Syphilis in Blood Donors in Tertiary Care Teaching Hospital
Keywords:
Treponema pallidum, Seroprevalence, Transfusion transmitted diseases, Voluntary donors, Replacement donors
Abstract
Introduction -Transmission of infectious diseases through donated blood is of concern to blood safety as transfusion forms an integral part of medical and surgical therapy. Blood transfusion carries the risk of transfusion-transmissible infections, including HIV, hepatitis, syphilis, malaria and infrequently toxoplasmosis.Aims & Objectives -To find out the seroprevalence of Syphilis in blood donors, to find the incidence of spectrum of Transfusion transmitted dieasess in blood bank donation & to find the age distribution of the cases studied.Material & methods -The present study was undertaken in the Department of Pathology MGM Medical College Indore. This is a retrospective study that was conducted, during the period 2008 –2015. The screening for Syphilis was done by rapid chromatographic assay for detection of antibodies to T.pallidum Results - Out of total 137689 blood donations, majority of donors are voluntary donors 83.02 % as compared to replacement donors 17.05 %. Seroprevalence of Anti TP is 0.26 %. Seroprevalence of Anti TP is higher in the age group 26-35 year . Among Voluntary & replacement/relative donors . Overall seropositivity of TTI’s (HIV,HBV,HCV,Syphilis & Malaria) is higher in replacement donors 3.71 % as compared to voluntary donors 1.75 %.Conclusion -voluntary blood donation should be encouraged for prevention of transfusion-transmissible diseases. The time and cost involved in screening donated blood can be reduced by an effective donor education and selection program that promotes self-exclusion by donors at risk of transfusion-transmissible infections. DOI: 10.21276/AABS.1687References
1. Tang, J. and Kaslow, R. A. (2003). "The impact of host genetics on HIV infection and disease progression in the era of highly active antiretroviral therapy". AIDS 17 (Suppl 4): S51–S60.
2. World Health Organization. Global prevalence & incidence of selected curable sexually transmitted infections: overview & estimates (2001). Available at : http://www.who.int/hiv/pub/sti/en/who_hiv_aids_2014.05.pdf.
3. Kaur.G, Kaur.P : Syphilis testing in blood donors: an update. Blood Transfus 2015;13:197-204
4. Ananthnarayan.R & Panicker C.K in Ananthnarayan. & Panicker’s Textbook of Microbiology 8th Edition Chapter 42 pg 371. University Press.
5. De Schryver A, Meheus A. Syphilis & blood transfusion: a global perspective. Transfusion 1990;30:844-7
6. Gardella C, Marin AA, Kahn RH et al. Persons with early syphilis identified through blood or plasma donation screening in United states. J Infect Dis 2002; 185:545-9
7. Orton S. Syphilis & blood donors: what we know, what we do not know, & what we need to know. Transfus Med Rev 2001;15:282-91.
8. Wendel S. Current concepts on transmission of bacteria & parasites by blood components. Vox Sang 1994;67(Suppl3):161-74
9. Kaur G, Basu S, Kaur R et al. Patterns of infections blood donors in a tertiary care center: A retrospective study. Natl Med J India 2010:23;147-9
10. Bhalti FA, Ullah Z, Salamat N, et al . Anti-Hepatitis B core antigen testing, viral markers & occult Hepatitis b infection in Pakistani blood donors: implication for transfusion practice. Transfusion 2007; 47:74-9
11. Matee MI, Magesa PM, Lyamuya EF. Seroprevalence of Human immunodeficiency virus, Hepatitis B & C virus and syphilis infections among blood donors at Muhimbili National hospital in Dar es Salam, Tanzania. BMC Public health 2006;6:21
12. Kulkarni N. Analysis of the seroprevalence of HIV, HBsAg, HCV and syphilitic infections detected in the pretranfusion blood: A short report. International Journal of Blood Transfusion and Immunohematology 2012;2:1-3.
13. Dimple Arora, Bharti Arora, AnshulKhetarpal“Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana" Year 2010 Vol: 53(2)Page308-309
14. Manisha Jain, Anita Chakravarti, VikasVerma, PreenaBhalla”Seroprevalence of hepatitis viruses in patients infected with the human immunodeficiency virus” Year : 2009 Vol: 52( 1)Page : 17-19
15. Sultan S, Murad S Irfan m et al . Trends of venereal infections among healthy blood donors at Karachi. Arch Iran Med 2016;19(3):192-196
16. Elyamany G et al. Prevalence of syphilis among blood & stem cell donors in Saudi Arabia: an institutional experience.2016;Vol 8 Issue 8: 2747-2751
17. Zulfikar A, Umaru N, Shreesha K. Seroprevalence of Transfusion transmitted Infections among blood donors in Mangalore. Medica Innov. Dec 2012, Vol 1, issue 2; 24-27
18. Belay Tessema et al “Seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital, Northwest Ethiopia: declining trends over a period of five years” BMC Infectious Diseases201010:111
2. World Health Organization. Global prevalence & incidence of selected curable sexually transmitted infections: overview & estimates (2001). Available at : http://www.who.int/hiv/pub/sti/en/who_hiv_aids_2014.05.pdf.
3. Kaur.G, Kaur.P : Syphilis testing in blood donors: an update. Blood Transfus 2015;13:197-204
4. Ananthnarayan.R & Panicker C.K in Ananthnarayan. & Panicker’s Textbook of Microbiology 8th Edition Chapter 42 pg 371. University Press.
5. De Schryver A, Meheus A. Syphilis & blood transfusion: a global perspective. Transfusion 1990;30:844-7
6. Gardella C, Marin AA, Kahn RH et al. Persons with early syphilis identified through blood or plasma donation screening in United states. J Infect Dis 2002; 185:545-9
7. Orton S. Syphilis & blood donors: what we know, what we do not know, & what we need to know. Transfus Med Rev 2001;15:282-91.
8. Wendel S. Current concepts on transmission of bacteria & parasites by blood components. Vox Sang 1994;67(Suppl3):161-74
9. Kaur G, Basu S, Kaur R et al. Patterns of infections blood donors in a tertiary care center: A retrospective study. Natl Med J India 2010:23;147-9
10. Bhalti FA, Ullah Z, Salamat N, et al . Anti-Hepatitis B core antigen testing, viral markers & occult Hepatitis b infection in Pakistani blood donors: implication for transfusion practice. Transfusion 2007; 47:74-9
11. Matee MI, Magesa PM, Lyamuya EF. Seroprevalence of Human immunodeficiency virus, Hepatitis B & C virus and syphilis infections among blood donors at Muhimbili National hospital in Dar es Salam, Tanzania. BMC Public health 2006;6:21
12. Kulkarni N. Analysis of the seroprevalence of HIV, HBsAg, HCV and syphilitic infections detected in the pretranfusion blood: A short report. International Journal of Blood Transfusion and Immunohematology 2012;2:1-3.
13. Dimple Arora, Bharti Arora, AnshulKhetarpal“Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana" Year 2010 Vol: 53(2)Page308-309
14. Manisha Jain, Anita Chakravarti, VikasVerma, PreenaBhalla”Seroprevalence of hepatitis viruses in patients infected with the human immunodeficiency virus” Year : 2009 Vol: 52( 1)Page : 17-19
15. Sultan S, Murad S Irfan m et al . Trends of venereal infections among healthy blood donors at Karachi. Arch Iran Med 2016;19(3):192-196
16. Elyamany G et al. Prevalence of syphilis among blood & stem cell donors in Saudi Arabia: an institutional experience.2016;Vol 8 Issue 8: 2747-2751
17. Zulfikar A, Umaru N, Shreesha K. Seroprevalence of Transfusion transmitted Infections among blood donors in Mangalore. Medica Innov. Dec 2012, Vol 1, issue 2; 24-27
18. Belay Tessema et al “Seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital, Northwest Ethiopia: declining trends over a period of five years” BMC Infectious Diseases201010:111
Published
2017-10-14
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