Persistent eosinophilia in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and TP53 deletion is a potential predictor of variant Richter’s transformation

  • Madhu M Ouseph Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
  • James N Butera Division of Hematology/Oncology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
  • Rogers C Griffith Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
  • Dariusz Stachurski Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
  • Diana Olguta Treaba Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Keywords: Eosinophilia, chronic lymphocytic leukemia, small lymphocytic lymphoma, classical Hodgkin lymphoma

Abstract

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) progression to diffuse large B-cell lymphoma (Richter’s syndrome) is noted in approximately 3 - 16% of the patients. However, transformation to classical Hodgkin lymphoma occurs in only 0.5% of the patients and has no clinically well-defined predictors. We report three patients with CLL/SLL and TP53 deletion in whom persistent eosinophilia preceded the Hodgkin lymphoma transformation

Author Biographies

Madhu M Ouseph, Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Department of Pathology and Laboratory MedicineResidents, PGY-3
James N Butera, Division of Hematology/Oncology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Associate Professor, Division of Hematology/Oncology
Rogers C Griffith, Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Associate Professor, Department of Pathology
Dariusz Stachurski, Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Assistant Professor, Department of Pathology
Diana Olguta Treaba, Department of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Department of Pathology and Laboratory MedicineDirector, HematopathologyAssociate Professor of Pathology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

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Published
2016-10-03
Issue
Vol 3 No 4 (2016)
Section
Case Report

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