Assessment of serum βhCG, lipid profile and uric acid levels in early second trimester as predictors of pregnancy induced hypertension.
Keywords:
PIH, βhCG, dyslipidemia, normotensive
Abstract
Background- Pregnancy induced hypertension is one of commonest complication affecting pregnant females with serious implications on both maternal and fetal health. Our aim is to assess the importance of measuring serum βhCG, lipid profile and uric acid levels in early second trimester of at-risk pregnant femalesMethods: A prospective study was conducted on 55 pregnant females visiting antenatal outpatient department of the Obstetrics and Gynaecology and department of pathology of MGH Hospital, RK Puram, New Delhi from January 2011 to December 2012. The study group included 25 at risk pregnant females and 30 females with normal pregnancyResults: In study group, the mean systolic and diastolic group was found to be higher than the healthy controls. The serum βhCG, lipid profile and uric acid levels were also found on higher side in the hypertensive group as compared to the normotensive pregnant females.Conclusion: Evaluation of maternal βhCG, lipid profile and uric acid can serve as reliable predictors of pregnancy induced hypertension. Early identification of at-risk women may help in taking timely preventive and curative management to prevent or halt pregnancy related complications.References
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2. Nayan S, Meena ML, Hooja N, Fatima A, Singh N, Aseri S. A Study of Comparison of Serum Lipid Profile of Women with Pregnancy Induced Hypertension and Normal Pregnancy. Sch. Acad. J. Biosci. 2014;2(11):834-836.
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4. Vidyabati RK, Hijam D, Singh NK, Singh WG. Serum βhCG and lipid profile in early second trimester as predictors of pregnancy induced hypertension. J ObstetGynecol India. 2014;60(1):44-50.
5. Kaur G, Jain V, Mehta S, Himani S. Prediction of PIH by Maternal Serum Beta HCG Levels in the Second Trimester (13–20 Weeks) of Pregnancy. J ObstetGynaecol India. 2012;62(1):32–34.
6. Hsu CD, Chan DW, Iriye B. Elevated serum human chorionic gonadotropin as evidence of secretory response in severe preeclampsia. Am J Obstet Gynecol. 1994;170:1135–1138.
7. Jayanta De, Mukhopadhyay AK, Saha PK. Study of serum lipid profile in pregnancy induced hypertension. Indian Journal of Clinical Biochemistry 2006;21(2):165-168.
8. Johnson RJ, Kanbay M, Kang DH, Lozada L, Feig D. Uric acid: A Clinically Useful Marker to Distinguish Preeclampsia from Gestational Hypertension. Hypertension 2011;58(4):548–549.
9. Adegoke OA, Iyare EE, Gbenebitse SO. Fasting plasma glucose and cholesterol levels in pregnant Nigerian women. Niger Postgrad Med J. 2003;10(1):32-6.
10. Sattar N, Greer IA, Louden J et al. Lipoprotein subfraction changes in normal pregnancy: threshold effect of plasma triglyceride on appearance of small dense low density lipoprotein. J ClinEndocrinolMetab 1997;82:2483-91.
11. Lorentzen B, Henriksen T. Plasma lipids and vascular dysfunction in preeclampsia. SeminReprodEndocrinol 1998;16:33-9.
12. Lorentzen B, Endressen MJ, Clausen T, et al. Fasting serum free fatty acids and triglycerides are increased before 20 weeks of gestation in women who later develop preeclampsia. Hypertens Pregnancy. 1994;13:103–9
13. Cekmen MB, Erbagci AB, Balat A, et al. Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension. ClinBiochem. 2003;36:575–578.
14. Vidyabati RK, Davina H, Singh NK, et al. Serum βhCG levels and lipid profile in early second trimester as predictors of pregnancy induced hypertension. J ObstetGynecol India. 2010;60(1):44–50.
15. Mallick MP, Ray S, Medhi R, Bisai S. Elevated serum βhCG and dyslipidemia in second trimester aspredictors of subsequent Pregnancy Induced Hypertension. Bangladesh Med Res Counc Bull 2014; 40: 97-101.
16. Johnson RJ, Kanbay M, Kang DH, Lozada GL, Feig D. Uric acid: A Clinically Useful Marker to Distinguish Preeclampsia from Gestational Hypertension. Hypertension. 2011;58(4):548–549.
17. Bainbridge SA, Roberts JM, von Versen-Hoynck F, Koch J, Edmunds L, Hubel CA. Uric acid attenuates trophoblast invasion and integration into endothelial cell monolayers. Am J Physiol Cell Physiol. 2009;297:440–450.
18. Tejal P, Astha D. Relationship of Serum Uric Acid Level to Maternal and Perinatal Outcome in Patientswith Hypertensive Disorders of Pregnancy. GMJ. 2014;69(2):45-46.
19. Bellomo G, Venanzi S, Saronio P, Verdura C. prognostic significance of serum uric acid in women with gestational hypertension. Hypertension. 2011;58(4):548-9.
2. Nayan S, Meena ML, Hooja N, Fatima A, Singh N, Aseri S. A Study of Comparison of Serum Lipid Profile of Women with Pregnancy Induced Hypertension and Normal Pregnancy. Sch. Acad. J. Biosci. 2014;2(11):834-836.
3. Cunningham FG, Leveno KJ, Bloom SL, et al. Pregnancy hypertension. In: Kenneth J, et al., editors. Williamsobsterics. 23. New York: McGraw-Hill; 2010. p. 706.
4. Vidyabati RK, Hijam D, Singh NK, Singh WG. Serum βhCG and lipid profile in early second trimester as predictors of pregnancy induced hypertension. J ObstetGynecol India. 2014;60(1):44-50.
5. Kaur G, Jain V, Mehta S, Himani S. Prediction of PIH by Maternal Serum Beta HCG Levels in the Second Trimester (13–20 Weeks) of Pregnancy. J ObstetGynaecol India. 2012;62(1):32–34.
6. Hsu CD, Chan DW, Iriye B. Elevated serum human chorionic gonadotropin as evidence of secretory response in severe preeclampsia. Am J Obstet Gynecol. 1994;170:1135–1138.
7. Jayanta De, Mukhopadhyay AK, Saha PK. Study of serum lipid profile in pregnancy induced hypertension. Indian Journal of Clinical Biochemistry 2006;21(2):165-168.
8. Johnson RJ, Kanbay M, Kang DH, Lozada L, Feig D. Uric acid: A Clinically Useful Marker to Distinguish Preeclampsia from Gestational Hypertension. Hypertension 2011;58(4):548–549.
9. Adegoke OA, Iyare EE, Gbenebitse SO. Fasting plasma glucose and cholesterol levels in pregnant Nigerian women. Niger Postgrad Med J. 2003;10(1):32-6.
10. Sattar N, Greer IA, Louden J et al. Lipoprotein subfraction changes in normal pregnancy: threshold effect of plasma triglyceride on appearance of small dense low density lipoprotein. J ClinEndocrinolMetab 1997;82:2483-91.
11. Lorentzen B, Henriksen T. Plasma lipids and vascular dysfunction in preeclampsia. SeminReprodEndocrinol 1998;16:33-9.
12. Lorentzen B, Endressen MJ, Clausen T, et al. Fasting serum free fatty acids and triglycerides are increased before 20 weeks of gestation in women who later develop preeclampsia. Hypertens Pregnancy. 1994;13:103–9
13. Cekmen MB, Erbagci AB, Balat A, et al. Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension. ClinBiochem. 2003;36:575–578.
14. Vidyabati RK, Davina H, Singh NK, et al. Serum βhCG levels and lipid profile in early second trimester as predictors of pregnancy induced hypertension. J ObstetGynecol India. 2010;60(1):44–50.
15. Mallick MP, Ray S, Medhi R, Bisai S. Elevated serum βhCG and dyslipidemia in second trimester aspredictors of subsequent Pregnancy Induced Hypertension. Bangladesh Med Res Counc Bull 2014; 40: 97-101.
16. Johnson RJ, Kanbay M, Kang DH, Lozada GL, Feig D. Uric acid: A Clinically Useful Marker to Distinguish Preeclampsia from Gestational Hypertension. Hypertension. 2011;58(4):548–549.
17. Bainbridge SA, Roberts JM, von Versen-Hoynck F, Koch J, Edmunds L, Hubel CA. Uric acid attenuates trophoblast invasion and integration into endothelial cell monolayers. Am J Physiol Cell Physiol. 2009;297:440–450.
18. Tejal P, Astha D. Relationship of Serum Uric Acid Level to Maternal and Perinatal Outcome in Patientswith Hypertensive Disorders of Pregnancy. GMJ. 2014;69(2):45-46.
19. Bellomo G, Venanzi S, Saronio P, Verdura C. prognostic significance of serum uric acid in women with gestational hypertension. Hypertension. 2011;58(4):548-9.
Published
2016-08-12
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