Adenomyoepithelioma arising in axillary breast tissue: a diagnostic rarity: case report with literature review
Keywords:
Adenomyoepithelioma, Myoepithelial cell, Axillary breast tissue
Abstract
Adenomyoepithelioma is an uncommon, benign tumor of biphasic nature which arises from myoepithelial and epithelial cells. It has been recognized mainly in breast tissue, along with skin adnexa, lungs and salivary glands. The typical histologic appearance consists of acinar structures composed of an inner layer of epithelial cells with eosinophilic cytoplasm and a prominent peripheral layer of myoepithelial cells with clear cytoplasm. Prognosis of patients with AME is usually good, but it has a potential for local recurrence and rarely, malignant transformation with distant metastases to lung, brain, and liver. We present the rare case of a 42 year old female with left sided axillary lump that was diagnosed as adenomyoepithelioma arising from accessory breast tissue in the axilla. This of interest not only because of the rarity of the lesion, but also due to the peculiarity of its origin from accessory mammary gland tissue of axillary location.References
1. Yoon JY, Chitale D. Adenomyoepithelioma of the Breast: A Brief Diagnostic Review. Archives of Path and Lab Med. May 2013; 137 (5): 725-729
2. Rosen PP. Adenomyoepithelioma of the breast. Hum Pathol. 1987; 18(12):1232–1237.
3. Kiaer H, Nielsen B, Paulsen S, Sorensen I, Dyreborg U, Blichert-Toft M: Adenomyoepithelial adenosis and low-grade malignant adenomyoepithelioma of the breast. Virchows Arch A Pathol Anat Histopathol; 1984; 405: 55-67.
4. Choi JS, Bae JY, Jung WH. Adenomyoepithelioma of the breast. Yonsei Med J 1996;37:284-289.
5. Tavassoli FA. Myoepithelial lesions of the breast: myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol. 1991;15(6):554–568.
6. Loose JH, Patchefsky AS, Hollander IJ, et al. Adenomyoepithelioma of the breast: a spectrum of biologic behavior. Am J Surg Pathol. 1992; 16(9):868–876.
7. McLaren BK, Smith J, Schuyler PA, Dupont WD, Page DL. Adenomyoepithelioma: clinical, histologic, and immunohistologic evaluation of a series of related lesions. Am J Surg Pathol. 2005;29(10):1294–1299.
8. Hayes MM. Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation. J Clin Pathol. 2011;64(6):477–484.
9. Hoda SA, Rosen PP. Observations on the pathologic diagnosis of selected unusual lesions in needle core biopsies of breast. Breast J. 2004;10(6):522–527.
2. Rosen PP. Adenomyoepithelioma of the breast. Hum Pathol. 1987; 18(12):1232–1237.
3. Kiaer H, Nielsen B, Paulsen S, Sorensen I, Dyreborg U, Blichert-Toft M: Adenomyoepithelial adenosis and low-grade malignant adenomyoepithelioma of the breast. Virchows Arch A Pathol Anat Histopathol; 1984; 405: 55-67.
4. Choi JS, Bae JY, Jung WH. Adenomyoepithelioma of the breast. Yonsei Med J 1996;37:284-289.
5. Tavassoli FA. Myoepithelial lesions of the breast: myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol. 1991;15(6):554–568.
6. Loose JH, Patchefsky AS, Hollander IJ, et al. Adenomyoepithelioma of the breast: a spectrum of biologic behavior. Am J Surg Pathol. 1992; 16(9):868–876.
7. McLaren BK, Smith J, Schuyler PA, Dupont WD, Page DL. Adenomyoepithelioma: clinical, histologic, and immunohistologic evaluation of a series of related lesions. Am J Surg Pathol. 2005;29(10):1294–1299.
8. Hayes MM. Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation. J Clin Pathol. 2011;64(6):477–484.
9. Hoda SA, Rosen PP. Observations on the pathologic diagnosis of selected unusual lesions in needle core biopsies of breast. Breast J. 2004;10(6):522–527.
Published
2016-06-01
Issue
Section
Case Reports
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