Role of Uric Acid in Coronary Artery Disease

  • Priyanka Rana SGPGI Lucknow
  • V Ramesh SGPGI Lucknow
Keywords: Uric acid, Coronary Artery Disease


Background:    It has been seen that free radicals are involved in the pathogenesis of atherosclerosis.  Serum uric acid act as a prooxidant particularly at higher concentration and considered to be associated with various cardiovascular risk factors. As it acts as a prooxidant at higher concentration, our aim is to see whether the increased serum uric acid levels can be used for monitoring CAD. Methods: 300 patients of CAD were included. In addition to a detailed history and physical examination, anthropometric parameters like body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting serum lipid profile, uric acid and glucose levels were measured. Prevalence of metabolic syndrome using ATP III criteria was studied.    Result: In our study hypertriglyceridemia, BMI and prevalence of metabolic syndrome showed a steady and a significant increase with increasing levels of serum uric acid.    Conclusion: In our study there is significant positive relationship of increased serum uric acid with two cardiovascular risk factors i.e. Triglyceride and prevalence of metabolic syndrome.


Stringer MD, Goros PG, Freeman A, Kakkar VV. Lipid peroxides and atherosclerosis. Br MedJ, 1989; 298: 281-4.

Poulter N, Sever P, Thorn S, et al. Cardiovascular diseases: Risk factors and interventions. Oxford: Radcliffe Medical Press, 1993; 351pp.

Hennekens CH, Gaziano JM. Antioxidants and heart diseases: epidemiology and clinical evidence. ClinCardiol, 1993; 16(Suppl. 1): 1710-13.

Becker BF. Towards the physiological function of uric acid. Free RadicBiol Med,1993; 14: 615-31.

Strazzullo P, Puig JG. Uric acid and oxidative stress: relative impact on cardiovascular risk? NutrMetabCardiovasc Dis, 2007; 17: 409-14.

Hayden MR, Tyagi SC. Uric acid: a new look at an old risk marker for cardiovascular disease, metabolic syndrome and type 2 diabetes mellitus: the urate redox shuttle.

Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. N Eng J Med, 2008; 359: 1811-21.

Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid induced C-reactive protein expression: Implication on cell proliferation and nitric oxide production of human vascular cells. J Am SocNephrol, 2005; 16: 3553-62.

Nakanishi N, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K.Serum uric acid and risk of development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers. Eur J Epidemiol, 2003; 18: 523-30.

Fachini F, Chen YD, Hollenbeck CB, Reaven GM. Relationship betweenresistance to insulin mediated glucose uptake, urinary uric acid clearance and plasma uric acid concentration. JAMA, 1991; 266: 3008-3011.

NakagaweT, Hu H, Zharikor S et al. A causal role for uric acid in fructose –induced metabolic syndrome. Am J Renal Physiol, 2006; 290: F625-F631.

Hjortnaes J, Algra A, Olijhoek J, Huisman M, Jacobs J, Graaf Y, Visseren F. Serum Uric acid levels and risk of vascular diseases in patients with metabolic syndrome. Journal of Rheumatology, 2007; 349: 1882-87.

Car S, Trkuja V. Higher Sreum uric acid on admission is associated with higher short term mortality and poorer long term survival after myocardial infarction: Retrospective Prognostic Study. Clinical Science, 2009; 50: 559-566.

Kojima S, Sakamoto J, Ishihara M, Kimura K, Miyazaki S, Yamagishi M et al. Prognostic usefulness of Serum uric acid after acute myocardial infarction (the Japanese Acute Coronary Syndrome Study). Am J Cardiol, 2005; 96: 489-95.

Bickel C, Rupprecht HJ, Blankenberg S, Rippin G, Hafner G, Daunhauer A, Hofman KP, Meyer J. Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary aretery disease. American Journal of Cardiology, 2002; 89: 12-17.

Brodov Y, Behar S, Goldenberg I, Boyko V, Chouraqui P. Usefulness of combining uric acid and C- reactive protein for risk stratification of patients with coronary artery disease. Am J Cardiol, 2009;104:194-198.

Original Article