Rare presentation of medullary carcinoma of thyroid with predominant spindle cell pattern & abundant calcification
Keywords:
Medullary Carcinoma Thyroid, C Cells, Spindle Cell Morphology, Calcification
Abstract
Medullary carcinoma thyroid (MTC) is a malignant tumour showing C-cell differentiation. It accounts for 10% of all thyroid malignancies. Many histological variants have been described in literatures. Among them most predominant one is the classical variant, comprising almost one third of all. Predominantly spindle cell pattern is seen very rarely. MTCs are mostly seen in middle aged patient. It is rarely seen in second decade except familial type. Here we present a case of MTC with predominant spindle cell morphology & abundant calcification in a 19 years old female patient.References
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2. Baloch ZW, LiVolsi VA. Pathology of thyroid gland In: VA LiVolsi, SL Asa (eds), Endocrine Pathology, Churchill Livingstone, New York, 2002: 61-101.
3. Scopa CD. Histopathology of thyroid tumors. An overview. Hormones (Athens). 2004;3:100-10.
4. Desai SS, Sarkar S, Borges AM. A study of histopathological features of medullary carcinoma of the thyroid: cases from a single institute in India. Indian J Cancer. 2005;42:25-9.
5. Hazard JB, Hawk WA, Crile G Jr. Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity. J Clin Endocrinol Metab. 1959;19:152-61.
6. Papotti M, Volante M, Giuliano A, Fassina A, Fusco A, Bussolati G, Santoro M, Chiappetta G. RET/PTC activation in hyalinizing trabecular tumors of the thyroid. Am J Surg Pathol. 2000;24:1615-21.
7. Thompson LD. Medullary thyroid carcinoma. Ear Nose Throat J. 2010;89:301-2.
8. Moo-Young TA, Traugott AL, Moley JF. Sporadic and familial medullary thyroid arcinoma: State of the art. Surg Clin North Am 2009; 89: 1193-1204.
9. Takami H. Medullary thyroid carcinoma and multiple endocrine neoplasia type 2. Endocr Pathol 2003; 14: 123-31.
10. Etit D, Faquin WC, Gaz R, et al. Histopathologic and clinical features of medullary microcarcinoma and C-cell hyperplasia in prophylactic thyroidectomies for medullary carcinoma: A study of 42 cases. Arch Pathol Lab Med 2008; 132 (11): 1767-73.
11. Williams ED, Brown CL, Donaich I. Pathological and clinical findings in a series of 67 cases of medullary carcinoma of the thyroid. J Clin Pathol 1966; 19: 103-13.
Published
2016-07-29
Issue
Section
Case Report
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