Effect of Monosodium Glutamate on Mice Ovaries and Possible Protective Role of Vitamin C

  • Snoor Jalal Mustafa School of Medicine/ University of Sulaimani
Keywords: Monosodium Glutamate, Mice ovary, Oxidative Stress, Vitamin C.


Background: Monosodium Glutamate a commonly used food additive that produce oxidative stress causing pathogenesis in several tissues and play a role in anovulatory infertility.Methods: This study was carried out on 24 adult female Swiss albino mice, they  were divided into three equal groups each contained 8 mice: Group I (control): they were fed on standard diet. Group II: adult mice treated with MSG 4 mg / g body weight. Group III: adult mice treated with MSG 4 mg/g body weight and vitamin C 100mg/kg B.WT. administered orally for 14 days.Results: In group II, MSG reduced number of for primary, secondary, and Graafian follicles but it  increased atretic follicles also it caused vacuolation of follicular cells and congestion of medullary blood vessels. However Vitamin C in group III ameliorated the mentioned histological changes caused by MSG  in group II..Conclusion: MSG causes oxidative stress affecting ovarian tissue particularly the growing follicles, maturation of follicles, and decreased ovulation. Vitamin C is an effective antioxidant agent reducing the oxidative stress effect of MSG.  


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