Castleman Disease- An Uncommon And Intriguing Condition Revisited: A Report Of Two Cases
Castleman disease (CD) also called as angiofollicular hyperplasia or giant lymph node hyperplasia of unknown cause is a benign lymphoproliferative disorder. It is a localised (unicentric) or disseminated (multicentric) disease. This disease is uncommon with an incidence of 25 cases per million person per year. Castleman disease is a heterogeneous group of disorders with four characteristic histological variants. The etiology of this disease is poorly understood.
We report two cases of CD, one presenting with a neck mass and the other presenting with para-aortic and mesenteric lymphadenopathy which were classified as hyaline vascular type and mixed type of CD respectively.
Johkoh T, Muller NL, Ichikado K, et al. Intrathoracic multicentric Castleman disease: CT findings in 12 patients. Radiology 1998; 209: 477-481.
Castleman B, Iverson L, Menendez VP. Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer 1956; 9: 822-830.
Castleman B, Towne VW. Case records of the Massachusetts General Hospital: Case No. 40231. N Engl J Med 1954; 250: 1001-1005.
Cervantes C E, Correa R. Castleman disease: A rare condition with endocrine manifestations. Cureus 2015; 7: e380.
Frizzera G, Banks PM, Massarelli G, Rosai J. A systemic lymphoproliferative disorder with morphologic features of Castleman’s disease. Pathological findings in 15 patients. Am J Surg Pathol 1983; 7: 211-231.
Saeed-Abdul-Rahman I, Al-Amri AM. Castleman disease. The Kor J Hematol. 2012;47:163-77.
Halac M, Ergul N, Sager S, Demir A, Buyukpinarbasli N, Sonmezoglu K. PET/CT findings in a multicentric form of Castleman’s disease. Hell J Nucl Med. 2007 Sep 3;10:172-4.
Chan KL, Lade S, Prince HM, Harrison SJ. “Update and new approaches in the treatment of Castleman’s disease,” J Blood Med 2016;7:145–158.
Hsu MY, Ng KK, Ko SF, Cheung YC, Lui KW, Wang JJ, Chan SC, Jung SM, Ng SH. Multicentric Plasma Cell Castleman’s disease associated with POEMS syndrome. Chin J Radiol 2009;34:113-7.
Gaba AR., Stein RS., Sweet DL, Variakojis D. Multicentric giant lymph node hyperplasia. Am J Clin Pathol. 1978;69:86–90.
Iyer S, Bhatti MI, Halliday M. Castleman's disease—A case report. Int J of Sur Case Reports. 2010; 31:25-6.
Menezes BF, Morgan R, Azad M. Multicentric Castleman's disease: a case report. J Med Case Reports. 2007; 1(1):78.
Mylona EE, Baraboutis IG, Lekakis LJ, Georgiou O, Papastamopoulos V, Skoutelis A. Multicentric Castleman's disease in HIV infection: a systematic review of the literature. AIDS Rev 2008;10(1):25-35.
Filliatre-Clement L, Busby-Venner H, Moulin C, Roth-Guepin G, Perrot A. Hodgkin lymphoma and Castleman disease: when one blood disease can hide another. Case Reports in Hematology 2017; Article ID 9423205 pg 1-3.
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