Histopathological Spectrum of Gall Bladder Lesions in A Tertiary Care Hospital in The Malwa Belt
A Hospital Based Study
Keywords:
Cholecystectomy, Cholecystitis, Adenocarcinoma
Abstract
Introduction: Gallbladder stones are commonest disorder among gall bladder lesions and are usually asymptomatic. Its frequency in cholecystectomy specimens is not clear. The aim of this study was to report the morphological variants and frequency of different lesions in cholecystectomy specimens. Objective: To study the various histopathological spectrum of gall bladder lesions. Materials And Methods: In present study we have studied total 141 cases of gall bladder lesion during the period of 6 months from April 2017 to October 2017 in the Dept. of Pathology at Adesh Institute of Medical Sciences and Research, Bathinda. Results: Benign lesions of gall bladder outnumbered the malignant ones with non-neoplastic lesions accounting for 93.6% (132 cases) with chronic calculous cholecystitis contributing the majority of the non-neoplastic lesions (49.64%) followed by cholesterolosis (22.69%), acalculous cholecystitis (4.96%), followed by gangrenous and xanthogranulomatous cholecystitis. Females were predominantly affected in the present study with total 107 cases out of 141 cases-75.8% cases. Most of the non-neoplastic lesions of the gall bladder lesions are common in 3rd, 4th and 5th decades of life. Neoplastic lesions of the gall bladder were common in 5th, 6th and 7th decades of life. Out of 141 cases 5 cases are of adenocarcinoma of gall bladder-3.5% of all cases. The mean age of patient with adenocarcinoma of gall bladder is 60.8 years. Conclusion: Gall bladder lesions were common indication for surgical intervention and pathological evaluation. Most of them were inflammatory lesions with cholelithiasis, however thorough examination is important as these lesions may progress to fatal malignancies.References
1. Bladder G. Extrahepatic biliary tree and ampulla. In: Mills SE, editor. Sternberg’s Diagnostic Surgical Pathology. 5th ed., Vol. II. Wolters Kluwer, 2010. p. 1600‑51.
2. Epidemiological Study of Cholelithiasis: Indian context By Dr S.R. Mhamunkar, Dr.R.D. Bapat, Ms. S.P. Mahadik, Dr. B.A. Abhyankar
3. Rosai and Ackerman’s Surgical Pathology,9th Ed. Vol I:1041.
4. Mohan H, Punia RP, Dhawan SB, Ahal S, Sekhon MS. Morphological spectrum of gallstone disease in 1100 cholecystectomies in North India. Indian J Surg 2005;67:140-2.
5. Siddiqui FG, Memon AA, Abro AH, Sasoli NA, Ahmed L. Routine histopathology of gallbladder after elective cholecystectomy of gallstones; waste of resources or justified act? BMC Surgery 2013;13(26):1-7.
6. Thamil Selvi et al. A clinicopathological study of cholecystitis with special reference to analysis of cholelithiasis. International Journal of Basic Medical Science 2011:2,68-72.
7. McCoy JJ, Vila R, Petrossian G, McCall RA, Reddy KS; Vila, et al. Xanthogranulomatous cholecystitis. Report of two cases. J S C Med Assoc. 1976;72(3):78–9.
8. Nidimusili AJ, Alraies MC, Eisa N, Alraiyes AH, Shaheen K. Leukocytosis of unknown origin: Gangrenous cholecystitis.Case Rep Med 2013; 1:1-4.
9. Kayyali A, Toumeh A, Jiang Y, Yousef W. Gangrenous cholecystitis: a case report. TranslGastrointest Cancer 2013; 2:167-9.
10. Narang A, Garg P, Bhoriwal S, Rathi V, Aggarwal S, MittalS et al. Various presentations of gangrenous cholecystitis and review of literature. Int J Surgery 2012; 28: 1-4
2. Epidemiological Study of Cholelithiasis: Indian context By Dr S.R. Mhamunkar, Dr.R.D. Bapat, Ms. S.P. Mahadik, Dr. B.A. Abhyankar
3. Rosai and Ackerman’s Surgical Pathology,9th Ed. Vol I:1041.
4. Mohan H, Punia RP, Dhawan SB, Ahal S, Sekhon MS. Morphological spectrum of gallstone disease in 1100 cholecystectomies in North India. Indian J Surg 2005;67:140-2.
5. Siddiqui FG, Memon AA, Abro AH, Sasoli NA, Ahmed L. Routine histopathology of gallbladder after elective cholecystectomy of gallstones; waste of resources or justified act? BMC Surgery 2013;13(26):1-7.
6. Thamil Selvi et al. A clinicopathological study of cholecystitis with special reference to analysis of cholelithiasis. International Journal of Basic Medical Science 2011:2,68-72.
7. McCoy JJ, Vila R, Petrossian G, McCall RA, Reddy KS; Vila, et al. Xanthogranulomatous cholecystitis. Report of two cases. J S C Med Assoc. 1976;72(3):78–9.
8. Nidimusili AJ, Alraies MC, Eisa N, Alraiyes AH, Shaheen K. Leukocytosis of unknown origin: Gangrenous cholecystitis.Case Rep Med 2013; 1:1-4.
9. Kayyali A, Toumeh A, Jiang Y, Yousef W. Gangrenous cholecystitis: a case report. TranslGastrointest Cancer 2013; 2:167-9.
10. Narang A, Garg P, Bhoriwal S, Rathi V, Aggarwal S, MittalS et al. Various presentations of gangrenous cholecystitis and review of literature. Int J Surgery 2012; 28: 1-4
Published
2018-11-28
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