ROUND CELL VARIANT OF MYXOID LIPOSARCOMA IN A YOUNG FEMALE AT ELBOW : A CASE REPORT
Keywords:
Lipoblast, MLS, MRCLS, Myxoid, Round cell, Mesenchymal
Abstract
Round cell variant of myxoid liposarcoma (MRCLS) is a type of liposarcoma though classified separately(WHO),shares common clinical& morphological features. As compare with other types, this variant has younger onset with peak at 35-55 years with male predominance. It predomintly affects limbs particularily thigh & rarely arises from retroperitoneum & subcutaneous tissue. Presence of more round cells in myxoid background (hypercellularity) pointed towards bad prognosis. We are here reporting a case of round cell variant of myxoid liposarcoma in 30 years female, diagnosed in histopathology, composed of uniform spindle cells, round cells with signet ring lipoblasts in prominent background of myxoid stroma with plexiform vasculature, which ,was negative in the cytology. CT scan shows, soft tissue density mass in the subcutaneous area of the right elbow. The presentation of our case is unique in the regard that, age,sex & the site (extensor surface of elbow), where minimal fatty tissue presents.References
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2. Enzinger FM and Weiss SW eds. General considerations. In Soft Tissue Tumors, Third Edition. St. Louis, 1995, Mosby, pp 1-16.
3. Lewis JJ, Brennan MF. Soft tissue sarcomas. Curr Probl Surg 1996; 3:817-871.
4. Peterson JJ, Kransdorf MJ, Bancroft LW, O’Connor MI. Malignant fatty tumors: classification, clinical course, imaging appearance and treatment. Skeletal Radiology 2003; 32:493-503.
5. Coffin CM. Adipose and myxoid tumors. In Pediatric Soft Tissue Tumors: A Clinical, Pathological, and The-rapeutic Approach, Coffin CM, Dehner LP and O’Shea PA eds. Baltimore, 1997, Williams and Wilkins, pp 254-276.
6. Pisters PW, Harrison LB, Leung DH, et al: Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol 1996:14:859-68.
7. Gebhardt MD, peter J, Buecker MD. A global initiative for liposarcoma. The Liddy shrivers sarcoma initiative “liposarcoma a detailed review” by mark. PP 1-30.
8. Singer S, Antonescu CR, Riedel E, et al: Histologic subtype and margin of resection predict pattern of recur-rence and survival for retroperitoneal liposarcoma. Ann Surg 2003;238:358-70
9. Fletcher DM, Bridge A Julia. WHO Classification of soft tissue and bone, 4th edition, Zurich: international agency for research on cancer ( IARC), 2013, pp 39- 40.
10. Gray W, Kocjan G. diagnostic cytopathology, 3rd edition, churchil livingston Elsevier publication, 2010, pp 777.
Published
2015-09-02
Issue
Section
Case Reports
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