Ki-67 Expression in Urinary Bladder Carcinomas and Its Prognostic Role

  • Krishna Kanth G.V.R.N
  • Muralikrishna Bogi
  • Keerthana J
  • Nishanth N
  • Satyanarayana V
Keywords: Ki-67, Transitional Cell Carcinoma, Bladder Carcinoma, Immunohistochemisrty, Cell Proliferation Markers


Background: Transitional cell carcinoma is the commonest histological type of bladder malignancies.There is a need for good prognostic markers that help to decide which group of patients need to be subjected to chemotherapy.The present  study  determines the expression of the cell proliferative marker Ki-67 and correlates it with pathologic features and disease prognosis in patients with transitional cell carcinoma (TCC) of the urinary bladder.Methods: Immunohistochemical staining for Ki-67 was done on tissue blocks ofcystectomy specimens from  patients  with bladder TCC.Results: Ki-67 expression was increased in 56% of cystectomy specimens. Ki-67 overexpression was associated with advanced pathologic stage, higher grade, and metastases to lymph nodes (P = 0.001, 0.040., and 0.036, respectively).Conclusion:  Ki-67 overexpression is associated with features of aggressive bladder TCC and adds independent prognostic information to standard pathologic features for prediction of clinical outcome after radical cystectomy.


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