Evaluation of Metastatic Cutaneous Lesions on Fine Needle Aspiration Cytology: A Five Year Study
Keywords:
FNAC, Metastases, Cutaneous
Abstract
Background: Cutaneous and subcutaneous metastatic deposits are rare and can be seen in 0.8-5% cases.This study was done to evaluate the role of Fine Needle Aspiration Cytology(FNAC) in the diagnosis of cutaneous and subcutaneous nodules in patients with known malignancy or as a primary manifestation of an unknown malignancy.Materials and methods: It was a 5 year retrospective study and the record of patients subjected to FNAC during this period was reviewed.Results:Out of total number of 13572 patients 58(0.42%) were diagnosed as cutaneous /subcutaneous metastatic deposits .In 51 cases ,the primary was known and in 7 cases it was an initial manifestation of an unknown primary.There were 39 males and 19 females with age range of 27-82 years .Conclusion:Commonest site of metastases was chest wall and most common primary was lung. Adenocarcinoma was the commonest diagnosis on morphology. This study emphasizes the efficacy of FNAC on the accurate diagnosis of subcutaneous nodules especially in patients with known malignancy .It also offers clue to the underlying malignancy in occult primary.DOI: 10.21276/AABS.2017.1368References
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5. Sharma, S., Kotru, M., Yadav, A., Chugh, M., Chawla, A. and Makhija, M. (2009), Role of fine-needle aspiration cytology in evaluation of cutaneous metastases. Diagn. Cytopathol., 37: 876–880.
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8. Bansal R, Patel T, Sarin J, Parikh B, Ohri A, Trivedi P. Cutaneous and subcutaneous metastasis from internal malignancy. An analysis of cases diagnosed by fine needle aspiration. Diagn Cytopathol 2011;39(12) 882-7
9. Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol 1995;33:161-82
10. Didolkar MS, Fanous N, Elias EG, Moore RH. Metastatic Carcinomas from Occult Primary Tumors: A Study of 254 Patients. Annals of Surgery 1977;186(5):625-630.
11. Osteen RT, Kopf G, Wilson RE. In pursuit of the unknown primary. Am J Surg. 1978 Apr;135(4):494–497.
12. Rahman G A, Abdulkadir A Y, Olatoke S A, Yusuf I F, Braimoh K T. Unusual cutaneous metastatic follicular thyroid carcinoma. J Surg Tech Case Report 2010;2:35-8
13. Agarwal S, Rao S, Arya A, Gupta K, Arora R, Dhawan I. Follicular thyroid carcinoma with metastasis to skin diagnosed by fine needle aspiration cytology. Indian J Pathol Microbiol 2008;51:430-1
14. Caron Ph, Moreau-Cabarrot A, Gorguet B & Bazex J. Cutaneous metastasis from follicular carcinoma of the thyroid gland.Thyroid 1993;3:235–237.
15. Corcoran S, Hogan AM, Nemeth T, et al. Isolated cutaneous metastasis of uterine leiomyosarcoma: case report and review of literature. Diagnostic Pathology 2012;7:85.
16. Rao UM, Hanan AH, Karakousis CP. et al. Distant skin and soft tissue metastases from sarcomas. J Surg Oncol. 1998;69:94–98.
17. Fluehler C, Quaranta L, di Meo N, Ulessi B, Trevisan G. Cutaneous Metastasis of Neuroendocrine Carcinoma. Indian Journal of Dermatology 2013;58(3):247.
18. Reich A, Wróbel G, Kazanowska B et al: Skin involvement in highly malignant non-Hodgkin lymphomas of childhood and adolescence. Acta Dermatovenerol Alp Panonica Adriat 2006; 15(4):158-68.
19. Rodrigues LK, Leong SP, Ljung BM, et al.Fine needle aspiration in the diagnosis of metastatic melanoma. J Am Acad Dermatol. 2000;42:735–740.
2. Geramizadeh B, Marzban S, Karamifar N et al. Diagnosis of Subcutaneous Metastatic Deposits by Fine Needle Aspiration. J Cytol Histol 2012; 3:151.
3. Nava G, Greer K, Patterson J, Lin KY. Metastatic cutaneous breast carcinoma: A case report and review of the literature. The Canadian Journal of Plastic Surgery 2009;17(1):25-27.
4. Erdemır AT, Atılganoglu U, Onsun N, Somay A. cutaneous metastases from gastric adenocarcinoma. indian journal of dermatology 2011;56(2):236-237.
5. Sharma, S., Kotru, M., Yadav, A., Chugh, M., Chawla, A. and Makhija, M. (2009), Role of fine-needle aspiration cytology in evaluation of cutaneous metastases. Diagn. Cytopathol., 37: 876–880.
6. Fyrmpas G, Barbetakis N, Efstathiou A, Konstantinidis I, Tsilikas C. Cutaneous metastasis to the face from colon adenocarcinoma. Case report. Int Semin Surg Oncol 2006;3:2
7. Molina Garrido MJ, Mora Rufete A, Guillen Ponce C, Macia Escalante S, Carrato Mena A. Skin metastases as first manifestation of lung cancer. Clin Transl Oncol. 2006;8:616–617.
8. Bansal R, Patel T, Sarin J, Parikh B, Ohri A, Trivedi P. Cutaneous and subcutaneous metastasis from internal malignancy. An analysis of cases diagnosed by fine needle aspiration. Diagn Cytopathol 2011;39(12) 882-7
9. Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol 1995;33:161-82
10. Didolkar MS, Fanous N, Elias EG, Moore RH. Metastatic Carcinomas from Occult Primary Tumors: A Study of 254 Patients. Annals of Surgery 1977;186(5):625-630.
11. Osteen RT, Kopf G, Wilson RE. In pursuit of the unknown primary. Am J Surg. 1978 Apr;135(4):494–497.
12. Rahman G A, Abdulkadir A Y, Olatoke S A, Yusuf I F, Braimoh K T. Unusual cutaneous metastatic follicular thyroid carcinoma. J Surg Tech Case Report 2010;2:35-8
13. Agarwal S, Rao S, Arya A, Gupta K, Arora R, Dhawan I. Follicular thyroid carcinoma with metastasis to skin diagnosed by fine needle aspiration cytology. Indian J Pathol Microbiol 2008;51:430-1
14. Caron Ph, Moreau-Cabarrot A, Gorguet B & Bazex J. Cutaneous metastasis from follicular carcinoma of the thyroid gland.Thyroid 1993;3:235–237.
15. Corcoran S, Hogan AM, Nemeth T, et al. Isolated cutaneous metastasis of uterine leiomyosarcoma: case report and review of literature. Diagnostic Pathology 2012;7:85.
16. Rao UM, Hanan AH, Karakousis CP. et al. Distant skin and soft tissue metastases from sarcomas. J Surg Oncol. 1998;69:94–98.
17. Fluehler C, Quaranta L, di Meo N, Ulessi B, Trevisan G. Cutaneous Metastasis of Neuroendocrine Carcinoma. Indian Journal of Dermatology 2013;58(3):247.
18. Reich A, Wróbel G, Kazanowska B et al: Skin involvement in highly malignant non-Hodgkin lymphomas of childhood and adolescence. Acta Dermatovenerol Alp Panonica Adriat 2006; 15(4):158-68.
19. Rodrigues LK, Leong SP, Ljung BM, et al.Fine needle aspiration in the diagnosis of metastatic melanoma. J Am Acad Dermatol. 2000;42:735–740.
Published
2017-02-27
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