Role of Uric Acid in Coronary Artery Disease
AbstractBackground: It has been seen that free radicals are involved in the pathogenesis of atherosclerosis. Serum uric acid act as a prooxidant particularly at higher concentration and considered to be associated with various cardiovascular risk factors. As it acts as a prooxidant at higher concentration, our aim is to see whether the increased serum uric acid levels can be used for monitoring CAD. Methods: 300 patients of CAD were included. In addition to a detailed history and physical examination, anthropometric parameters like body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting serum lipid profile, uric acid and glucose levels were measured. Prevalence of metabolic syndrome using ATP III criteria was studied. Result: In our study hypertriglyceridemia, BMI and prevalence of metabolic syndrome showed a steady and a significant increase with increasing levels of serum uric acid. Conclusion: In our study there is significant positive relationship of increased serum uric acid with two cardiovascular risk factors i.e. Triglyceride and prevalence of metabolic syndrome.
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