Role of Complements and Immunoglobulins in Type 1 Diabetes Mellitus

  • Shailja Singh "Banaras Hindu University"
  • Usha Singh "Banaras Hindu University"
  • N K Agrawal "Banaras Hindu University"
  • R G Singh "Banaras Hindu University"
Keywords: Diabetes Mellitus, Immunoglobulin, Complement.

Abstract

Background: The aim of the present study was to determine the role of complements and immunoglobulins in normal healthy population and patients having Type 1 diabetes mellitus (T1DM).Methods: A total of 26 patients with T1DM and 20 healthy controls were included in the study. The sample was collected from OPD of Department of Endocrinology, SS Hospital, IMS, BHU, Varanasi. Immunoglobulins and complements estimation was done by turbidometry method. Result: A total of 26 patients with T1DM between 8 yrs to 33 yrs age were studied. Out of 26 cases, 19.2% cases had low C4 and 3.9% had elevated serum C4 value. Mean value of serum C4 was significantly reduced in T1DM.  The patients having low C4 value belonged to the age group less than 18 years. About 23.1% DM patient had increased serum IgM levels and 7.7% had increased serum IgA levels. But only rise of IgM was statistically significant. C3 and IgG in DM patients were within normal range. There was significant positive correlation of serum C4 with increase BMI. IgA was significantly correlated with rising of BMI and low age of onset of T1DM.Conclusion: Our study concludes that C4 deficiency associated with Type I DM. The study also showed that increased IgM  which may be due to recent infection.

Author Biographies

Shailja Singh, "Banaras Hindu University"
Shailja Singh is a Ph.D. Student in the Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi. She has published many research paper in various journals and also presented various paper in national and international conferences.
Usha Singh, "Banaras Hindu University"
Dr. Usha Singh is a Professor and Incharge in the UGC Advanced Immunodiagnostic Training & Research Centre, Department of Pathology,  Institute of Medical Sciences, Banaras Hindu University, Varanasi,  UP, India. She has published many research paper in various International and National journals.
N K Agrawal, "Banaras Hindu University"
Dr. N. K. Agrawal is a Professor in the Department of Endocrinology and Metabolism,  Institute of Medical Sciences, Banaras Hindu University, Varanasi,  UP, India. He has published many research paper in various International and National journals.
R G Singh, "Banaras Hindu University"
Dr. R. G. Singh is a Distinguished Professor in the Department of Nephrology,  Institute of Medical Sciences, Banaras Hindu University, Varanasi,  UP, India. He has published many research paper in various International and National journals.

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Published
2016-02-13
Issue
Vol 3 No 1 (2016)
Section
Original Article

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