Prevalence of molar pregnancy (a three year retrospective study) in a tertiary care ho
Keywords:
Hydatidiform Mole, Trophoblastic Hyperplasia, Cisterns
Abstract
Hydatidiform mole is an abnormal gestation characterized by trophoblastic hyperplasia and overgrowth of placental villi. H. mole is classified as complete (CHM) and partial (PHM). The diagnosis is based on histopathology and genetic origin. In our set up, we used only histopathological diagnostic criteria. The incidence of molar pregnancy varies in different parts of the world. The malignant potential of the disease is higher in South East Asia as compared to western countries. Objective of the present study was to determine the frequency, clinical presentation and morphological features of H. mole and compare them with those of other studies.This is a 3 year retrospective descriptive case series conducted in the Department of Pathology, SKIMS Medical College, Bemina from 31st December 2011 to 31st December 2014. The case records of all the molar pregnancies during the study period were analysed regarding patient’s history, clinical presentation and morphological features. A total of 50 cases were examined during the study period which included 38 cases of complete mole and 11 cases of partial mole. One case was labeled as complete mole with atypical trophoblastic proliferation. Frequency of CHM was higher as compared to partial mole. The disease was common in extremes of ages. A number of histopathological diagnostic criterias are used to distinguish CHM from PHM.We concluded that there is no single criterion to differentiate CHM from PHM.References
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11. JaffarRozina, KalsoomRahat and QuershiAsmaa. Histopathological review of partial and complete hydatiform moles in a tertiary care hospital , Lahore. 27 ,76-80; 2011.
12. Nizam K, Haider G, Memon N, Haider A. Gestational trophoblastic disease. Experience at NawabshahHospital . J Ayub Med Coll .21; 2009.
13. Koirala A, Khatiwada P, Giri A , Kandel P, Rigmi M, Upreti D. The demographiesof molar pregnancy in BPKIHS, Kathmandu Univ Med J ,36(4); 298-300;2011.
14. Mayun AA, Rafindadi AH , Shehu MS. Pathomorphology of molar gestation in Zaria. 51(1) ; 1-4, 2010.
2. Khaskheli M, Khushk I.A, Baloch S and Shah H.,”Gestational trophoblastic disease:experience at a tertiary care hospital of Sindh”,Journal of the college of physicians and surgeons Pakistan,17(2);81-83,2007.
3. Fisher RA , Hodges MD , Rees HC , Sebire NJ , Seckl MJ , Newlands ES , Genest DR , Castrillon DH. The maternally described gene p57kip2 (CDN1KC) is abnormally expressed in both androgenetic and biparental complete hydatidiform moles. Human molecular genetic ,11; 3267-72, 2002.
4. Merchant SH , Amin MB , Vishwanatha DS, Malhotra RK , MoehLenkamp , Joste NE . p57kip2 Immunohistochemistry in early molar pregnancies . Emphasis on its complementary role in differential diagnosis of hydropicabortuses. Human Pathol , 36 ;180-86,2005.
5. Hoffner L , Dunn J , Esposito N , Macpherson T , Surti U. p57kip2 Immunostaining and molecular cytogenetics. Combined approach aids in diagnosis of morphologically challenging cases with molar phenotype and in detecting androgenetic cell lines in mosaic/chimeric conceptions. Human Pathol ,39; 63-72, 2008.
6. SebireJN ,Petson DR , Seckl JM , Newlands SE , Fisher AR . p57kip2. Immunochemical staining of gestational trophoblastic tumors does not identify the type of causative pregnancy. Histopathology, 45; 135-41, 2004.
7. LeGallu RD , Stelow EB , Ramixz NC , Atkins KA , Diagnosis of H.moles using p57 IHC and HER2 Fluorescent insitu hybridization. Am J clinPathol , 129;749-55,2008.
8. Szulman AE, Surti U. The syndrome of H.mole cytogenetic and morphological correlations I .Am J obstetGynaecol , 131 ; 665-71 ,1978.
9. SzulmanAE ,Surti U . The syndromes of hydatidiform mole II.Morphological evolution of the complete and partial mole. Am J obstetGynaecol ,132 ; 20-7 ,1978.
10. Di CintioE ,Parazzini F, Rosa C , Chatenoud L , Benzi G .” The epidemiology of gestational trophoblastic disease “. Gen DiagnPathol ,143 (2-3); 103-8, 1997.
11. JaffarRozina, KalsoomRahat and QuershiAsmaa. Histopathological review of partial and complete hydatiform moles in a tertiary care hospital , Lahore. 27 ,76-80; 2011.
12. Nizam K, Haider G, Memon N, Haider A. Gestational trophoblastic disease. Experience at NawabshahHospital . J Ayub Med Coll .21; 2009.
13. Koirala A, Khatiwada P, Giri A , Kandel P, Rigmi M, Upreti D. The demographiesof molar pregnancy in BPKIHS, Kathmandu Univ Med J ,36(4); 298-300;2011.
14. Mayun AA, Rafindadi AH , Shehu MS. Pathomorphology of molar gestation in Zaria. 51(1) ; 1-4, 2010.
Published
2016-01-21
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