Chikungunya in Children: A Study Conducted in Hospitalised Patients During 2016 Epidemic in Delhi
Keywords:
Chikungunya fever, children, epidemic, fever, Delhi
Abstract
Chikungunya fever is caused by Chikungunya virus (CHIKV)and spread by Aedes aegypti and Aedes albopictus.Clinical manifestations of chikungunya fever are variable and ranges from abrupt onset fever,skin rashes,minor haemorrhagic ,arthralgia/arthritis,vomiting,diarrhoea to severe manifestations like encephalitis,optic neuritis,seizures,retrobulbar neuritis and acute flaccid paralysis.Some clinical features are different in children and adults.This study was carried out to characterise the epidemiological,clinical,radiological and laboratory parametersalong with outcomes in all cases of chikungunya positive hospitalised children during 2016 epidemic of chikungunya in Delhi from august to november. DOI: 10.21276/awch.2017.1239References
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4.Chattopadhyay S, Mukherjee R, Nandi A, Bhattacharya N. Chikungunya virus infection in west Bengal, India. Indian J Med Microbiol 2016; 34:213 -215.
5.Patil SS, Patil RS, Durgawale PM, Patil AG. A stydy of the outbreak of chikungunya fever. J Clin Diagn Res 2013; 7(6): 1059 – 1062.
6.Kalantri SP, Joshi R, Riley LW. Chikungunya epidemic: An Indian perspective. The National Med J India 2006; 19:315 – 22.
7.Suryawanshi SD, Dube A H, Khadse Reveal K, Jalgaonkar S V, Sathe P S, Zawar S D, Holay MP. Clinical profile of chikungunya fever in patients in a tertiary care centre in Maharahtra, India. Indian J Med Res 2009; 129: 438 – 441.
8.Mavalankar D, Shastri P, Bandyopadhyay T, Parmar J, Ramani K V. Increased mortality rate associated with chikungunya epidemic, Ahmedabad, India. Emerging infec Dis 2008; 14(3): 412 – 415.
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11.Nicole R, Markus H, Patrick G. Chikungunya in children. The Ped Inf Dis J 2015; 34(7): 789 – 791
12.Swaroop A, Jain A, Kumhar M, Parihar N, Jain S. Chikungunya fever. JIACM 2007; 8: 164 – 168.
13.Valanparampil J, Chirakkarot S, Letha S, Jayakumar C, Gopinathan KM. Clinical profile of chikungunya in infants. Ind J Ped 2009; 76: 151 – 155.
14.Afzal MF,Naqvi SQ,Sultan MA,Hanif A. Chikungunya fever among children presenting with non specific febrile illness during an epidemic of dengue fever in Lahore,Pakistan. Merit Res J Med Sci 2015;3(3):069-073
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16.Guidelines on clinical management of chikungunya fever by WHO,oct 2008. http:// www.wpro.who.int/mVp/topics/ntd/clinical management assessed on 9 December 2016.
17.Mangalgi SM, shenoy S, Maralusiddappa PG, Aprameya IV. Neonatal chikungunya - A case series J.Ped Sci 2011; 3(2) : e 74.
18.Teng TS, Kam YW, Lee B, Hapuarachchi HC, Wimal A, NG LC, Ng LF. A systematic meta - analysis of immune signatures in patients with acute chikungunya virus infection. J. infect dises 2015; 211: 1925 - 1935.
19.Simarmata D, Ng DCE, Kam YW, Lee B, Sum MSH, Her Z, chow A et al. Early clearance of chikungunya virus in children is associated with a strong innate immune response. Sci Rep 2016; 6, 26097.
20.Malik S, Mehta KD, Singh KP, Dhole TN. Emergence of chikungunya infection in North India. Arch pathol lab Med 2016 (12); 3(4): 314 - 319.
21.Chew LP, Chua HH. Outbreak of chikungunya in Johar Bahru, Malaysia. Clinical and laboratory features of hospitalised patients. Med J Malaysia 2009; 64(3): 220 - 222.
22.Taraphdar D, Roy BK, Chatterjee S. Chikungunya virus infection amongst the acute encephalites symdrome cases in West Bengal, India. Indian J Medical Microbiol 2015; 33, Supple S1: 153 - 6
23.S Robin, Ramful D, Jaffar - Bandijee MC, Rigou G, Alessandri JL, Neurologic manifestations of pediatric chikungunya infection, J child neurol 2008 (7); 23(9): 1028 - 1035.
24.Chusri S, Siripceitoon P, Hirunpat S, Silpapojakul V. Case reports of neuro chikungunya in Southern Thailand. Am J Trop Med Hyg. 2011(8); 85(2): 386 - 9
25.Martins HA del, Bernardino SN, Santos CC, Ribas VR, Valenca MM. Neuro - Chikungunya : a review. Med Res. Arch 2016(9); 4(5): 1-12
26.L Penny, V Rair, Osbome JC, Begum A, Platnk JLM, Shankar MV, Hewson Roger et al. Chikungunya virus and central nervous system infections in children, India. Emergence infect Dis 2009 (2); 15(2): 329 - 331
27.Mittal A, Mittal S, Bharati MJ, Ramakrishnan R, Sarwanan S, Sathe PS. Optic neuritis associated with chikungunya virus infection in South India. Arch ophthalmol 2007, oct; 125 (10) : 1381 - 6
28.Malik S, Mehta KD, Singh KP, Dhole TN. Emergence of chikungunya infection in North India. 2016, oct - Dec: 3(4) : 314 - 319.
2.Chhabra M. Mittal V, Bhattacharya D, RanaUVS, Lal S. Chikungunya fever : A re-emerging viral infection. India J Med Microbial 2008; 26: 5-12.
3.Karthikyan M, Deepa K.M. A study on chikungunya cases in Palakkad, India. Acta Medica Medianae 2011, 50 (1) : 17 – 20.
4.Chattopadhyay S, Mukherjee R, Nandi A, Bhattacharya N. Chikungunya virus infection in west Bengal, India. Indian J Med Microbiol 2016; 34:213 -215.
5.Patil SS, Patil RS, Durgawale PM, Patil AG. A stydy of the outbreak of chikungunya fever. J Clin Diagn Res 2013; 7(6): 1059 – 1062.
6.Kalantri SP, Joshi R, Riley LW. Chikungunya epidemic: An Indian perspective. The National Med J India 2006; 19:315 – 22.
7.Suryawanshi SD, Dube A H, Khadse Reveal K, Jalgaonkar S V, Sathe P S, Zawar S D, Holay MP. Clinical profile of chikungunya fever in patients in a tertiary care centre in Maharahtra, India. Indian J Med Res 2009; 129: 438 – 441.
8.Mavalankar D, Shastri P, Bandyopadhyay T, Parmar J, Ramani K V. Increased mortality rate associated with chikungunya epidemic, Ahmedabad, India. Emerging infec Dis 2008; 14(3): 412 – 415.
9.Bhatnagar P K, Garg S K, Bano T, Jain S. knowledge, attitude and practice regarding Dengue and Chikungunya in secondary school children in a city of north india Eurp J PharmMed Res 2016; 3(11): 423 – 428.
10.Sebastian MR, Lodha R, Kabra SK. Chikungunya infection in Children. Indian J Pediatr 2009; 76:185.
11.Nicole R, Markus H, Patrick G. Chikungunya in children. The Ped Inf Dis J 2015; 34(7): 789 – 791
12.Swaroop A, Jain A, Kumhar M, Parihar N, Jain S. Chikungunya fever. JIACM 2007; 8: 164 – 168.
13.Valanparampil J, Chirakkarot S, Letha S, Jayakumar C, Gopinathan KM. Clinical profile of chikungunya in infants. Ind J Ped 2009; 76: 151 – 155.
14.Afzal MF,Naqvi SQ,Sultan MA,Hanif A. Chikungunya fever among children presenting with non specific febrile illness during an epidemic of dengue fever in Lahore,Pakistan. Merit Res J Med Sci 2015;3(3):069-073
15.Thiberville SD, Boisson V, Gaudart J,Simon F, Flahault A. Chikungunya fever: A clinical and virological investigation of outpatients of Reunion Island south- west Indian ocean. PLoS Negl Tro Dis 2004.ashyj, 7:e
16.Guidelines on clinical management of chikungunya fever by WHO,oct 2008. http:// www.wpro.who.int/mVp/topics/ntd/clinical management assessed on 9 December 2016.
17.Mangalgi SM, shenoy S, Maralusiddappa PG, Aprameya IV. Neonatal chikungunya - A case series J.Ped Sci 2011; 3(2) : e 74.
18.Teng TS, Kam YW, Lee B, Hapuarachchi HC, Wimal A, NG LC, Ng LF. A systematic meta - analysis of immune signatures in patients with acute chikungunya virus infection. J. infect dises 2015; 211: 1925 - 1935.
19.Simarmata D, Ng DCE, Kam YW, Lee B, Sum MSH, Her Z, chow A et al. Early clearance of chikungunya virus in children is associated with a strong innate immune response. Sci Rep 2016; 6, 26097.
20.Malik S, Mehta KD, Singh KP, Dhole TN. Emergence of chikungunya infection in North India. Arch pathol lab Med 2016 (12); 3(4): 314 - 319.
21.Chew LP, Chua HH. Outbreak of chikungunya in Johar Bahru, Malaysia. Clinical and laboratory features of hospitalised patients. Med J Malaysia 2009; 64(3): 220 - 222.
22.Taraphdar D, Roy BK, Chatterjee S. Chikungunya virus infection amongst the acute encephalites symdrome cases in West Bengal, India. Indian J Medical Microbiol 2015; 33, Supple S1: 153 - 6
23.S Robin, Ramful D, Jaffar - Bandijee MC, Rigou G, Alessandri JL, Neurologic manifestations of pediatric chikungunya infection, J child neurol 2008 (7); 23(9): 1028 - 1035.
24.Chusri S, Siripceitoon P, Hirunpat S, Silpapojakul V. Case reports of neuro chikungunya in Southern Thailand. Am J Trop Med Hyg. 2011(8); 85(2): 386 - 9
25.Martins HA del, Bernardino SN, Santos CC, Ribas VR, Valenca MM. Neuro - Chikungunya : a review. Med Res. Arch 2016(9); 4(5): 1-12
26.L Penny, V Rair, Osbome JC, Begum A, Platnk JLM, Shankar MV, Hewson Roger et al. Chikungunya virus and central nervous system infections in children, India. Emergence infect Dis 2009 (2); 15(2): 329 - 331
27.Mittal A, Mittal S, Bharati MJ, Ramakrishnan R, Sarwanan S, Sathe PS. Optic neuritis associated with chikungunya virus infection in South India. Arch ophthalmol 2007, oct; 125 (10) : 1381 - 6
28.Malik S, Mehta KD, Singh KP, Dhole TN. Emergence of chikungunya infection in North India. 2016, oct - Dec: 3(4) : 314 - 319.
Published
2017-01-21
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