Evaluation of RAGE (Receptor for Advanced Glycation End-products) Expression in Gastric Carcinoma of Egyptian patients in Relation to Helicobacter pylori Infection

  • Tarek Aboushousha Professor and head of department of pathology, Theodore Bilharz Research Institute, Cairo- Egypt
  • Afkar Badawy
  • Mona Moussa
  • Zeinab Omran
  • Ahmed-Hazem Helmy
  • Magdy Youssef
Keywords: Gastric carcinoma, Helicobacter Pylori, RAGE


Background: Gastric cancer is one of the most common  malignancies and is the second most common cause of death from cancer worldwide. Gastric cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens or cellular damage, which can promote tumourigenesis.  Helicobacter pylori plays an important role in the pathogenesis of chronic gastritis and gastric adenocarcinoma. Receptor for Advanced Glycation End products (RAGE) is a pattern recognition receptor that binds multiple ligands derived from a damaged cell environment, and plays a critical role in promoting the intestinal tumorigenesis. The over-expression of RAGE has been associated with increased invasiveness and metastasis generation in different types of cancer, including gastric cancer. Therefore, the aim of this study was to evaluate the expression of RAGE protein in gastric carcinomas either in cases associated with Helicobacter pylori (Hp) infection or not, so as to predict its value as a target for therapy.Methods: 51 endoscopic and 19 surgical gastric biopsies including cases of gastric carcinoma, intestinal metaplasia and chronic gastritis were histopathologically  and immunohistochemically studied for RAGE expression  and were statistically discussed. Result: RAGE was not expressed in any case of gastritis or signet-ring gastric carcinomas. The RAGE cellular expression parameters were correlated significantly with the stages of gastric adenocarcinoma and lymph node metastasis and non-significantly with the grade of neoplasia. Our results showed no significant correlation between RAGE expression and Hp infection, either in chronic gastritis or malignant cases.Conclusion:  RAGE expression could be identified as a possible marker for target therapy in some types of gastric carcinoma, possibly to control its invasive and metastatic potential, however,  its relation to Hp infection was not quite evident in our current study.    


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