Annals of Pathology and Laboratory Medicine

Pattern Analysis Of Purely Dermal Cutaneous Mesenchymal Tumours Presenting As Superficial Palpable Growth

Swati Patki — 2018-04-21

Background: Cutaneous mesenchymal tumours are relatively rare except for a small number of lesions that are very common. Benign cuteneous soft tissue tumors outnumber malignant tumors by a wide margin.Malignant cutaneous soft tissue tumors, on the other hand, ultimately come to medical attention. Soft tissue sarcomas, compared with carcinomas and other neoplasms, are relatively rare and constitute fewer than 1% of all cancers .A systematic approach can help achieve a definitive diagnosis or limit a differential diagnosis and prevents over-treatment or under-treatment.This study will focus on primary cutaneous (particularly dermal) soft tissue tumours that can be part of syndrome e.g. neurofibromas associated with von Recklinghausen’s disease or benign tumors that simulate malignancies and are often misdiagnosed as such e.g. fibrous histiocytoma and low-grade malignant cutaneous soft tissue tumours that although rare are often associated with high morbidity and mortality.

Material and Methods: The present cross sectional analytical study was conducted in department of Pathology of a tertiary care hospital over a period of five years. All the incision biopsy and resection specimens received in the department of surgical pathology suggestive of cutaneous soft tissue tumours (purely dermal) as per clinical and morphological details.

Result Analysis:The data was analyzed using rates, ratios and percentages. Association between incidence of cutaneous soft tissue tumours & various demographic parameters like age, sex, were calculated.

Conclusion:Pathologists play an important role in reaching to accurate morphological diagnosis with the aid of IHC to prevent any uncertainty due to indistinct clinical features.

DOI:10.21276/APALM.1388

Correlation of Haemoglobin level and Urine Albumin in relation to Glycated Haemoglobin in Type 2 Diabetes

Sonti Sulochana — 2018-04-21

Aim and Objective : The Aim and objective of the present study is to correlate haemoglobin , urine albumin with glycated haemoglobin also called as HbA1c testing.

Settings and Design : This study was conducted on 100 Diabetic patients without hypertension ,coronary artery disease & pregnancy.

Methods and Material : Blood samples of diabetic subjects were collected and analyzed for Glycated haemoglobin using Glucose oxidase method and haemoglobin using automated analyzer sysmex XN 1000, Urine albumin measured with URODIP 10A Reagent strips . The data was analyzed by descriptive analysis.

Result And Conclusion : Result shows that Haemoglobin were significantly reduced in diabetic patients with high glycated haemoglobin and presence of urine albumin which is highly increased in diabetic patients with high glycated haemoglobin .

DOI:10.21276/APALM.1626

Haemolytic anaemia in Kavaratti island, Lakshadweep: A hospital based study.

Poonam Khambra — 2018-04-21

Background: Anaemia is a major public health problem in developing countries like India. Kavaratti island, Lakshadweep is a remote island located in Arabian sea. There is extreme paucity of data on the type of anaemia here. Objective of this study is to take an in depth look at the various etiologies of anaemia at Kavaratti island, Lakshadweep.

Methods: A total of 4526 patients were studied. Data from the anaemic individuals was collected and analyzed. The study group was subsequently divided into smaller subgroups on the basis of age and sex for analysis. The aetiology of anaemia in these cases was further investigated.

Result: The prevalence of anaemia in adult males was 21.5% and in females 37%. In pregnant females anaemia was still more common (47.5%). Among children 24.6% were anaemic with female children showing higher percentage (27.4%) than males (22.9%). Anaemia was quite common in the elderly and even higher in elderly females (43%). However, the most significant finding was the high prevalence of haemolytic anaemias especially sickle cell anaemia.

Conclusion: Anaemia is not a major public health problem in Kavaratti island, Lakshadweep. However, there is high prevalence of haemolytic anaemias especially sickle cell anaemia. Nutritional anaemia is quite rare. This fact may have major implications for health policy makers.

DOI:10.21276/APALM.1673

Histopathological Analysis of Synovial Lesions

Archana Panage — 2018-04-21

Introduction: Histopathological evaluation of synovial tissue is not routinely done for diagnosis in patients of arthritis, however it is of diagnostic value in patients, particularly if the joint involvement is monoarticular. A final diagnosis may be arrived at after considering the clinical and serological findings.

Materials and Methods: We have analyzed a series of 46 cases which included 24 diagnostic biopsies and 22 cases of synovium sampled during joint replacement surgeries. Tissue was processed routinely, stained with Haematoxylin and Eosin and special stains when necessary.Histopathological findings were correlated with clinical, radiological, serological findings, TB culture and TB- PCR results wherever available.

Results: We observed that knee joint was most commonly affected (73.91). Chronic non-specific inflammation was the most common histological finding seen in 15 cases (32.60%), 5 cases of which was further diagnosed as tuberculous synovitis based on, clinical and laboratory findings. This was followed by 11 cases (23.91%) of chronic degenerative osteoarthritis, nine (19.56%) cases of rheumatoid arthritis, and 5 cases (10.86%) of granulomatous inflammation. Other specific diagnosis included synovial lipomatosis, non-hemophilic hemosiderotic synovitis, synovial chondromatosis, gouty arthritis and pseudogout. In this study, we have discussed the importance of histopathological evaluation and clinical correlation in diagnosing synovial lesions.

Conclusion: Histopathological findings in synovial lesions has its own limitations and may also be modified by treatment or chronicity of disease. However when correlated with clinical, serological and other investigations, it is of diagnostic importance in synovial lesions.

DOI:10.21276/APALM.1651