Association of thyroid disorders with the hormones of anterior pituitary in female infertiltiy

  • Rakhee Yadav FMHS, SGT University, Gurgaon
  • Sanjiv Kumar Bansal FMHS, SGT University, Gurgaon
  • Busi Karunanand FMHS, SGT University, Gurgaon
  • Eram Hussain Pasha FMHS, SGT University, Gurgaon
  • Birendra Kumar Yadav FHMS, SGT University, Gurgaon
  • Smita Prasad Shastry FMHS, SGT University, Gugaon
Keywords: infertility, females, hypothyroidism, prolactin, LH, FSH

Abstract

Background: Fertility in femalesis centred on the functionalhypothalamo-pituitary-ovarian (HPO) axis. Thyroid dysfunctions are also known to interfere with the physiology of reproduction and pregnancy. This study was conducted with an objective to evaluate the relationship between thyroid and pituitary hormones in female infertility because abnormalities of HPO axis and thyroid dysfunction are one of the common and often treatable causes of infertility in females.Methods: Hundred female patients of infertility who visited the Department of Biochemistry, SGT Medical College, Hospital and Research Institute, Gurgaon for hormonal evaluation were recruited for the study. After excluding other causes of infertility including tubal factors, genetic or other anatomical factors; blood samples for TSH, LH, FSH and Prolactin were collected. Hundredage matched healthy fertile females were recruited as controls and their blood samples were collected for similar hormone assay. These parameters were estimated by the ELISA technique. Results were statistically analysed.Result: Out of the patients in our study group, 78% had primary infertility while secondary infertility was seen in 22% of the patients. Majority of the patients came out to be euthyroid (79%). There was a significant (p value<0.05) high serum level of Prolactin in patients of infertility as compared to controls. LH and FSH were found to be lower in infertile patients as compared to healthy controls. Moreover there was a significant positive correlation between the levels of TSH and Prolactin in infertile patients thus it might be imperative to say that hypothyroidism was strongly associated with hyperprolactinemia.Conclusion: For the normal physiology of reproduction, the functions of pituitary as well as thyroid should be normal. From our study we have elucidated that abnormalities of the thyroid gland and pituitary gland are interrelated. Thus their evaluation becomes necessary in order to elucidate the etiopathogenesis of female infertility which will further enhance the dimension towards designing effective treatment protocols.

Author Biographies

Rakhee Yadav, FMHS, SGT University, Gurgaon
Assistant Professor, Department of Biochemistry, FMHS, SGT University, Gurgaon (Haryana)
Sanjiv Kumar Bansal, FMHS, SGT University, Gurgaon
associate professor, deptt of Biochemistry, FMHS, SGT University, Gurgaon
Busi Karunanand, FMHS, SGT University, Gurgaon
Professor and Head, Deptt of Biochemistry, FMHS, SGT University, Gurgaon
Eram Hussain Pasha, FMHS, SGT University, Gurgaon
MD student, Deptt of Biochemistry, FMHS, SGT University, Gurgaon
Birendra Kumar Yadav, FHMS, SGT University, Gurgaon
PhD student, FMHS, SGT University, Gurgaon
Smita Prasad Shastry, FMHS, SGT University, Gugaon
PhD student, Deptt of Biochemistry, FMHS, SGT University, gurgaon

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Published
2016-10-26
Issue
Vol 3 No 4 (2016)
Section
Original Article

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