Serum Cystatin C compared with conventional renal function tests: A study in patients with pre-eclampsia

  • Shalvi Sharma Hindu Rao Hospital
  • Rajiv Kumar Ranjan Hindu Rao Hospital
  • Mamta Gupta Hindu Rao Hospital
  • Anjana Singh Hindu Rao Hospital
  • Ruchika Gupta All India Institute of Medical Sciences
  • Leela Pant Hindu Rao Hospital
  • Sompal Singh Hindu Rao Hospital
Keywords: Cystatin C, Pregnancy, Pre-eclampsia, Creatinine, Uric acid


Objective: The aim of this study was to evaluate the value of serum cystatin C in assessment of renal function and compare with conventional renal function tests.Methods: For this study, 30 females with pre-eclampsia (cases) and 30 healthy pregnant females (controls) were included from antenatal clinics. Venous blood samples were collected for estimation of cystatin C, creatinine, urea, uric acid, lipid profile, protein, albumin, blood sugar and glycosylated hemoglobin. Spot urine samples were taken for measurement of microalbumin and creatinine. Appropriate statistical tests were applied for significance of difference.Results: Serum levels of cystatin C and uric acid were significantly higher in cases (P value <0.001 and 0.002, respectively) compared to controls. Urinary microalbumin-creatinine ratio also showed highly significant difference between cases and controls. However, renal function markers like urea and creatinine did not show any difference between the healthy pregnant females and pre-eclamptic patients.Conclusion: Serum cystatin C appears to be a superior marker of renal function compared to creatinine in patients with pre-eclampsia and showed be routinely included in the investigative work-up of these patients.

Author Biographies

Shalvi Sharma, Hindu Rao Hospital
Department of Biochemistry
Rajiv Kumar Ranjan, Hindu Rao Hospital
SpecialistDepartment of Biochemistry
Mamta Gupta, Hindu Rao Hospital
Department of Gynecology & Obstetrics
Anjana Singh, Hindu Rao Hospital
ResidentDepartment of Biochemistry
Ruchika Gupta, All India Institute of Medical Sciences
Senior Research AssociateDepartment of Pathology
Leela Pant, Hindu Rao Hospital
SpecialistDepartment of Pathology
Sompal Singh, Hindu Rao Hospital
SpecialistDepartment of Pathology


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Original Article