Papillary Renal Cell Carcinoma with Extensive Osseous Metaplasia

A Case Report

  • Neelam Sharma Central Lab, Indore (MP)-India
  • Vinita Kothari Central lab, Indore (MP)-India
  • Vimal Mehta Mehta nursing home, Mandasour (MP)-India
Keywords: Papillary renal cell carcinoma, osseous metaplasia


ABSTRACT: Calcification is frequently seen histopathological and radiological finding in renal cell carcinoma (RCC). Occurrence of metaplastic bone is rare feature and majority are reported in clear cell renal cell carcinoma. We report a case of papillary renal cell carcinoma with extensive osseous metaplasia.


1. Eble JN, Sauter G, Epstein JI, Sesterhenn IA (Eds): WHO classification of tumors. Pathology and genetics of tumors of the urinary system and male genital organs. IARC press: Lyon 2004.
2. Daniel WW Jr, Hartman GW, Written DM, Farrow GM, Kelalis PP. Calcified renal masses: A review of ten year experience at the Mayo clinic. Radiology 1972;103:503-8.
3. Kwak C, Park YH, Kim IY, Moon KC, Ku JH. Expression of bone morphogenetic proteins, the subfamily of the transforming growth factor - beta superfamily, in renal cell carcinoma. J Urol 2007;178:1062-7
4. Kefeli M, Yildiz L, Aydin O, Kandemir B, Faik Yilmaz A. Chromophobe renal cell carcinoma with osseous metaplasia containing fatty bone marrow element: A case report. Pathol Res Pract 2007;203:749-2.

5. Sostre G, Johnson JF 3rd, Cho M. Ossifying renal cell carcinoma. Pediatr Radiol 1998;28: 458-60.

6. Cribbs RK, Ishaq M, Arnold M, O’Brien J, Lamb J, Frankel WL. Renal cell carcinoma with massive osseous metaplasia and bone marrow elements. Ann Diagn Pathol 1999;3:294-9.
7. Bielsa O, Lloreta J, Arango O, Serrano S, Gelabert-Mas A. Bone metaplasia in a case of bilateral renal cell carcinoma. Urol Int 2001;66:55-6.

8. Murugan P, Basu D, Manikandan R, Dorairajan LN, Kumar S. Osseous metaplasia in renal cell carcinoma: report of a rare case. Indian J Pathol Microbiol 2008;51:399-01.

9. Agarwal S, Bohara S, Jha R, Khurana N, Agarwal PN. Clear cell renal cell carcinoma with osseous metaplasia: Rare case report. J Cancer Res Ther 2015;11:1039.

10. Leung C, Trainer V, Short E, Venkatanarasimha N. A case of ossifying papillary renal
cell carcinoma. Urology 2012;80:11-2.
11. Khurram M, Tranesh G, Hamza A, Qu H. Massive Osseous Metaplasia in Papillary Renal Cell Carcinoma: A Rare Entity. Am J Clin Pathol 2015;144:320

12. Maioli H, Sharma M, Crane GM, Wu G, Miyamoto H. Renal cell carcinoma with osseous metaplasia: A case report and literature review. Integr Cancer Sci Therap 2017;4:1-4
Case Report