Platelet Volume Indices: Silver linings for vascular complications in diabetes mellitus

  • Mitakshara Sharma AIIMS
  • Sanjeev Narang
  • S K Nema
Keywords: Platelet Volume Indices, Mean Platelet Volume, Platelet Distribution Width, IFG, HBA1c, Diabetes

Abstract

Background: Morbidity and mortality in diabetes owing to micro and macro angiopathic complications is well known. Platelet indices are potentially useful surrogate markers for early diagnosis of diabetic complications attributed to platelet activation and recognized by increase in Platelet Volume Indices (PVI) including Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW). The aim is to determine and compare MPV and PDW in known cases of diabetics with and without diabetes related complications. To document changes in platelet indices with duration of diabetes and to assess utility of platelet indices in early identification of vascular complications especially in developing countries like India.Methods: A two year cross sectional study with total 330 individuals segregated into two groups:- (a)Diabetic subjects with diabetes related complications (b) Diabetic subjects without diabetes related complications. Samples for HbA1c and platelet indices were obtained and processed on SYSMEX-X-800i autoanalyser.Result: The study revealed significant positive correlation between PVI and duration of diabetes across the groups (MPV-HbA1c r = 0.951; PDW-HbA1c r = 0.875). MPV & PDW of subjects with and without diabetes related complications were (15.14 ± 1.04) fl & (17.51±0.39) fl and (18.96 ± 0.83) fl & (20.09 ± 0.98) fl respectively with a significant p value 0.00.Conclusion: The current study demonstrates raised platelet indices in association with rising glycaemic levels and diabetes related vascular complications. This is the first study of its kind in India which is comprehensive with an adequately powered study design. PVI should be researched and explored further as surrogate marker to develop a clinical tool for early recognition of diabetic vascular changes.

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Published
2016-10-11
Issue
Vol 3 No 4 (2016)
Section
Original Article

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