Study Of Clinico-Histopathological Correlation of Seborrheic Keratosis
Keywords:
dermatosis papulosanigra, histology, Seborrheic keratosis
Abstract
Background: Seborrheic keratosis (SK) is one of the mostcommon epidermal tumors of the skin. However, only a few large-scale clinic-histopathological investigations have been conducted on SK or on the possible correlation be-tween histopathological SK subtype and location. The aim of this study was to analyze the clinical and histopathological features of a relatively large number of cases of diagnosed SK. Methods: Seventy five (75) pathology slides of skin tissue from patients with clinically diagnosed SK and 67 cases of biopsy-proven SK were analyzed. The biopsy-proven cases of SK were assessed for histopathological subclassification. The demographic, clinical, and histopathological data of the patients were collected for analysis of associated factors. Result: Seborrheic keratosis commonly present in old age most common age group is 60-70 yr. It affects male and female equally (M:F-1.12:1).Most common etiology in our study is sun exposure. In our study upper extremities are most commonly involved.Among histologically proven 67 cases most common histological type in our study is clinical seborrheic keratosis(CSK) (68.65%) followed by stucco keratosis (23.88%). Among common seborrheic keratosis hyperkeratotic type (31.34%) is most common followed by melanoacanthoma (19.40%).Histopathologically proven cases of seborrheic keratosis shows significant presence histopathological features like hyperkeratosis (69.33%), acanthosis (66.66%) and papillomatosis(60%). Hyperpigmentation is also present in significant number of cases (34.66%). Conclusion: SK appear to be more common in old-age, with equal sex distribution, predominantly affecting the upper extremities, head, and neck. Sun exposure was the most common etiology. The most frequent SK histopathological sub-type found in this study was the clinical seborrheic keratosis followed by stucco keratosis. In clinical seborrheic keratosis most common variant was hyperkeratotic type followed by melanoacanthoma. Most of the characteristics of SK are in accordance with the literature published.References
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2. Pending Elder DE. Lever's histopathology of the skin. Lippincott Williams & Wilkins; 2014 Sep 9.
3. Yeatman JM, Kilkenny M, Marks R. The prevalence of seborrhoeic keratoses in an Australian population: does exposure to sunlight play a part in their frequency?. British Journal of Dermatology. 1997 Sep;137(3):411-4.
4. Kwon OS, Hwang EJ, Bae JH, Park HE, Lee JC, Youn JI, Chung JH. Seborrheic keratosis in the Korean males: causative role of sunlight. Photodermatology, photoimmunology & photomedicine. 2003 Apr;19(2):73-80.
5. Kim HY, Kim HS, Cho EB, Park EJ, Kim KH, Kim KJ. A clinicohistopathological study on the lesion resembling seborrheic keratoses of the face. Korean Journal of Dermatology. 2013 Jul 1;51(7):494-500.
6. Jeong YI, Lee WJ, Bak H, Oh SH, Jung HJ, Chang SE, Choi JH. Detection of human papilloma virus DNA in seborrheic keratosis of Korean skin. Annals of Dermatology. 2007 Sep 1;19(3):99-105.
7. Marks R, Jolley D, McCormack C, Dorevitch AP. Who removes pigmented skin lesions?: A study of the ratio of melanoma to other benign pigmented tumors removed by different categories of physicians in Australia in 1989 and 1994. Journal of the American Academy of Dermatology. 1997 May 1;36(5):721-6.
8. Roh NK, Hahn HJ, Lee YW, Choe YB, Ahn KJ. Clinical and histopathological investigation of seborrheic keratosis. Annals of dermatology. 2016 Apr 1;28(2):152-8.
9. Rajesh G, Thappa DM, Jaisankar TJ, Chandrashekar L. Spectrum of seborrheic keratoses in south Indians: A clinical and dermoscopic study. Indian Journal of Dermatology, Venereology, and Leprology. 2011 Jul 1;77(4):483.
10. Alapatt GF, Sukumar D, Bhat MR. A clinicopathological and dermoscopic correlation of seborrheic keratosis. Indian journal of dermatology. 2016 Nov;61(6):622.
11. Zhang RZ, Zhu WY. Seborrheic keratoses in five elderly patients: An appearance of raindrops and streams. Indian journal of dermatology. 2011 Jul;56(4):432.
12. Park S, Park H, Cho K. Clinical and histopathologic study of seborrheic keratosis. Korean Journal of Dermatology. 2011 Jan 1;49(1):12-9.
13. Roh NK, Hahn HJ, Lee YW, Choe YB, Ahn KJ. Clinical and histopathological investigation of seborrheic keratosis. Annals of dermatology. 2016 Apr 1;28(2):152-8.
14. Thomas VD. Benign epithelial tumors, hamartomas, and hyperplasias. Fitzpatrick's dermatology in general medicine. 2008.
15. Elgart GW. Seborrheic keratoses, solar lentigines, and lichenoid keratoses: dermatoscopic features and correlation to histology and clinical signs. Dermatologic clinics. 2001 Apr 1;19(2):347-57.
16. Moskaluk CA, Merino MJ, Danforth DN, Medeiros LJ. Low-grade angiosarcoma of the skin of the breast: a complication of lumpectomy and radiation therapy for breast carcinoma. Human pathology. 1992 Jun 1;23(6):710-4.
17. Engel A, Johnson ML, Haynes SG. Health effects of sunlight exposure in the United States: results from the first National Health and Nutrition Examination Survey, 1971-1974. Archives of dermatology. 1988 Jan 1;124(1):72-9.
2. Pending Elder DE. Lever's histopathology of the skin. Lippincott Williams & Wilkins; 2014 Sep 9.
3. Yeatman JM, Kilkenny M, Marks R. The prevalence of seborrhoeic keratoses in an Australian population: does exposure to sunlight play a part in their frequency?. British Journal of Dermatology. 1997 Sep;137(3):411-4.
4. Kwon OS, Hwang EJ, Bae JH, Park HE, Lee JC, Youn JI, Chung JH. Seborrheic keratosis in the Korean males: causative role of sunlight. Photodermatology, photoimmunology & photomedicine. 2003 Apr;19(2):73-80.
5. Kim HY, Kim HS, Cho EB, Park EJ, Kim KH, Kim KJ. A clinicohistopathological study on the lesion resembling seborrheic keratoses of the face. Korean Journal of Dermatology. 2013 Jul 1;51(7):494-500.
6. Jeong YI, Lee WJ, Bak H, Oh SH, Jung HJ, Chang SE, Choi JH. Detection of human papilloma virus DNA in seborrheic keratosis of Korean skin. Annals of Dermatology. 2007 Sep 1;19(3):99-105.
7. Marks R, Jolley D, McCormack C, Dorevitch AP. Who removes pigmented skin lesions?: A study of the ratio of melanoma to other benign pigmented tumors removed by different categories of physicians in Australia in 1989 and 1994. Journal of the American Academy of Dermatology. 1997 May 1;36(5):721-6.
8. Roh NK, Hahn HJ, Lee YW, Choe YB, Ahn KJ. Clinical and histopathological investigation of seborrheic keratosis. Annals of dermatology. 2016 Apr 1;28(2):152-8.
9. Rajesh G, Thappa DM, Jaisankar TJ, Chandrashekar L. Spectrum of seborrheic keratoses in south Indians: A clinical and dermoscopic study. Indian Journal of Dermatology, Venereology, and Leprology. 2011 Jul 1;77(4):483.
10. Alapatt GF, Sukumar D, Bhat MR. A clinicopathological and dermoscopic correlation of seborrheic keratosis. Indian journal of dermatology. 2016 Nov;61(6):622.
11. Zhang RZ, Zhu WY. Seborrheic keratoses in five elderly patients: An appearance of raindrops and streams. Indian journal of dermatology. 2011 Jul;56(4):432.
12. Park S, Park H, Cho K. Clinical and histopathologic study of seborrheic keratosis. Korean Journal of Dermatology. 2011 Jan 1;49(1):12-9.
13. Roh NK, Hahn HJ, Lee YW, Choe YB, Ahn KJ. Clinical and histopathological investigation of seborrheic keratosis. Annals of dermatology. 2016 Apr 1;28(2):152-8.
14. Thomas VD. Benign epithelial tumors, hamartomas, and hyperplasias. Fitzpatrick's dermatology in general medicine. 2008.
15. Elgart GW. Seborrheic keratoses, solar lentigines, and lichenoid keratoses: dermatoscopic features and correlation to histology and clinical signs. Dermatologic clinics. 2001 Apr 1;19(2):347-57.
16. Moskaluk CA, Merino MJ, Danforth DN, Medeiros LJ. Low-grade angiosarcoma of the skin of the breast: a complication of lumpectomy and radiation therapy for breast carcinoma. Human pathology. 1992 Jun 1;23(6):710-4.
17. Engel A, Johnson ML, Haynes SG. Health effects of sunlight exposure in the United States: results from the first National Health and Nutrition Examination Survey, 1971-1974. Archives of dermatology. 1988 Jan 1;124(1):72-9.
Published
2019-11-26
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