Clinicopathological profile of Chronic Lymphocytic Leukemia – Study from a tertiary care center in Southern India.
AbstractBackground: Chronic lymphocytic leukemia (CLL) is the most common leukemia in the West, the incidence of which in comparison is low in India. In this descriptive study, we have tried to analyse the clinicopathological spectrum of newly diagnosed cases of CLL. Materials and Methods: In this descriptive cross-sectional study, 75 newly diagnosed cases of CLL between January 2010 to December 2017 were analysed for the clinical and hematological parameters along with immunohistochemical profile. Results: The median age was 59 years with a male preponderance. Generalized lymphadenopathy was observed in 53 (70.7%) patients and hepatosplenomegaly in 22 (29.3%) patients. There were 7 (9.3%) cases with low risk, 28 (37.3%) cases with intermediate risk and 40 (53.3%) cases with high risk according to modified Rai staging. The most common patterns of bone marrow infiltration was diffuse pattern. High risk Rai staging was associated with diffuse pattern of bone marrow infiltration. Atypical immunophenotype was observed in 9 (12%) cases. Conclusions: CLL presents at an earlier age group in this cohort of patients studied in Southern India along with increased incidence among patients younger than 55 years of age. The most common pattern of bone marrow infiltration was diffuse pattern which correlates with high-risk presentation. Keywords: Chronic Lymphocytic Leukemia, clinicopathological profile, bone marrow
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