Non-Hodgkin Lymphoma of cervix: an unusual presentation

  • Mriganka Mouli Saha
  • Chhanda Das IPGME&R
  • Gourisankar Kamilya
  • Madhumita Mukhopadhyay
Keywords: Non-Hodgkin Lymphoma, CD 20, cervix, Diffiuse large B cell.


 Non-Hodgkin Lymphoma is diverse and often subdivided into diffuse large B-cell lymphoma, peripheral T-cell lymphoma, Burkitt’s lymphoma, mantle cell lymphoma and AIDS-related lymphoma. Primary lymphoma involving the uterine cervix is very rarely encountered. We are presenting here a case with post menopausal bleeding with provisional diagnosis of poorly differentiated cervical carcinoma. Radical hysterectomy (type II) with bilateral pelvic lymph node dissection was done . Specimen is sent for histopathological examination and it was reported as diffuse round cells proliferating  in an apparently unorganized fashion, with hyperchromatic nuclei and scanty cytoplasm and prominent nucleoli with possibility of poorly differentiated carcinoma or Non-Hodgkin lymphoma involving cervix. Immunohistochemistry study showed expression of CD 20 and negative expression of CD3 there by confirmed the diagnosis of diffuse large B cell type (DLBCL) Non-Hodgkin lymphoma of uterine cervix. The incidence of extranodal Non-Hodgkin Lymphoma is increasing. So, Clinicians and pathologists should be aware of this diagnosis in patients presenting with abnormal vaginal bleeding, and negative papanicolaou  test.

Author Biography

Chhanda Das, IPGME&R


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Case Report

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