Annals of Pathology and Laboratory Medicine
https://www.pacificejournals.com/journal/index.php/apalm
<p><strong>Annals of Pathology and Laboratory Medicine (APALM)</strong> is an international, Double-blind peer-reviewed, indexed, open access, online and print journal for pathologists, microbiologist, biochemist and clinical laboratory scientists, and is published by <strong><a href="https://www.pacificejournals.com" target="_blank" rel="noopener"><strong>Pacific group of e-Journals</strong>' (<strong>PaGe</strong>)</a>, </strong>an <em>ISO 9001:2008</em> Certified academic publishing house.</p> <p>Set up in 2014, APALM is a specialized journal, which publishes original, peer-reviewed articles in the field of Pathology and Laboratory Medicine which, <em>inter alia</em>, includes Histopathology, Cytopathology, Hematology, Clinical Pathology, Forensic Pathology, Blood Banking, Clinical Bio-Chemistry, Medical Microbiology (Bacteriology, Virology, Mycology, Parasitology), etc.</p> <p><strong>DOI: 10.21276/APALM (<a title="Verify APALM DOI " href="https://dx.doi.org/10.21276/apalm" target="_blank" rel="noopener">https://dx.doi.org/10.21276/apalm</a>)<br></strong></p> <p>Indexed in: </p> <p><strong>EMBASE</strong></p>Pacific Group of e-Journals (PaGe)en-USAnnals of Pathology and Laboratory Medicine2394-6466<p>Authors who publish with this journal agree to the following terms:</p> <ol> <li class="show">Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a <a href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</a> that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li> <li class="show">Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li> <li class="show">Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).</li> </ol> <p> </p>Frequency of Immunofluorescence Antinuclear Antibody Patterns: In A Local Population from North India
https://www.pacificejournals.com/journal/index.php/apalm/article/view/3291
<p><strong>Background</strong></p> <p>Autoimmune disorders in India have seen rise in recent times. The first-line test in diagnostic workup of autoimmune disorders is ANA indirect Immunofluorescence (IIF). A positive Antinuclear antibodies (ANA) result in conjunction with clinical findings aids in predicting the diagnosis. ANA test is not widely available in India, probably due to the cost and requirement of technical expertise. In view of rising incidence of autoimmune disorders in India and due to scarcity of data, this study aimed at determining prevalence of ANA positivity, study ANA patterns and their frequency and estimate disease burden in patients among local population of Northern India.</p> <p><strong>Methods</strong></p> <p>The study was performed on 2000 suspected autoimmune disorder patients during a period of 01 year (January 2023 till January 2024). Assessment of ANA patterns and titres were carried out by ANA-IIF technique.</p> <p><strong>Result</strong></p> <p>Of the 2000 participants, 30.8% were found to be ANA-positive. Nuclear speckled pattern was observed to be the most common, among others. Among mixed ANA patterns, mix of speckled and homogenous patterns were common. Females showed predominance over males in all age groups in ratio of 3:1.</p> <p><strong>Conclusion</strong>:</p> <p>The study is a preliminary, retrospective study providing overview of ANA positivity and autoimmunity status in Northern India, where despite the heavy disease burden, data is still scarce. Further studies in Indian population are essential to determine relationship of ANA with various etiologic and biochemical factors and association between ANA patterns and specific antibodies in serum for diagnosis of specific autoimmune diseases.</p>Rani DeepakCharu AgrawalSunita KapoorRitesh Kanotra
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2024-02-282024-02-28113A101610.21276/apalm.3291A Systemic Review of T Regulatory Cells and Their Role In Hodgkin and Non-Hodgkin Lymphoma
https://www.pacificejournals.com/journal/index.php/apalm/article/view/3258
<p>Regulatory T cells (Tregs) know for monitoring and regulating the immune response in healthy individuals. In hematological malignancies, Tregs cells exert an immunosuppressive effect thus playing an important role in tumor progression and spread. It is a systemic review focusing on evolution and prognostic role of Tregs in hematological malignancies and the results are very conflicting. Different tissues (peripheral blood, Lymphnode tissue and bone marrow) were used for studies with applications of different methods like Flow cytometry on whole blood / isolated peripheral blood mononuclear cells with different gating techniques, Immunohistochemistry using different panel of monoclonal antibodies, which partially explained the confrontation of results. It is of particular importance to mention above finding to solidify the requirement of use of standardized approaches in study of Tregs in hematological malignancies and in cancer.</p>Nishant TaurRashmi KushwahMili JainAkansha SinghRahul Mittal
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2024-02-282024-02-28113R11110.21276/apalm.3258Micro-Erythrocyte Sedimentation Rate in Adults: A Nuanced Perspective on Utility in Emergency and Resource-constrained Clinical Settings
https://www.pacificejournals.com/journal/index.php/apalm/article/view/3296
Seetu Palo
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2024-02-282024-02-28113L1210.21276/apalm.3296