Effect of Monosodium Glutamate on Mice Ovaries and Possible Protective Role of Vitamin C
Keywords:
Monosodium Glutamate, Mice ovary, Oxidative Stress, Vitamin C.
Abstract
Background: Monosodium Glutamate a commonly used food additive that produce oxidative stress causing pathogenesis in several tissues and play a role in anovulatory infertility.Methods: This study was carried out on 24 adult female Swiss albino mice, they were divided into three equal groups each contained 8 mice: Group I (control): they were fed on standard diet. Group II: adult mice treated with MSG 4 mg / g body weight. Group III: adult mice treated with MSG 4 mg/g body weight and vitamin C 100mg/kg B.WT. administered orally for 14 days.Results: In group II, MSG reduced number of for primary, secondary, and Graafian follicles but it increased atretic follicles also it caused vacuolation of follicular cells and congestion of medullary blood vessels. However Vitamin C in group III ameliorated the mentioned histological changes caused by MSG in group II..Conclusion: MSG causes oxidative stress affecting ovarian tissue particularly the growing follicles, maturation of follicles, and decreased ovulation. Vitamin C is an effective antioxidant agent reducing the oxidative stress effect of MSG.References
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9. Das RS and Ghosh SK . Long term effects in ovaries of the adult mice following exposure to Monosodium glutamate during neonatal life – a histological study.Nepal Med Coll J 2011; 13(2): 77-83.
10. Olney JW, Sharpe LG, Feigin RD. Glutamate induced brain damage in infant primates. J Neuropathol Exp Neurol 1972; 31: 464-87.
11. Miskowiak B, Partyka M. Long term effect of neonatal Monosdium Glutamate treatment on the reproductive system of the female rat. Folia Morphol (Warsz) 1999; 58: 105-13.
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13. Pizzi WJ, Barnhart JE. Monosodium glutamate administration of newborn reduces reproductive ability in female and male mice. Sci 1977; 196: 452-4.
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17. Hashem H. E.,Din Safwat D.M.,Algaidi S. Effect of MSG on cerebellar cortex of male albino rats and the protective role of vitamin C.(Histological & Immunohistochemical study). Journal of Molecular Histology 2012; 4392:179-86.
18. Eweka,A.O., Igibgbi, P.S.&Ucheya R.E. Histochemical studies of the effectsof Monosodium Glutamate on the liver of Adults Wistar Rats. Annal of Medical &Health Sciences Research 2011; 1(1): 21-9.
19. Gill S., Barker M., Pulido O. Neuroexcitatory targets in the female reproductive system of the nonhuman prinates (Macca fascicularis). Toxicol.Pathol 2008; 36: 478-484.
20. Eweka ,A.O.,Eweka A. AND Om’iniabohs,F.A.E. Histological studies of the effects of Monosodium Glutamate of the Fallopian Tubes of Adult female Wistar Rats. North American Journal of Medical Sciences 2010; 2(3): 146-9.
21. El-Deeb R, Zakaria I, Abd El-Khalik I, Abd Ei-Aziz S. The influence of short and long term treatment with Slidnafil Citrate on the testes and liver of albino rats. Egypt J Zoo 2000; 35:163-187.
22. Cheville NF. Ultrastructural Pthology: The comparative cellular basis of disease.2nd ed.USA. Wiley-Blackwell. A John Wiley of Sons Inc; 2009.
23. Henic T, Wheatley DN. Cytoplasmic vacuolation, adaptation, and cell death: a aview on new perspective and features. Biol. Cell 1999; 91(7):485-498.
24. AL-Mosabih M.A. Effect of Monosodium Glutamate and Acrylamide on liver tissue of adult Wistar rats. Life Sci.J. 2013; 10:35.
25. Singh K. and Ahluwalia P. Studies on the effect of monosodium glutamate (MSG) administration on some antioxidant enzymes in the artresial tissue of adult male mice. J Nutr SCi Vitaminol (Tokyo).
2003; 49: 145- 148.
26. Veronika Husarova and Daniela Ostatnikova. Monosodium Glutamate Toxic Effects andTheir Implication for Human Intake: A Review.JMED Research. 2013; 10: 608765.
27. Ismail N.H. Assesment of DNA damage in testes form young Wistar Male Rats treated with MonoSodium Glutamate.Life science J. 2012; 9:930-934.
2. Moore KL. Congenital malformations due to environmental. Developing humans. 2nd ed. Philadelphia: W.B. Saunders Co. Ltd; 2003. 173–183.
3. Ahmed Abozaid Ali, Ghada Hassan El-Seify, Hala Mohammed El Haroun, Mona Abd El Mawla Mohammed Soliman. Effect of monosodium glutamate on the ovaries of adult female albino rats and the possible protective role of green tea. Menoufia Med J 2014; 27:793–800.
4. Eweka O. Histological studies of the effects of monosodium glutamate on the kidney of adult Wistar rats. Internet J Health 2007; 6:2.
5. Samuels S. The toxicity/safety of MSG: a study in suppression of information. Account Res 1999; 6(4):259–310.
6. Aisha D. Alalwani. Monosodium glutamate induced testicular lesions in rats (histological study).Middle East Fertility Society Journal 2014; 19, 274–280.
7. Udensi M. Igwebuike, Izuchukwu S. Ochiohu, Blessing C. Ihedinihu, Joseph E. Ikokide, Idika K. Idika. The effects of oral administration of monosodium glutamate (msg) on the testicular morphology and cauda epididymal sperm reserves of young and adult male rats. VETERIN. ARSKI ARHIV; 2011 81 (4), 525-534.
8. Eweka AO, Om’iniabohs FAE. Histological studies of the effects of monosodium glutamate on the ovaries of adult wistar rats. Ann Med Health Sci Res 2011; 1:37–44.
9. Das RS and Ghosh SK . Long term effects in ovaries of the adult mice following exposure to Monosodium glutamate during neonatal life – a histological study.Nepal Med Coll J 2011; 13(2): 77-83.
10. Olney JW, Sharpe LG, Feigin RD. Glutamate induced brain damage in infant primates. J Neuropathol Exp Neurol 1972; 31: 464-87.
11. Miskowiak B, Partyka M. Long term effect of neonatal Monosdium Glutamate treatment on the reproductive system of the female rat. Folia Morphol (Warsz) 1999; 58: 105-13.
12. Rodriguez-Sierra JF, Sridaran R, Blake CA. Monosodium Glutamate disruption of behavioral and endocrine function in the female rat. Neuroendocrinol 1980; 31: 228-35.
13. Pizzi WJ, Barnhart JE. Monosodium glutamate administration of newborn reduces reproductive ability in female and male mice. Sci 1977; 196: 452-4.
14. Ashamu EA, Salawu EO, Oyewo OO. Efficacy of vitamin C and ethanolic extract of Sesamum indicum in promoting fertility in male wistar rats. J Hum Reprod Sci; 2013; 3(1):11-14.
15. Sies H.and Stabl W.Vitamin E and C, and Carotene and other Carotenoids as Antioxidants .The American Journal of Chemical Nutrition 1995; 62: 13155-13215.
16. Walker, R. and Lupien, J. R. The Safety Evaluation of Monosodium Glutamate, Journal of Nutrition 2000; 130(4S Suppl): 1049S- 1052S.
17. Hashem H. E.,Din Safwat D.M.,Algaidi S. Effect of MSG on cerebellar cortex of male albino rats and the protective role of vitamin C.(Histological & Immunohistochemical study). Journal of Molecular Histology 2012; 4392:179-86.
18. Eweka,A.O., Igibgbi, P.S.&Ucheya R.E. Histochemical studies of the effectsof Monosodium Glutamate on the liver of Adults Wistar Rats. Annal of Medical &Health Sciences Research 2011; 1(1): 21-9.
19. Gill S., Barker M., Pulido O. Neuroexcitatory targets in the female reproductive system of the nonhuman prinates (Macca fascicularis). Toxicol.Pathol 2008; 36: 478-484.
20. Eweka ,A.O.,Eweka A. AND Om’iniabohs,F.A.E. Histological studies of the effects of Monosodium Glutamate of the Fallopian Tubes of Adult female Wistar Rats. North American Journal of Medical Sciences 2010; 2(3): 146-9.
21. El-Deeb R, Zakaria I, Abd El-Khalik I, Abd Ei-Aziz S. The influence of short and long term treatment with Slidnafil Citrate on the testes and liver of albino rats. Egypt J Zoo 2000; 35:163-187.
22. Cheville NF. Ultrastructural Pthology: The comparative cellular basis of disease.2nd ed.USA. Wiley-Blackwell. A John Wiley of Sons Inc; 2009.
23. Henic T, Wheatley DN. Cytoplasmic vacuolation, adaptation, and cell death: a aview on new perspective and features. Biol. Cell 1999; 91(7):485-498.
24. AL-Mosabih M.A. Effect of Monosodium Glutamate and Acrylamide on liver tissue of adult Wistar rats. Life Sci.J. 2013; 10:35.
25. Singh K. and Ahluwalia P. Studies on the effect of monosodium glutamate (MSG) administration on some antioxidant enzymes in the artresial tissue of adult male mice. J Nutr SCi Vitaminol (Tokyo).
2003; 49: 145- 148.
26. Veronika Husarova and Daniela Ostatnikova. Monosodium Glutamate Toxic Effects andTheir Implication for Human Intake: A Review.JMED Research. 2013; 10: 608765.
27. Ismail N.H. Assesment of DNA damage in testes form young Wistar Male Rats treated with MonoSodium Glutamate.Life science J. 2012; 9:930-934.
Published
2015-11-09
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