Cyto-Morphological, Biochemical and Radiological Correlation of Various Thyroid Lesions at a Tertiary Care Center

  • Bharati Bhushan Chittawadagi Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
  • T.M Karthikeyan Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
  • M Rajeshwari Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
Keywords: Cytomorphologic correlation, Thyroid FNAC, Thyroid lesions, USG Thyroid


Background: Fine needle aspiration cytology (FNAC) is a cost-effective and time saving diagnostic test used to specifically distinguish between benign and malignant lesions by cytology. Aim: To evaluate the cytomorphological pattern, thyroid hormone profile and radiological findings in early detection of various thyroid diseases. Objective: To correlate the findings of FNAC, thyroid hormone profile and radiological features in diagnosis of various thyroid lesions Methods: 100 patients with thyroid swellings underwent FNAC along with complete thyroid hormone profile& USG Thyroid. Result: 93 female and 7 male patients were evaluated. Mean age of patients was 38.62±14.2. Ninety-four patients had non-neoplastic and 6 had neoplastic lesions. Colloid goiter was the predominant group among non-neoplastic lesions, followed by Hashimoto’s thyroiditis whereas follicular neoplasm was seen more frequently among neoplastic group. Majority of patients (71%) were in euthyroid state, followed by hypothyroid state and least in hyperthyroid state. In our study 88% of benign lesions were hyper-echoic and all malignant lesions were hypo-echoic. Most of the cystic nodules were benign and showed macro-calcification whereas all malignant lesions showed micro-calcification. Most of the benign lesions showed peripheral hypervascularisation and all malignant lesions showed internal hypervascularisation. There was a statistically positive significant correlation between FNAC findings and radiological features with P<0.001. Conclusion: FNAC and radiological examination play significant role in an accurate diagnosis of neoplastic and non-neoplastic lesions of thyroid gland. Thyroid profile also plays a very important role in sub-typing of non-neoplastic lesions.

Author Biographies

Bharati Bhushan Chittawadagi, Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
Associate Professor, Department of Pathology
T.M Karthikeyan, Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
Professor & Head, Department of Pathology
M Rajeshwari, Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
Assistant Professor, Department of Community Medicine


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Original Article