Primary pure large cell neuroendocrine carcinoma of ovary: An extremely rare entity

  • Poonam Bhaker Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 INDIA
  • Pranab Dey PGIMER, Chandigarh
  • Radhika Srinivasan PGIMER, Chandigarh
  • Subhash Chandra Saha PGIMER, Chandigarh
Keywords: Immunohistochemistry, Neuroendocrine Carcinoma, Ovary, Primary


Primary large cell neuroendocrine carcinoma of ovary is an uncommon neoplasm with an aggressive biological behaviour. These carcinomas usually occur in association with epithelial-sex cord tumours; pure form being a rarity which can pose a diagnostic difficulty. A 42 year old female presented with a large abdominal mass and pain.  Computed tomography revealed a heterogeneously enhancing solid left ovarian mass. Differential diagnoses on histopathology included large cell neuroendocrine carcinoma, carcinoid tumour, hepatoid carcinoma and malignant steroid cell tumour, not otherwise specified (NOS). Positive neuroendocrine markers including CD56, chromogranin, and NSE facilitated a correct diagnosis of large cell neuroendocrine carcinoma. Primary ovarian large cell neuroendocrine carcinomas are under-recognized aggressive tumours and must be considered as a differential in undifferentiated ovarian tumours. Histologic features and a panel of immunohistochemical stains should lead to the correct diagnosis.

Author Biographies

Pranab Dey, PGIMER, Chandigarh
ProfessorDeptt of cytology and gynaecologic pathology
Radhika Srinivasan, PGIMER, Chandigarh
ProfessorDeptt of cytology and gynaecologic pathology
Subhash Chandra Saha, PGIMER, Chandigarh
Additional Professor, Department of Gynecology and Obstetrics,


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Case Report