Annals of Pathology and Laboratory Medicine 2019-05-24T18:25:24+00:00 Dr. Prashant Goyal Open Journal Systems <p><strong>Annals of Pathology and Laboratory Medicine (APALM)</strong> is an international, Double-blind peer-reviewed, indexed, open access, online and print journal&nbsp;for pathologists, microbiologist, biochemist and clinical laboratory scientists, and is published by <strong><a href="" target="_blank" rel="noopener"><strong>Pacific group of e-Journals</strong>' (<strong>PaGe</strong>)</a>, </strong>an&nbsp;<em>ISO 9001:2008</em> Certified&nbsp;academic publishing house.</p> <p>Set up in 2014, APALM is a specialized journal, which publishes original, peer-reviewed articles&nbsp;in the field of Pathology and Laboratory Medicine which, <em>inter alia</em>, includes Histopathology, Cytopathology, Hematology, Clinical Pathology, Forensic Pathology, Blood Banking, Clinical Bio-Chemistry, Medical Microbiology (Bacteriology, Virology, Mycology, Parasitology), etc.</p> <p><strong>DOI: 10.21276/APALM (<a title="Verify APALM DOI " href="" target="_blank" rel="noopener"></a>)<br></strong></p> <p>Index Copernicus (IC) Value (ICV 2016): 74.20</p> Cytomorphological Study of Palpable Soft Tissue Tumors by Fine Needle Aspiration Cytology 2019-05-24T18:25:24+00:00 Mamta Dwivedi Deepa Rani Anjani Kumar Tripathi Rohan Sirohi Atul Gupta Aradhana Singh <p><strong>Background:</strong> Soft tissue tumors are a highly heterogeneous group of tumors that are classified by the line of differentiation, according to the adult tissue they resemble. Objective of this study was to assess the utility of fine needle aspiration cytology (FNAC) in diagnosing soft tissue tumors and to do the histo-pathological correlation wherever possible.</p> <p><strong>Methods</strong>: Conventional May-Grunwald Giemsa (MGG) staining was done in all the 100 cases and cytodiagnosis was rendered. Histopathology was available in 41 cases. The cytological diagnosis was correlated with histology in these cases. The accuracy rate, sensitivity, specificity, the positive and negative predictive value were calculated. P value was found by applying Fisher’s exact test.</p> <p><strong>Results:</strong> The study was carried out on aspirates of 100 patients. Out of which 65 cases were benign, 30 were malignant while 5 cases were inadequate. Lipoma was the most common cytologically diagnosed benign lesion. Dermatofibrosarcoma protuberans (DFSP) and synovial sarcoma were found to be the most common malignant soft tissue tumors. Cyto-histological correlation could be achieved in 41 cases, with an accuracy of 92.7%.</p> <p><strong>Conclusion: </strong>FNAC is a well-tolerated and cost-effective procedure. It provides predictive diagnosis of benign or malignant soft tissue tumors and also specific tumor type, especially after correlation with clinical and radiological findings.</p> 2019-05-24T18:19:02+00:00 ##submission.copyrightStatement## Comparison of Histopathological Features of ‘Incidental’ and ‘Non-Incidental’ Papillary Thyroid Microcarcinomas 2019-05-24T18:24:07+00:00 Abhijit Kalita Annie Jojo Smitha NV <p><strong>Background: </strong>Papillary thyroid microcarcinoma (Pm) is defined as a papillary carcinoma with size ≤ 10mm. On clinical and histological grounds, there are two presentations-‘incidental’ and ‘non-incidental’. Histopathological parameters like intratumoral/peritumoral fibrosis, multifocality, infiltrative borders, subcapsular location, lymphovascular emboli and histological type have been introduced in the reporting of Pm, besides the size which is considered an important prognostic/risk factor.</p> <p><strong>Methods: </strong>The present study is a 5-year retrospective comparative study between the Pm which were incidentally detected, and those which had been previously diagnosed on fine needle aspiration/radiology or clinically suspicious of Pm.</p> <p><strong>Result: </strong>The number of cases in both incidental (111) and non-incidental (110) Pm have been found to be comparable in the present study, which is attributable to meticulous grossing and extensive sampling of all thyroidectomy specimen. Size and multifocality has been significantly different between incidental and non-incidental Pm (p-value &lt;0.05). The parameters like intratumoral/peritumoral fibrosis, infiltrative border and subcapsular location were significantly higher in larger sizes (&gt;5mm) of non-incidental Pm (p-value &lt;0.05). These parameters, however, were not found to be significant when analysed individually or with one another, between the two groups (p-value &gt;0.05). In the incidental Pm of size ≤ 5mm, a good proportion of cases show these parameters, implicating their importance for further follow-up.</p> <p><strong>Conclusion: </strong>Size and focality has been found to differ between incidental and non-incidental Pm. The histological parameters defined for Pm need to be followed up for a longer period to identify the prognostic significance, and their role in the different manifestation of incidental and non-incidental Pm.</p> 2019-05-24T18:24:07+00:00 ##submission.copyrightStatement##