Fibrinogen and D Dimer in Healthy Nigerian Women on Hormonal Contraceptives

  • Sani Bako Abubakar Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria
  • Aisha Indo Mamman Transfusion Ahmadu Bello University Teaching Hospital Zaria, Nigeria
  • Muhammad Adogie Abdul Ahmadu Bello University Teaching Hospital Zaria, Nigeria
  • Muhammad Zainu Sabitu Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria
Keywords: fibrinogen, D dimer, hormornal contraceptive, haemostasis


Introduction: Hormonal contraceptives have been associated with increased tendency of thromboembolic disorders. However, a balance between fibrin generation and fibrinolytic activity has been shown to minimize the risk. The aim of the study was to assess the serum fibrinogen and D-Dimer level in hormonal contraceptives users.   Methods: A total of 160 consenting participants made of 80 subjects on different forms of hormonal contraceptives and 80 controls on non hormonal IUCD were recruited into this study. A structured questionnaire was administered to obtain information required; blood samples were collected from each of the participant into appropriate containers using standard methods. Fibrinogen assay was done using the STAGO STart®4 coagulation analyzer while D-dimer was measured using ZYMUTEST DDIMER ELISA kit (HYPHEN BioMed). The results were analyzed using SPSS version 17.0 software. Statistical significance was based on p value < 0.05. Results. The mean fibrinogen levels of the study group and controls were 387.10±62.52 and 276.85±52.70 respectively, (reference range 180-400ng/ml). The mean D dimer concentrations of the study group was markedly elevated 813.36±212.35 while that of the controls was 257.04±108.33 (reference range <400). Both analytes showed a statistically significant difference between the study group and control (P<0.05). None of the client on COCP has elevated D dimer level. Conclusion: The significant increase in the procoagulant protein- fibrinogen and corresponding increase in fibrinolytic activity as demonstrated by elevated Ddimer level reflect a balance between fibrin formation and degradation hence minimizing the VTE risk. This balance is less prominent with use of COCP and can be attributed to the oestrogen component. 

Author Biographies

Sani Bako Abubakar, Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria
Department of Haematology and Blood Transfusion
Aisha Indo Mamman, Transfusion Ahmadu Bello University Teaching Hospital Zaria, Nigeria
Department of Haematology and Blood
Muhammad Adogie Abdul, Ahmadu Bello University Teaching Hospital Zaria, Nigeria
Department of Obstetrics and Gynaecology
Muhammad Zainu Sabitu, Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria
Department of  Medical Microbiology


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Original Article