Patterns and Demographic Distribution of Hemoglobinopathies in North Maharashtra
Keywords:
Hemoglobinopathies, Sickle Cell Anaemia, Thalassemia, HPLC.
Abstract
Background: The main aim of the study is to determine patterns and demographic distribution of hemoglobinopathies in North Maharashtra using HPLC testing system. Another aim is to find the categories at high risk of hemoglobinopathies in North Maharashtra.Methods: It is a prospective study carried out in GMC Dhule over a period of 6 years. Here patients come from Dhule, Nandurbar,Nashik & Jalgaon districts having high prevalence rate of sickle cell anaemia. A total 10081 patients included in the study. All the samples were sent for HPLC study.Result: A female preponderance was noted (54%). The most common age group was below 20yrs (73%). Hemoglobinopathies were most prevalent in ST category (79%), followed by OBC category (8%). The most common abnormal haemoglobin pattern detected was SA (63.1%), followed by SS (6.6%). Prevalence of Beta thalassemia heterozygous was2.3% .Conclusion: Pawara and Bhill community formed the major chunk of this study in whom sickle cell disorders are common. Prevalence of Beta heterozygous thalassemia in this study was 2.3%, which in contrast to other studies is much less. This might be due to demographic variation as this area shows prevalence of sickle cell disorder. HPLC has helped in identification of compound heterozygous disorders like SA-BTT, SA-HBQ India, SA- Hereditary persistance of fetal Hb, HBE-BTT and HBD-SA. To the best of our knowledge, it is the first of its kind study reported from North Maharashtra.References
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19. Eman A. Ajjack, Hiba A. Awooda etal. Hemoglobin patterns in Patients with Sickle Cell Hemoglobinopathies. International Journal of Haematological Disorders,2014;1(1):8-11.
20. Kate SL, Lingojwar DP. Epidemiology of Suckle Cell Disorder in the State of Maharashtra. Int J Gene 2002; 2(3):161-167.
21. Kar B C, Devis, Clinical profile of sickle cell disease in Orissa. Indian journal of Pediatric, 64:73- 77,(1997).
22. Kate SL, Health problems of tribal population groups from the state of Maharashtra. 2000; Oct 23rd: 1 to 9 from Immunology Bulletin.
2. Angastinosis M, Modell B. Global epidemiologyof hemoglobin disorders. Proc Natl Acad Sci USA 1998; 850: 251.
3. Wilson M, Forsyth P, Whiteside J: Haemoglobinopathy and sickle cell disease. Continuing Education in Anaesthesia, Critical Care & Pain 2009, 10.
4. Kate S L Health problems of tribal population groups from state of Maharashtra Ind J Med Sci 2001; 5(2): 99-108.
5. 3 Lele R d, Solanki B R, Bhagwat R B, Hemoglobinopathies in Aurangabad region. Journal Association Physicians India 10:263
6. Herrick J: Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. Arch Intern Med 1910, 6: 517-521.
7. Serjeant GR, Serjeant BE: Sickle Cell Disease, 3rd edn: Oxford: Oxford University Press.; 2001.
8. 8.Balgir RS. The burden of hemoglobinopathies in India and the challenges ahead. Curr Sci 2000; 79:1536-1547.
9. Balgir RS. The genetic burden ofhemoglobinopathies with special reference tocommunity health in India and the challengahead. Indian J Hematol Blood Transfus 2002;20: 2-7.
10. Balgir RS. Spectrum of hemoglobinopathies inthe state of Orissa, India : A ten years cohort study. J Assoc Physicians India 2005; 53:1021-1026.
11. Verma IC. Burden of genetic disorders in India. Indian J Paediatr2000;67:893–8.
12. Verma IC, Choudhury VP, Jain PK. Prevention of thalassemia : a necessity in India. Indian J Pediatr 1992; 59: 649-654.
13. Manglani M, Lokeshwar MR, Vani VG, BhatiaN, Mhaskar V. ‘ NESTROFT-an effective test for b-thalassemia trait. Indian Pediatr 1997; 34: 703 -708.
14. Wild BJ, Bain BJ. Investigation of abnormalhemoglobins and thalassemia. In: Lewis SM, Bain BJ, Bates I (Eds.), Dacie and Lewis Practical Hematology, 9th Edition. London :Churchill Livingstone. 2001; 231-268.
15. Chouhan V. Epidemiology: symposium on thalssaemia. Indian J Hematol Blood Transf 1992;10:1–20.
16. M. Mesbah Uddin etal. Pattern of B- Thalassemia and other haemoglobinopathies: A cross- Sectional Study in Bangladesh. International Scholarly Research Network ISRN Hematology 2012;659191:1-6
17. Mannan A, J Kawsar etal. A demographic approach for understanding the prevalence of B Thalassemia Patterns and other hemoglobinopathies: Selective Study in Chittagong City Perspective. Asian Journal of Biological Sciences 2013;6(2): 124-130.
18. Bhasin MK, Walter H, Danker-Hopfe H. Glucose-6-phosphate dehydrogenase deficiency and abnormal hemoglobins (S andE) in people of India. J Hum Ecol 1994;3:131-59
19. Eman A. Ajjack, Hiba A. Awooda etal. Hemoglobin patterns in Patients with Sickle Cell Hemoglobinopathies. International Journal of Haematological Disorders,2014;1(1):8-11.
20. Kate SL, Lingojwar DP. Epidemiology of Suckle Cell Disorder in the State of Maharashtra. Int J Gene 2002; 2(3):161-167.
21. Kar B C, Devis, Clinical profile of sickle cell disease in Orissa. Indian journal of Pediatric, 64:73- 77,(1997).
22. Kate SL, Health problems of tribal population groups from the state of Maharashtra. 2000; Oct 23rd: 1 to 9 from Immunology Bulletin.
Published
2016-06-01
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