A rare solid variant of primary neuroendocrine carcinoma of breast

  • Sahil I Panjvani Smt. NHL Municipal Medical College, Ahmedabad. India.
  • Minesh B Gandhi Smt. NHL Municipal Medical College, Ahmedabad. India.
  • Bhawana R Chaudhari Smt. NHL Municipal Medical College, Ahmedabad. India.
  • Ankur N Sarvaiya Smt. NHL Municipal Medical College, Ahmedabad. India.
Keywords: Neuroendocrine carcinoma, chromogranin, synaptophysin, tumor.


Solid Primary Neuroendocrine Carcinoma of Breast (NECB) is an extremely rare tumor of breast. Much less is known about it because of only few reported cases. Immunohistochemical examination showing expression of chromogranin and/or synoptophysin in more than 50% of cell population confirms evidence of neuroendocrine carcinoma. Here, we describe a case of 70-years old patient with brief review of clinopathological features, treatment and prognosis of solid NECB. Microscopy Solid islands of tumor cells are separated by fibrovascular stroma. Tumor cells are round to oval, polygonal with finely granular (stippled) nuclear chromatin with eosinophilic cytoplasm and immunohistochemistry reveal strong and cytoplasmic positivity for synaptophysin in  >50% tumor cell population. 


Feyrter F, Hartmann G. On the carcinoid growth form of the carcinoma mammae, especially the Carcinoma Solidum(Gelatinosum) mammae. Frankf Z Pathol 1963; 73:24-39.

Cubilla AL, Woodruff JM. Primary carcinoid tumor of the breast: A report of 8 patients. Am J Surg, 1977; 1: 283-292.

Lakhani S, Ellis I, Schnitt S, Tan P, van de Vijver MJ. (Eds.), WHO Classif. Tumours Breast, IARC Press, Lyon 2012, 62–63.

Wade PM, Mills SE, Read M, Cloud W, Lambert MJ, Smith RE: Small cell neuroendocrine (oat cell) carcinoma of the breast. Cancer, 1983; 52: 121-125.

Richardson RL, Weiland LH: Undifferentiated small cell carcinomas extrapulmonary sites. Semin Oncol, 1982; 9: 484-496.

Kanthan R, Negreiros F, Kanthan SC: Colonic carcinoid metastatic to the breast. Arch Pathol Lab Med, 2003; 127: 1373-1375.

Ajisaka H, Maeda K, Miwa A, Yamamoto K. Breast cancer with endocrine differentiation: Report of two cases showing different histologic patterns. Surg Today 2003; 33:909-12.

Kelly C, Henderson D, Corris P: Breast lumps: rare presentation of oat cell carcinoma of lung. J Clin Pathol, 1988; 41: 171-172.

Tsang WY, Chan JK. Endocrine ductal carcinoma in situ (E-DCIS) of the breast. Form of low grade DCIS with distinctive clinicopathologic and biologic characteristics. Am J Surg. 1996; 20:921-943.

Sapino A, Righi L, Cassoni P, Papotti M, Gugliotta P, Bussolati G. Expression of apocrine differentiation markers in neuroendocrine breast carcinomas of aged women. Mod Pathol. 2001;14: 768-776.

Rosen PP: Rosen’s Breast Pathology. Philadelphia, Lippincott-Raven 1997; 437-439.

Shin SJ, DeLellis RA, Rosen P: Small cell carcinoma of the breast: an additional immunohistochemical studies Am J Surg Pathol, 2001; 25: 831-832.

Bing Wei, Tian Ding, Yan Xing, Wei Wei, Zhen Tian, Feng Tang et al Invasive neuroendocrine carcinoma of the breast , a distinctive subtype of aggressive mammary carcinoma. Cancer 2010; 116:19: 4463-4473.
Case Report