A Placental Conundrum: Exaggerated Placental Site Tumor

  • Sheetal Arora Assistant Professor, Dept. of Pathology, VMMC and Safdarjung Hospital, New Delhi
  • Sujata Raychaudhuri
  • Deepshikha Rana
Keywords: Exaggerated placental site, intermediate trophoblast cells, Myometrium


Exaggerated placental site (EPS) is defined as a non-neoplastic condition in which there is proliferation of number of implantation site intermediate trophoblastic cells that infiltrates the endometrium and myometrium. This is a benign lesion and it’s an exaggeration of normal physiological process as the intermediate trophoblastic cells present in EPS are similar morphologically and immunophenotypically to those found in the normal implantation site. An exaggerated placental site may occur in association with normal pregnancy or an abortion. The significance of reporting this lesion lies in the fact that the cells of this lesion display an identical morphological features to the intermediate trophoblastic cells found in placental site trophoblastic tumour, placental site nodule & epithelioid trophoblastic tumour. To confirm the morphological analysis, we used immunohistochemistry panel comprising of Cytokeratin 18, p63 and ki-67(MIB-1). We here present a rare case of an exaggerated placental site in a 30-year-old female who was in her first trimester of pregnancy and presented with signs of incomplete abortion.  DOI: 10.21276/AWCH.1808


1.Ozdemir O, Sari ME, Selimova V, Ilgin BU, Atalay CR. 2014, ‘A case report of complete mole with co-existent exaggerated placental site reaction and review of the literature’, Niger Med J. 2014;55(2):2014, pp. 180-2.
2.Shih IM, Kurman RJ. The pathology of intermediate trophoblastic tumors and tumor-like lesions. Int J Gynecol Pathol. 2001;20(1):31-47.
3. Sitolnicu S, Radulescu D, Gonzalez-Rocha T, Timar I, Puscasiu L, Nogales FF. Exaggereted plasental site lesion with unusual presentation in the cerviks of a perimenopasual patient. APMIS. 2008; 116:160-162.
4. Baergen RN, Rutgers JL. Trophoblastic lesions of the placental site. Gen Diagn Pathol. 1997;143(2-3):143-158.
5. Fisher SJ, Damsky CH. Human cytotrophoblast invasion. Semin Cell Biol. 1993;4(3):183-188.
6. Choi JJ, Emmadi R. Incidental placental site nodule in a fallopian tube. Int J Surg Pathol. 2014;22(1):90- 2.
7.Benischke K, Kaufmann P. In Trophoblastic neoplasms. Pathology of the human placenta 4th edition, Germany, Springer. 2000:754-767.
8.Jacob S, Mohapatra D. Placental site nodule: a tumor-like trophoblastic lesion. Indian J Pathol Microbiol. 2009;52(2):240-1
Case Reports