: 289-99. 7. Charlton I, Norris J, King FM. Malignant reticuloendothelial disease involving the ovary as a primary manfestation. Cancer. 1974; 34:397-407.
8. King J, Elkhalifa M, Michael C. Malignant lymphoma identified on cervical cytologic smear with Immunophenotypic analysis. Acta Cytologica 1996;40:1228
9. Rao IS. Role of immunohistochemistry in lymphoma. Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology. 2010; 31(4):145-147.
10. Stroh EL, Besa P, Cox D et al. Treatment of patients with lymphomas of the uterus or cervix with combination chemotherapy and radiation therapy. Cancer.1995; 75:2392-2399.
Published
2016-05-02
Issue
Section
Case Report
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