Relationship of Mean Platelet Volume and HbA1c in Predicting the Level of Diabetes Control in Type 2 Diabetes Mellitus
Keywords:
HbA1c, Diabetes Mellitus, Mean platelet volume, Platelet parameters, Predicting
Abstract
Background: MPV is an indicator of platelet size and MPV is increased in DM as compared to non-diabetics, more so in presence of complications. There are few studies evaluating the association between MPV and HbA1c and its role in predicting glycaemic control with conflicting results. The present study was planned to determine the relationship between MPV and HbA1c in predicting the level of diabetes control in type 2 DM. Methodology: Cross sectional observational study including 100 consecutive cases of type 2 DM aged between 30 to 60 years. Mean platelet volume (MPV), platelet distribution width (PDW) and platelet count were obtained from fully automated haematology analyser Sysmex KX-21. Glycosylated haemoglobin (HbA1c) was analysed by automated haemoglobin analyser. Results: The mean age among 100 type 2 DM cases was 49.58 ± 14.49 years. The mean value of MPV and HbA1c was 10.25±0.90fl and 5.66± 1.17% respectively. There was no significant correlation found between MPV and HbA1c (r=0.110, p=0.275). Similarly, there were no significant association between MPV and three levels of glycaemic control. Conclusion: MPV is not a reliable marker for determining glycaemic control in type 2 DM.References
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16. Hekimsoy Z, Payzin B, Ornek T, Kandoğan G. Mean platelet volume in type 2 diabetic patients. J Diabetes Complications 2004;18:173-6.
17. Sharpe PC, Trinick T. Mean platelet volume in diabetes mellitus. QJ Med. 1993;86:739-42.
18. Tschoepe D, Roesen P, Esser J, Schwippert B, Nieuwenhuis HK, Kehrel B, et al. Large platelets circulate in an activated state in diabetes mellitus. Semin Thromb Hemost 1991; 17:433-38.
2. Vinik AI, Erbas T, Park TS, Nolan R and Pit¬tenger GL. Platelet dysfunction in type 2 diabe¬tes. Diabetes Care 2001; 24:1476-85.
3. Sherwani SI , Khan HA, Ekhzaimy A, Masood A, and Sakharkar MK. Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients. Biomark Insights 2016; 11: 95–104.
4. Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HKM, et al. Mean Platelet Volume in Type 2 Diabetes Mellitus. Journal of Laboratory Physicians 2012;4:5-9.
5. Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K, et al. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Haematology 2011; 16:86-9.
6. Jaman S, Rezwan S, Islam SAR, Husna AU, Sayeed MA. Association of Mean Platelet Volume and Platelet Distribution Width with Hba1c. Journal of Endocrinol Diab 2017;4:1-6.
7. Kumar A, Goel MK, Jain RB, Khanna P, Chaudhary V. India towards diabetes control: Key issues. Australas Med J 2013;6:524-31.
8. Ulutas KT, Dokuyucu R, Sefil F, Yengil E, Sumbul AT, Rizaoglu H et al. Evalution of MPV in patients with type 2 diabetes mellitus and blood glucose regulation: A marker of atherosclerosis. Int J Clin Exp Med. 2014;7:955-61.
9. Schneider, David J. Factors Contributing to Increased Platelet Reactivity in People with Diabetes. Diabetes Care 2009;32:525–27.
10. Jabeen F, Fawwad A, Rizvi HA, Alvi F. Role of platelet indices, glycaemic control and hs-CRP in pathogenesis of vascular complications in type-2 diabetic patients. Pak J Med Sci. 2013;29:152-6.
11. Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004;15:475-8.
12. Demirtunc R, Duman D, Basar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Complications 2009;23:89–94.
13. Dubey I, Gaur BS, Singh R. A study to find correlation of platelet indices with HbA1c in diabetic patients with absence/presence of vascular complications. Int J Res Med Sci 2017;5:1042-47.
14. Unubol M, Ayhan M, Güney E. The relationship between mean platelet volume with micro albuminuria and glycaemic control in patients with type II diabetes mellitus. Platelets 2012; 23:475–80.
15. Bhanukumar M, Ramaswamy PKH, Peddi NK, Menon VB. Mean platelet volume and platelet distribution width as markers of vascular thrombosis in type 2 diabetes mellitus. Journal of Postgraduate Medicine, Education and Research 2016;50:127-31.
16. Hekimsoy Z, Payzin B, Ornek T, Kandoğan G. Mean platelet volume in type 2 diabetic patients. J Diabetes Complications 2004;18:173-6.
17. Sharpe PC, Trinick T. Mean platelet volume in diabetes mellitus. QJ Med. 1993;86:739-42.
18. Tschoepe D, Roesen P, Esser J, Schwippert B, Nieuwenhuis HK, Kehrel B, et al. Large platelets circulate in an activated state in diabetes mellitus. Semin Thromb Hemost 1991; 17:433-38.
Published
2020-04-02
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