Correlation Of Histopathological, Biochemical & Clinical Spectrum Of Chronic Hepatitis B: A New Look In To Old System

  • Aminder Singh Assistant Professor, Department of Pathology, Dayanand Medical College & Hospital, Tagore Nagar, Ludhiana
  • Bhavna Garg Professor, Department of Pathology, Dayanand Medical College & Hospital, Ludhiana
  • Neena Sood Professor, & Head, Department of Pathology, Dayanand Medical College & Hospital, Ludhiana
  • Ajit Sood Professor, & Head, Department of Gastroenterology, Dayanand Medical College & Hospital, Ludhiana
Keywords: Hepatitis B virus (HBV), HAI score, HBeAg, Anti HBe Antibody, Fibrosis

Abstract

Background: Hepatitis B virus infection is a global health problem. Histopathological examination is the mainstay in evaluating the disease progression and designing treatment protocols in these patients. The aim of this study is a correlation of histological features with clinical and biochemical parameters and what new could be proposed for the future by analyzing the limitations of scoring system used.Methods:  We evaluated 195 patients of hepatitis B virus infection over a period of 9 years & analysed their clinical & histological features and correlated them. Histological evaluation was done according to modified Ishak’s grading and Scheuer scoring system.Results: Patients were divided into age groups of < 40 & > 40 years. The majority of the patients were asymptomatic, male sex , younger age & had lower grade and stage. The mean values of total bilirubin and Prothrombin time of patient groups were within the normal ranges. A significant correlation was seen with stage III & IV and presence of HBe antigen & Anti HBe antibody cases [P-value < 0.05].Conclusions: We concluded that liver biopsy remains the only diagnostic test in evaluating liver pathology in hepatitis B infection. Plan the proper management needs certain modifications in the current existing scoring systems. 

Author Biography

Aminder Singh, Assistant Professor, Department of Pathology, Dayanand Medical College & Hospital, Tagore Nagar, Ludhiana
Assistant Professor, Department of PathologyAssistant Professor, Department of Pathology

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Published
2016-10-18
Issue
Vol 3 No 4 (2016)
Section
Original Article

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