Clinicopathological Study of Salivary Gland Tumors

  • Somnath Sangram Khedkar BJGMC, Pune, Maharashtra, India
  • Anup Pravin Bhandari BJGMC, Pune, Maharashtra, India
  • Nilesh Pradip Shirgaonkar RCSMGMC, Kolhapur, Maharshtra, India
Keywords: Benign, Malignant, Pleomorphic Adenoma, Mucoepidermoid Carcinoma

Abstract

Background: Salivary gland tumors represent the most complex and diverse group of tumors, diagnosis and management of which is complicated by their relative infrequency, the limited amount of pretreatment information available and the wide range of biologic behavior seen with the different pathologic lesions. However, there are no reliable criteria to differentiate, on clinical grounds the benign from the malignant lesions and morphologic evaluation is necessary. Hence, the present study is undertaken to study the spectrum of benign and malignant tumors of salivary gland with emphasis on histopathological features. Methods: Prospective and retrospective study (2012 to 2016) comprised of Fine needle aspiration cytology (FNAC), histopathology specimens and slides received in our Department of Pathology during period of 5 years. In each patient age, sex, site and relevant clinical details were recorded in a proforma. FNAC is performed whenever possible followed by histopathological examination as gold standard for diagnosis. Results were analysed in tabular format and Sensitivity, Specificity and Diagnostic accuracy were calculated according to standard formulas. Result: During the study period of five years 60 salivary gland neoplasms were studied out of which 40 were benign, most common being pleomorphic adenoma. Most common malignant tumor was mucoepidermoid carcinoma. Mean age of presentation was 41 years. Histocytological correlation was obtained in 40 cases. Conclusion: Salivary gland tumors are relatively uncommon, and exhibit a wide variety of microscopic appearances, even within one particular lesion, and this has caused considerable problems in categorization and diagnosis. Accurate diagnosis is essential as salivary gland neoplasms have diverse clinical and prognostic outcomes.

Author Biographies

Somnath Sangram Khedkar, BJGMC, Pune, Maharashtra, India
Department of Pathology
Anup Pravin Bhandari, BJGMC, Pune, Maharashtra, India
Department of Pathology
Nilesh Pradip Shirgaonkar, RCSMGMC, Kolhapur, Maharshtra, India
Department of Pathology

References

1. Chan JK, Cheuk W. Salivary gland tumors. Chapter 7, In : Fletcher CDM, editor. Diagnostic histopathology of tumors. 3rd ed. china: Churchill Livingstone Elsevier; 2007. p. 239-325.
2. Barnes L, Eveson JW, Reuichart P, Sidrawsky D. WHO classification of tumors. Pathology and Genetics of Head and Neck Tumors : Lyon : IARC Press; 2005. p. 209-281.
3. Lingel MW, Kumar V. Head and Neck. Chapter 16, In : Kumar V, Abbas AK, Fausto N, editors. Robbins and Cotran Pathologic basis of disease. 7th ed, Philadelphia : Saunders; 2004. P. 790-91.
4. Sharkey FE. Clinicopathologic study of 366 salivary gland tumors. Am J Clin Pathol 1977;67:272-278.
5. Dardick I. Histogenesis and morphogenesis of salivary gland neoplasms. Chapter 7. In : Ellis GL, Auclair PL, Gnepp DR, editors. Surgical pathology of the salivary glands. Vol. 25, Philadelphia : WB Saunders Company; 1991. P.108-129.
6. Cheuk W, Chan JKC. Advances in salivary gland pathology. Histopathology 2007;51: 1-20.
7. Araya J, Martinez R, Niklander S, Marshall M, Esguep A. Incidence and prevalence of salivary gland tumours in Valparaiso, Chile. Med Oral Patol Oral Cir Bucal. 2015;20(5):e532–e539. Published 2015 Sep 1. doi:10.4317/medoral.20337
8. de Oliveira FA, Duarte EC, Taveira CT, Maximo AA, de Aquino EC, Alencar RC. Salivary gland tumor: a review of 599 cases in a Brazilian population. Head and neck pathology. 2009;3:271–5.
9. Tian Z, Li L, Wang L, Hu Y, Li J. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. International journal of oral and maxillofacial surgery. 2010;39:235–42.
10. Lukši? I, Virag M, Manojlovi? S, Macan D. Salivary gland tumours: 25 years of experience from a single institution in Croatia. Journal of cranio-maxillo-facial surgery. 2012;40:e75–81.Nagaon, T., Gaffey, T.A., Kay, P.A., Minato, H., Seriawa, H. and Lewis, J. E. (2004), Polymorphous low-grade adenocarcinoma of the major salivary glands: report of three cases in an unusual location. Histopathology, 40: 164-171.
11. Solange SL, Andrea FS, Rivadaxia FB, Roseana DA. Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases. Rev Bras Otorhinolaryngo 2005; 71(3): 335-340.
12. Gupta SK, Sengupta P, Sarkar SK. Primary tumors of salivary glands. J Ind Med Assoc 1975;65(10):277-280.
13. Thomas KM, Hutt MSR, Borgstein J. Salivary gland tumors in Malawi.Cancer 1980;46:2328-2334.
14. Davies JNP, Doge OG, Burkitt DP. Salivary gland tumors in Uganda.Cancer 1964;17:1310-1322.
15. Cheuk W, Chan JKC. Advances in salivary gland pathology. Histopathology 2007;51: 1-20.
16. Ersöz, Canan & Uguz, Aysun & Tuncer, Ülkü & Soylu, Levent & Kiroglu, Mete. (2004). Fine needle aspiration cytology of the salivary glands: a twelve years' experience. Aegean Pathol J. 1.
17. Nagaon, T., Gaffey, T.A., Kay, P.A., Minato, H., Seriawa, H. and Lewis, J. E. (2004), Polymorphous low-grade adenocarcinoma of the major salivary glands: report of three cases in an unusual location. Histopathology, 40: 164-171.
18. Seifert G, Schulz J. Adenocarcinoma of the salivary glands. The pathohistology and sub-classification of 77 cases. HNO 1985; 33(10) :433-442.
Published
2020-06-06
Section
Original Article