Small-Bowel Myeloid Sarcoma Presenting as A Relapse Case of Acute Myeloid Leukemia
Keywords:
Extramedullary, myeloblasts, acute leukemia, flow cytometry
Abstract
Granulocytic sarcoma is an extramedullary tumor of primitive granulocytic cells. It can develop at any anatomic site and is often a prelude to the development of Acute Myelogenous Leukaemia. Granulocytic sarcoma of the small intestine presents with abdominal pain and obstruction. We report a case of a 17 year old boy who presented with epigastric pain. His endoscopy revealed nodular duodenal mucosa and an area of ulcerated exophytic growth in the small bowel. Histopathology and flow cytometery confirmed the diagnosis of granulocytic sarcoma associated with acute myelogenous leukaemia. This case merits interest because of rarity of presentation and thorough clinical and laboratory work up.References
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2. Davey FR, Olson S, Kurec AS, Eastman-Abaya R, Gottlieb AJ, Mason DY. The immunophenotyping of extramedullary myeloid cell tumors in paraffin embedded tissue sections. Am T Surg Pathol 1988; 12: 699-707.
3. Brunning RD, Matutes E, Flandrin G, et al. Acute myeloid leukaemia not otherwise categorised. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. Tumours of Haematopoietic Tissues.Lyon, France: IARC Press; 2001:104–105. World Health Organization Classification of Tumours.
4. Guermazi A, Feger C, Rousselot P. Granulocytic Sarcoma (Chloroma): Imaging Findings in Adults and Children. Am J Roentgenol 2002; 178: 319-25.
5. Yamauchi K, Yasuda M. Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature. Cancer. 2002;94:1739–46.
6. Kohl SK, Aoun P. Granulocytic Sarcoma of the Small Intestine. Arch Path Lab Med 2006; 130: 1570-4.
7. Tariq G, Alia Z, Ibrahim Al N. Granulocytic sarcoma of small intestine:An unusual presentation of Acute Myelogenous Leukaemia. J Pak Med Assoc 2010;60(2) 133-36
8. Jung SH, Kim HC, Yu CS, Kim JC. Solitary preleukemic granulocytic sarcoma as a cause of small bowel obstruction. Gut Liver. 2007;1:82–86.
9. Erkut N, Vetem İ, Çobanoğlu Ü, Sönmez M. Presentation of acute myeloid myeloid leukemia preceded by myelodysplastic syndrome with multiple extramedullary infıltration: Case report. Acta Oncologica Turcica. 2009;42:121–124.
10. Martinelli G, Vianelli N, De Vivo A, et al. Granulocytic sarcomas: clinical, diagnostic, and therapeutical aspects. Leuk Lymphoma. 1997;24:349–53.
Published
2018-07-18
Issue
Section
Case Report
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