Diagnostic role of IL-6 in Neonatal sepsis

  • Neeraj Kumar SN MEDICAL College agra
  • Manoj Kumar Singh S N Medical College Agra
  • Rajeshwar Dayal S N Medical College Agra
  • Shikha Gupta S N Medical College Agra
  • Ruchika Garg S N Medical College Agra
Keywords: Sepsis, IL-6, CRP, Neonatal

Abstract

Background: Neonatal sepsis is a serious life-threatening condition with high mortality. The early and accurate diagnosis of sepsis is one of main challenge for prevention of mortality due to sepsis in NICUs. A great effort to reduce the neonatal mortality rate is put into looking for new reliable biomarkers. Among various biomarkers, IL-6 could be promising and reliable biomarker for early diagnosis of neonatal sepsis.Objective: To evaluate the diagnostic value of  IL-6 in Neonatal Sepsis.Design: Prospective, observational study.Methodology: By ELISA method the level of serum IL-6 were assessed in 41 neonates with suspected sepsis and 42 healthy neonates with no clinical and laboratory data of infection.Result: The AUC for IL-6 and CRP were 0.87, 0.80 respectively. The cut off value for IL-6 was 181pg/ml at which the sensitivity, specificity, PPV and NPV were 80.1%, 85.7%, 84.6%, 81.8% respectively. The cut off value for CRP is 3.78 mg/dl at which the sensitivity, specificity, PPV and NPV are 61%, 90.5%, 86.2%, 70.3% respectively. In culture positive patients sensitivity of IL-6 and CRP was 90% and 80%, respectively. In culture negative patients sensitivity of  IL-6 and CRP was  71.4% and 42.8%, respectively. In EOS sensitivity  of IL-6 and CRP was 86.3% and 50%, respectively. In LOS  sensitivity of  IL-6 and CRP was 73.6% and 72.6%, respectively.Conclusion: IL-6 is a novel biomarker with high sensitivity and good specificity for sepsis. This has better diagnostic value than CRP, especially in Blood culture negative and EOS.  

Author Biographies

Neeraj Kumar, SN MEDICAL College agra
associate ProfessorDepartment of Pediatrics
Manoj Kumar Singh, S N Medical College Agra
Assistant professor in department of pediatrics
Rajeshwar Dayal, S N Medical College Agra
professor and head in department of pediatrics
Shikha Gupta, S N Medical College Agra
junior resident-3
Ruchika Garg, S N Medical College Agra
assistant professor in department of obg and gynecology

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Published
2016-02-13
Section
Original Article