Combined stromal smooth muscle tumour of endometrium: report of two cases
Keywords:
Cellular Leiomyoma, Endometrial Stromal Nodule, Endometrial Stromal Sarcoma, Immunohistochemistry, Myometrium
Abstract
Endometrial stromal tumours account for < 10% of all mesenchymal uterine tumours. If smooth muscle differentiation comprises ≥30% of the tumour mass, the neoplasm is referred to as combined stromal smooth muscle tumour. We report here two cases of benign combined stromal smooth muscle tumour of endometrium, each discovered as an incidental finding in a hysterectomy specimen with a clinical diagnosis of fibroid uterus, where each of the two components- stromal and smooth muscle comprised more than 30% of the tumour. Although none of them showed features of malignancy. This report of two cases of benign combined stromal smooth muscle tumours of endometrium adds to the morphological spectrum of the endometrial mesenchymal tumours.References
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12. Oliva E, Young R H, Clement P B, et al. Cellular benign mesenchymal tumours of the uterus. A comparative morphologic and immunohistochemical analysis of 33 highly cellular leiomyomas and six endometrial stromal nodules, two frequently confused tumours. Am J Surg Pathol 1995; 19:757-68.
13. Oliva E, Young RH, Amin MB, et al. An immunohistochemical analysis of endometrial stromal and smooth muscle tumours of the uterus: a study of 54 cases emphasizing the crucial importance of using a panel because of overlap in immunoreactivity for individual antibodies. Am J Surg Pathol 2002; 26:403-12.
14. Loddenkemper C, Mechsner S, Foss H D, et al. Use of oxytocin receptor expression in distinguishing between uterine smooth muscle tumours and endometrial stromal sarcoma. Am J Surg Pathol 2003; 27:1458-62.
2. Oliva E, Clement PB, Young RH, et al. Mixed endometrial stromal and smooth muscle tumours of the uterus: a clinicopathologic study of 15 cases. Am J Surg Pathol1998:22:997–1005.
3. Schammel DP, Silver SA, Tavassoli FA. Combined endometrial stromal/smooth neoplasms of the uterus: a clinicopathological study of 38 cases [abstract]. Mod Pathol 1999:12:124A.
4. Tang C, Toker C, Ances IG. Stromomyoma of the uterus. Cancer 1979:43:308–16.
5. Chang KL, Crabtree GS, Lim-Tan SK, et al. Primary uterine endometrial stromal neoplasms. A clinicopathologic study of 117 cases. Am J Surg Pathol 1990:14:415–38.
6. Evans HL. Endometrial stromal sarcoma and poorly differentiated endometrial sarcoma. Cancer 1982:50:2170–82.
7. Fekete PS, Vellios F. The clinical and histologic spectrum of endometrial stromal neoplasms: a report of 41 cases. Int J Gynecol Pathol 1984:3:198–212.
8. Khalifa MA, Hansen CH, Moore JL, Jr, et al. Endometrial stromal sarcoma with smooth muscle differentiation: recurrence after 17 years: a follow-up report with discussion of the nomenclature. Int J Gynecol Pathol 1996:15:171–6.
9. Clement PB. The pathology of uterine smooth muscle tumours and mixed endometrial stromal-smooth muscle tumours: a selective review with emphasis on recent advances. Int J Gynecol Pathol 2000:19(1):39–55
10. Tavassoli FA, Norris HJ (1981) Mesenchymal tumours of the uterus. VII. A clinicopathological study of 60 endometrial stromal nodules. Histopathology 5:1–10
11. Baker P, Oliva E. Endometrial stromal tumours of the uterus; a practical approach using conventional morphology and ancillary techniques. J Clin Pathol. 2007; 60:235-243.
12. Oliva E, Young R H, Clement P B, et al. Cellular benign mesenchymal tumours of the uterus. A comparative morphologic and immunohistochemical analysis of 33 highly cellular leiomyomas and six endometrial stromal nodules, two frequently confused tumours. Am J Surg Pathol 1995; 19:757-68.
13. Oliva E, Young RH, Amin MB, et al. An immunohistochemical analysis of endometrial stromal and smooth muscle tumours of the uterus: a study of 54 cases emphasizing the crucial importance of using a panel because of overlap in immunoreactivity for individual antibodies. Am J Surg Pathol 2002; 26:403-12.
14. Loddenkemper C, Mechsner S, Foss H D, et al. Use of oxytocin receptor expression in distinguishing between uterine smooth muscle tumours and endometrial stromal sarcoma. Am J Surg Pathol 2003; 27:1458-62.
Published
2016-12-11
Section
Case Report
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