Study of platelet count and mean platelet volume according to the use or non-use of therapeutic hypothermia

  • Yuko Sakurai Division of Neonatology, Saitama Children’s Medical Center, 1696 Itai, Kumagaya, Saitama 360-0105, Japan
  • Mitsuhiro Haga Division of Neonatology, Saitama Children’s Medical Center, 1696 Itai, Kumagaya, Saitama 360-0105, Japan
  • Hisako Saeki Division of Neonatology, Saitama Children’s Medical Center, 1696 Itai, Kumagaya, Saitama 360-0105, Japan
  • Chika Kanno Division of Neonatology, Saitama Children’s Medical Center, 1696 Itai, Kumagaya, Saitama 360-0105, Japan
  • Masayuki Kanno Division of Neonatology, Saitama Children’s Medical Center, 1696 Itai, Kumagaya, Saitama 360-0105, Japan
  • Masami Kanno Division of Neonatology, Saitama Children’s Medical Center, 1696 Itai, Kumagaya, Saitama 360-0105, Japan
  • Ken Kawabata Division of Neonatology, Saitama Children’s Medical Center, 1696 Itai, Kumagaya, Saitama 360-0105, Japan
  • Masaki Shimizu Division of Neonatology, Saitama Children’s Medical Center, 1696 Itai, Kumagaya, Saitama 360-0105, Japan
Keywords: Mean Platelet Volume, Platelet Count, Therapeutic Hypothermia, Neonatal Hypoxic Ischemic Encephalopathy

Abstract

Background: We examined changes in mean platelet volume (MPV) and platelet count according to the use or nonuse of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy (HIE).Methods: We divided the newborn infants who were diagnosed as having HIE into the therapeutic hypothermia group (TH group, 24 infants) and non-therapeutic hypothermia group (non-TH group, 31 infants) and examined perinatal information and platelet count and MPV on admission, postnatal day 5, and postnatal day 7.Result: In the TH group, an increase in MPV was found from admission to postnatal day 5 (p=0 .03), whereas no change was found from postnatal day 5 to day 7 (p=0 .36). In the non-TH group, MPV increased from admission to postnatal day 5 (p<0 .01) and did not change from postnatal day 5 to day 7 (p=0.71). Within the two groups, a high level of MPV was found only on postnatal day 7 in the TH group (p<0.01). A negative correlation was found between platelet count and MPV on admission and on postnatal days 5 and 7 in the TH group (admission: p=0.02, R=0.46; postnatal day 5: p=0.03, R=0.43; postnatal day 7: p=0.03, R=0.42), but no correlation was found at any time point in the non-TH group (admission: p=0.93, R=0.11; postnatal day 5: p=0.07, R=0.28; postnatal day 7: p=0.58, R=0.13).Conclusion: Even if therapeutic hypothermia was implemented early after birth, we presumed that the bone marrow maintained the platelet count by increasing platelet production as the platelet count decreased.DOI: 10.21276/AWCH.1867

Author Biography

Yuko Sakurai, Division of Neonatology, Saitama Children’s Medical Center, 1696 Itai, Kumagaya, Saitama 360-0105, Japan
Division of Nonatology

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Published
2018-02-06
Section
Original Articles