Study of platelet count and mean platelet volume according to the use or non-use of therapeutic hypothermia
Keywords:
Mean Platelet Volume, Platelet Count, Therapeutic Hypothermia, Neonatal Hypoxic Ischemic Encephalopathy
Abstract
Background: We examined changes in mean platelet volume (MPV) and platelet count according to the use or nonuse of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy (HIE).Methods: We divided the newborn infants who were diagnosed as having HIE into the therapeutic hypothermia group (TH group, 24 infants) and non-therapeutic hypothermia group (non-TH group, 31 infants) and examined perinatal information and platelet count and MPV on admission, postnatal day 5, and postnatal day 7.Result: In the TH group, an increase in MPV was found from admission to postnatal day 5 (p=0 .03), whereas no change was found from postnatal day 5 to day 7 (p=0 .36). In the non-TH group, MPV increased from admission to postnatal day 5 (p<0 .01) and did not change from postnatal day 5 to day 7 (p=0.71). Within the two groups, a high level of MPV was found only on postnatal day 7 in the TH group (p<0.01). A negative correlation was found between platelet count and MPV on admission and on postnatal days 5 and 7 in the TH group (admission: p=0.02, R=0.46; postnatal day 5: p=0.03, R=0.43; postnatal day 7: p=0.03, R=0.42), but no correlation was found at any time point in the non-TH group (admission: p=0.93, R=0.11; postnatal day 5: p=0.07, R=0.28; postnatal day 7: p=0.58, R=0.13).Conclusion: Even if therapeutic hypothermia was implemented early after birth, we presumed that the bone marrow maintained the platelet count by increasing platelet production as the platelet count decreased.DOI: 10.21276/AWCH.1867References
1. Staub A, Schiebold D, Wendel HP, Hamilton C, Wagner T, Schmid E,et al. Using reagent-supported thromboelastometry (ROTEM) to monitor haemostatic changes in congenital heart surgery employing deep hypothermic circulatory arrest. Eur J Cardiothorac Surg 2008;34:641-648.
2. Faraday N, Rosenfeld BA. In vitro hypothermia enhances platelet GPIIb-IIIa activation and P-selectin expression. Anesthesiology 1998;88:1579-1585.
3. Kamiya H, Hagl C, Kropivnitskaya I, Böthig D, Kallenbach K, Khaladj N, et al. The safety of moderate hypothermic lower body circulatory arrest with selective cerebral perfusion: A propensity score analysis. J Thorac Cardiovasc Surg 2007;133:501-509.
4. Augoustides JG, Floyd TF, McGarvey ML, Ochroch EA, Pochettino A, Fulford S, et al. Major clinical outcomes in adults undergoing thoracic aortic surgery requiring deep hypothermic circulatory arrest: Quantification of organ-based perioperative outcome and detection of opportunities for perioperative intervention. J Cardiothorac Vasc Anesth 2005;19:446-452.
5. Di Eusanio M1, Wesselink RM, Morshuis WJ, Dossche KM, Schepens MA. Deep hypothermic circulatory arrest and antegrade selective cerebral perfusion during ascending aorta-hemiarch replacement: A retrospective comparative study. J Thorac Cardiovasc Surg 2003;125:849-854.
6. Dossche KM, Morshuis WJ, Schepens MA, Waanders FG. Bilateral antegrade selective cerebral perfusion during surgery on the proximal thoracic aorta. Eur J Cardiothorac Surg 2000;17: 462-467.
7. Takayama W, Kobayashi Y, Ochiai R. Deep hypothermic circulatory arrest and selective cerebral perfusion induced reversible thrombocytopenia during aortic arch repair. Journal of Medical Society of Toho University 2012;59:2-8.
8. Chakravorty S, Murray N, Roberts I. Neonatal thrombocytopenia. Early Hum Dev 2005;81:35-41.
9. Roberts IA, Murray NA. Thrombocytopenia in the newborn. Curr Opin Pediatr 2003;15:17-23.
10. Sola MC, Del Vecchio A, Rimsza LM. Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. Clin Perinatol 2000;27:655-679.
11. von Lindern JS, van den Bruele T, Lopriore E, Walther FJ. Thrombocytopenia in neonates and the risk of intraventricular hemorrhage: a retrospective cohort study: BMC Pediatr 2011;11:16.
12. Kaushansky K. The molecular mechamisms that control thrombopoiesis: J Clin Invest. 2005;115(12):3339-47
13. Nurden AT, Viallard JF, Nurden P. New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura: Lancet 2009; 373(9674): 1562-9
14. Numbenjapon T, Mahapo N, Pornvipavee R, Sriswasdi C, Mongkonsritragoon W, Leelasiri A, et al: A prospective evaluation of normal mean platelet volume in discriminating hyperdestructive thrombocytopenia from hypoproductive thrombocytopenia. Int J Lab Hematol 2008;30:408-414.
15. Arad ID, Alpan G, Sznajderman SD, Eldor A. The mean platelet volume (MPV) in the neonatal period. Am J Perinatol 1986;3:1-3.
16. Cekmez F, Tanju IA, Canpolat FE, Aydinoz S, Aydemir G, Karademir F, et al: Mean platelet volume in very preterm infants: a predictor of mordibities? Eur Rev Med Pharmacol Sci 2013;17:134-137.
17. Boutaybi N, Razenberg F, Smits-Wintjens VE, van Zwet EW, Rijken M, Steggerda SJ, et al. Neonatal thrombocytopenia after perinatal asphyxia treated with hypothermia: A retrospective case control study. Int J Pediatr 2014;2014:760654.
18. Pina-Cabral JM, Amaral I, Pinto MM, Guerra e Paz LH. Hepatic and splenic platelet sequestration during deep hypothermia in the dog. Pathophysiol Haemost Thromb 1973;2:235-244.
19. Pina-Cabral JM, Ribeiro-da-Silva A, Almeida-Dias A. Platelet sequestration during hypothermia in dogs treated with sulphinpyrazone and ticlopidine--reversibility accelerated after intra-abdominal rewarming. Thromb Haemost 1985;54:838-841.
2. Faraday N, Rosenfeld BA. In vitro hypothermia enhances platelet GPIIb-IIIa activation and P-selectin expression. Anesthesiology 1998;88:1579-1585.
3. Kamiya H, Hagl C, Kropivnitskaya I, Böthig D, Kallenbach K, Khaladj N, et al. The safety of moderate hypothermic lower body circulatory arrest with selective cerebral perfusion: A propensity score analysis. J Thorac Cardiovasc Surg 2007;133:501-509.
4. Augoustides JG, Floyd TF, McGarvey ML, Ochroch EA, Pochettino A, Fulford S, et al. Major clinical outcomes in adults undergoing thoracic aortic surgery requiring deep hypothermic circulatory arrest: Quantification of organ-based perioperative outcome and detection of opportunities for perioperative intervention. J Cardiothorac Vasc Anesth 2005;19:446-452.
5. Di Eusanio M1, Wesselink RM, Morshuis WJ, Dossche KM, Schepens MA. Deep hypothermic circulatory arrest and antegrade selective cerebral perfusion during ascending aorta-hemiarch replacement: A retrospective comparative study. J Thorac Cardiovasc Surg 2003;125:849-854.
6. Dossche KM, Morshuis WJ, Schepens MA, Waanders FG. Bilateral antegrade selective cerebral perfusion during surgery on the proximal thoracic aorta. Eur J Cardiothorac Surg 2000;17: 462-467.
7. Takayama W, Kobayashi Y, Ochiai R. Deep hypothermic circulatory arrest and selective cerebral perfusion induced reversible thrombocytopenia during aortic arch repair. Journal of Medical Society of Toho University 2012;59:2-8.
8. Chakravorty S, Murray N, Roberts I. Neonatal thrombocytopenia. Early Hum Dev 2005;81:35-41.
9. Roberts IA, Murray NA. Thrombocytopenia in the newborn. Curr Opin Pediatr 2003;15:17-23.
10. Sola MC, Del Vecchio A, Rimsza LM. Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. Clin Perinatol 2000;27:655-679.
11. von Lindern JS, van den Bruele T, Lopriore E, Walther FJ. Thrombocytopenia in neonates and the risk of intraventricular hemorrhage: a retrospective cohort study: BMC Pediatr 2011;11:16.
12. Kaushansky K. The molecular mechamisms that control thrombopoiesis: J Clin Invest. 2005;115(12):3339-47
13. Nurden AT, Viallard JF, Nurden P. New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura: Lancet 2009; 373(9674): 1562-9
14. Numbenjapon T, Mahapo N, Pornvipavee R, Sriswasdi C, Mongkonsritragoon W, Leelasiri A, et al: A prospective evaluation of normal mean platelet volume in discriminating hyperdestructive thrombocytopenia from hypoproductive thrombocytopenia. Int J Lab Hematol 2008;30:408-414.
15. Arad ID, Alpan G, Sznajderman SD, Eldor A. The mean platelet volume (MPV) in the neonatal period. Am J Perinatol 1986;3:1-3.
16. Cekmez F, Tanju IA, Canpolat FE, Aydinoz S, Aydemir G, Karademir F, et al: Mean platelet volume in very preterm infants: a predictor of mordibities? Eur Rev Med Pharmacol Sci 2013;17:134-137.
17. Boutaybi N, Razenberg F, Smits-Wintjens VE, van Zwet EW, Rijken M, Steggerda SJ, et al. Neonatal thrombocytopenia after perinatal asphyxia treated with hypothermia: A retrospective case control study. Int J Pediatr 2014;2014:760654.
18. Pina-Cabral JM, Amaral I, Pinto MM, Guerra e Paz LH. Hepatic and splenic platelet sequestration during deep hypothermia in the dog. Pathophysiol Haemost Thromb 1973;2:235-244.
19. Pina-Cabral JM, Ribeiro-da-Silva A, Almeida-Dias A. Platelet sequestration during hypothermia in dogs treated with sulphinpyrazone and ticlopidine--reversibility accelerated after intra-abdominal rewarming. Thromb Haemost 1985;54:838-841.
Published
2018-02-06
Issue
Section
Original Articles
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).