Histomorphological Spectrum of Bone Tumors in A Tertiary Care Hospital
Keywords:
bone tumors, primary, metastatic, malignant, Histopathology
Abstract
Background: Bone tumors are relatively uncommon, constituting only 0.5% of all types of cancer. Many bone tumor entities show a remarkable consistency in clinical presentation, age and anatomic site distribution. The final diagnosis of bone tumors should be based on an integrated use of histopathologic findings, clinical presentation, and imaging characteristics. Immunohistochemical and genetic/molecular techniques are at times crucial for the definite classification of certain bone tumors. Objective: The aim of the present study was to determine the spectrum, frequency and demographics of bone tumors at our institute Santokba Durlabhji Memorial Hospital, Jaipur. Materials and Method: A retrospective review of histopathological reports of all bone specimens received in the department of pathology (histopathology section) for a period of 3 years from January 2014 to January 2017 Results: On histopathological diagnosis, among neoplastic lesions incidence of benign tumors was 447 cases (60.4%), and malignant tumors was 293cases (39.6 %). Among the benign tumors, the most common benign tumor was Giant cell tumor 99 cases (13.3%). Osteosarcoma was commonest malignant tumor 42 cases (5.6%). Maximum number of bone tumors occurred in 15-45 years of age and the male to female ratio was 2:1 Conclusions: Bone tumors occurred predominantly within 15-45 years of age with a male preponderance. Giant cell tumor was the most common benign tumor, while Osteosarcoma was the most common malignant bone tumor. Femur is the most common site for bone tumors.References
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19. Rao VS, Pai MR, Rao RC, Adhikary MM. Incidence of primary bone tumours and tumour like lesions in and around Dakshina Kannada district of Karnataka. J Indian Med Assoc 1996; 94:103-4.
2. Rhutso Y, Laishram R S, Sharma L DC, Debnath K. Histopathological evaluation of bone tumors in a tertiary care hospital in Manipur,India. India. J Med Soc 2013;27:135-9
3. O’Donnell P. Evaluation of focal bone lesions. Basic principles & clinical scenarios. Imaging 2003;15: 298
4. Manaster BJ. Tumors. In: Manaster BJ, Disler DG, May DA, eds. Musculoskeletal Imaging: The Requisites, 2nd edition, St. Louis, MO: Mosby; 2002, p. 1-104
5. Modi D, Rathod GB, Delwadia KN, Goswami HM. Histopathological study of bone lesions - A review of 102 cases. IAIM, 2016; 3(4): 27-36
6. Rosenberg AE. Bones. In: Kumar V, Abbas AK,Fausto N, editors. Robbins and Cotran. Pathologic basis of disease. 7th ed. Philadelphia: Elsevier saunders; 2005: 1273-324.
7. Settakorn J,Lekawanvijit S , Arpornchayanon O, Rangdaeng S, Vanitanakom P et al. Spectrum of Bone Tumors in Chiang Mai University Hospital, Thailand According to WHO Classification 2002: A Study of 1,001 Cases. J Med Assoc Thai 2006 ;89(6):780-87
8. Gulia A, Puri A, Chorge S, Panda PK. Epidemiological data and case load spectrum of patients presenting to bone and soft tissue disease management group at a tertiary cancer center. Indian J Cancer 2016; 53: 333‑8.
9. Baena‑Ocampo Ldel C, Ramerez‑Perez E, Linares‑Gonzalez LM, Delgado Cheavez R. Epidemiology of bone tumors in Mexico City: Retrospective clinicopathologic study of 566 patients at a referral institution. Ann Diagn Pathol 2009; 13:16‑21.
10. Sarma NH, al‑Fituri O, Visweswara RN, Saeed SO. Primary bone tumor in eastern Libya‑ a 10 year study. Cent Afr J Med 1994; 40:148‑51.
11. Valdespino‑Gomez VM, Cintra‑McGlone EA, Figueroa‑Beltrán MA. Bone tumors: Their prevalence. Gac Med Mex 1990; 126:325‑34.
12. Sharma S, Mehta NP. Histopathological Study of Bone Tumors. International J of Science and Research 2015:4(12); 1970-2.
13. Rehman A, Qureshi H, Shafiullah. Bone tumors and tumor‑like lesions: 10 years retrospective analysis of biopsy results. J Postgrad Med 2004; 18:40‑5.
14. Mohammed A, Sani MA, Hezekiah IA, Enoch AA. Primary bone tumor and tumor like lesions in children in Zaria, Nigeria. Afr J Paediatr Surg 2010; 7:16‑8.
15. Kindblom L. Bone Tumors: Epidemiology, Classification, Pathology. In: Davies A., Sundaram M., James S. (eds) Imaging of Bone Tumors and Tumor-Like Lesions. Medical Radiology 2009:1-5.
16. Mohammed A, Isa HA. Pattern of primary tumor and tumor like lesions of bone in Zaria, Northern Nigeria: A review of 127 cases. West Afr J Med 2007; 26:37‑41.
17. Unni KK, Inwards CY, Bridge JA, Kindblom LG,Wold LE. Tumors of the bones and joints. AFIP Atlas of Tumor Pathology. Fourth series, Fascicle 2. Washington, DC: AFIP; 2005.
18. Jain K, Sunila, Ravishankar R, Mruthyunjaya, Rupakumar CS, Gadiyar HB, et al. Bone tumors in a tertiary care hospital of south India: A review 117 cases. Indian J Med Paediatr Oncol 2011; 32:82-5.
19. Rao VS, Pai MR, Rao RC, Adhikary MM. Incidence of primary bone tumours and tumour like lesions in and around Dakshina Kannada district of Karnataka. J Indian Med Assoc 1996; 94:103-4.
Published
2018-07-20
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