A Placental Conundrum: Exaggerated Placental Site Tumor

  • Sheetal Arora Assistant Professor, Dept. of Pathology, VMMC and Safdarjung Hospital, New Delhi
  • Sujata Raychaudhuri
  • Deepshikha Rana
Keywords: Exaggerated placental site, intermediate trophoblast cells, Myometrium

Abstract

Exaggerated placental site (EPS) is defined as a non-neoplastic condition in which there is proliferation of number of implantation site intermediate trophoblastic cells that infiltrates the endometrium and myometrium. This is a benign lesion and it’s an exaggeration of normal physiological process as the intermediate trophoblastic cells present in EPS are similar morphologically and immunophenotypically to those found in the normal implantation site. An exaggerated placental site may occur in association with normal pregnancy or an abortion. The significance of reporting this lesion lies in the fact that the cells of this lesion display an identical morphological features to the intermediate trophoblastic cells found in placental site trophoblastic tumour, placental site nodule & epithelioid trophoblastic tumour. To confirm the morphological analysis, we used immunohistochemistry panel comprising of Cytokeratin 18, p63 and ki-67(MIB-1). We here present a rare case of an exaggerated placental site in a 30-year-old female who was in her first trimester of pregnancy and presented with signs of incomplete abortion.  DOI: 10.21276/AWCH.1808

References

1.Ozdemir O, Sari ME, Selimova V, Ilgin BU, Atalay CR. 2014, ‘A case report of complete mole with co-existent exaggerated placental site reaction and review of the literature’, Niger Med J. 2014;55(2):2014, pp. 180-2.
2.Shih IM, Kurman RJ. The pathology of intermediate trophoblastic tumors and tumor-like lesions. Int J Gynecol Pathol. 2001;20(1):31-47.
3. Sitolnicu S, Radulescu D, Gonzalez-Rocha T, Timar I, Puscasiu L, Nogales FF. Exaggereted plasental site lesion with unusual presentation in the cerviks of a perimenopasual patient. APMIS. 2008; 116:160-162.
4. Baergen RN, Rutgers JL. Trophoblastic lesions of the placental site. Gen Diagn Pathol. 1997;143(2-3):143-158.
5. Fisher SJ, Damsky CH. Human cytotrophoblast invasion. Semin Cell Biol. 1993;4(3):183-188.
6. Choi JJ, Emmadi R. Incidental placental site nodule in a fallopian tube. Int J Surg Pathol. 2014;22(1):90- 2.
7.Benischke K, Kaufmann P. In Trophoblastic neoplasms. Pathology of the human placenta 4th edition, Germany, Springer. 2000:754-767.
8.Jacob S, Mohapatra D. Placental site nodule: a tumor-like trophoblastic lesion. Indian J Pathol Microbiol. 2009;52(2):240-1
Published
2017-12-15
Issue
Vol 3 No 4 (2017)
Section
Case Reports

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).