Histopathological Study of Parotid Gland Tumors
Keywords:
Parotid Tumors, Pleomorphic adenoma, Mucoepidermoid carcinoma, histopathological examination
Abstract
Background: Parotid tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. There are no reliable criterias to differentiate clinically benign from malignant lesions, so morphological evaluation is necessary. Hence, present study is undertaken to study spectrum of various histomorphological features. To study prevalence, age, sex distribution, histomorphological aspects and to differentiate benign from malignant parotid tumors. Methods: A total of 60 specimens of Parotid tumors analyzed from January 2012 to December 2014 from department of pathology, B.J Medical College, Ahmedabad. Specimens were fixed in formalin and sections were taken, processed and embedded in paraffin. The paraffin blocks were cut, slides made and stained with hematoxylin and eosin and examined. The tumors were classified according to (WHO) histological typing. The collected data were analyzed statistically. Result: Prevalence of parotid tumors was 0.47 %. All the patients presented with mass. Most of benign neoplasms occurred in 3rd and 4th decade, while malignant neoplasms more common in 5th decade. Males were more commonly affected. Pleomorphic adenoma was the commonest benign tumor and Mucoepidermoid carcinoma was the commonest malignant tumor. Conclusion: Although rare, parotid tumors are of importance because they show striking range of morphologic diversity between different tumor types and sometimes within an individual tumor mass. So, accurate diagnosis is essential which can be accomplished by histopathological examination.References
1.Chapter in a book: Juan Rosai. Chapter 12 In : Rosai and Ackerman’s Surgical Pathology, Tenth edition, Volume I, Major and Minor Salivary Gland; Mosby; Elseveir; 2011 : 817-842.
2. Chapter in book: Stephen Sternberg. Chapter- 20 In : Diagnostic Surgical Pathology, Sixth Edition, Volume I, Salivary gland; Lippincott Williams and Wilkins; Philadelphia; 2015: 906-946.
3. Nagao I, Sugano I, Ishida Y, Asoh A, Munakata S, Yamazaki K, Konno A, Iwaya K, Shimizu I, Serizawa H, Ebihara Y. Hybrid Carcinomas of the Salivary Glands: Report of Nine Cases with a Clinicopathologic, Immunohistochernical and p53 Gene Alteration Analysis. Mod Pathol 2002 Jul: 1 5(7):724-33.
4. Nagao T, Gaffey TA, Serizawa H, Suganol, Ishida Y, Yarnazaki K, Tokashiki R, Yoshida I. Minato H, Kay PA, Lewis JE. Dedifferentiated Adenoid Cystic Carcinoma: A Clinicopathologic Study of 6 Cases. Mod Pathol 2003: 16(12): 1265—1272.
5. Victor Shing Howe To, Jimmy Yu Wai Chan, Raymond K. Y. Tsang, and William I. Wei. Review of Salivary Gland Neoplasms. ISRN Otolaryngology Volume 2012, Article ID 872982, 6 Pages.
6. Barnes L, Eveson SW, Reuichart P, Sidrawskv D. WHO classification of tumors. Pathology and Genetics of Head and Neck Tumors: Lyon: IARC Press 2005, p. 209-281.
7. ONS Cancer Registration Statistics, England, 2013.
8. Amos B, Philip WM, William MC. Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from Northern California and comparison to reports from other parts of the world. J Oral Pathol Med 2007:36(4): 207-214.
9. Fonseca FP, Carvalho MV, de Almeida OP, Rangel AL, Takizawa MC, Bueno AG, et al. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral surgery, oral medicine, oral pathology and oral radiology. 2012;114:230-9.
10. Ito FA, Ito K, Vargas PA, de Almeida OP, Lopes MA. Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. International journal of oral and maxillofacial surgery. 2005;34:533-6.
11. Shishegar M, Ashraf MJ, Azarpira N, Khademi B, Hashemi B, Ashrafi A. Salivary gland tumors in maxillofacial region: a retrospective study of 130 cases in a southern Iranian population. Pathology research international. 2011;2011:934350.
12. Tian Z, Li L, Wang L, Hu Y, Li J. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 2010 Mar;39(3):235-42.
13. Ochicha Ochicha, Sani Malami, Aminu Mohammed, Akinfenwa Atanda. A histopathologic study of salivary gland tumors in Kano, northern Nigeria. IJPM. 2009; 52 : 473 - 476.
14. Shoeman BJ and Clifford SD. The incidence of malignancy in salivary gland neoplasms.South Afr J Surg.2007; 45(4):134-135.
15. Shrestha S, Pandey G et al. Histopathological Pattern of Salivary Gland tumors. Journal of pathology of Nepal.2014; 20 : 520-524.
16. Deepika S, Rohit S et al. Salivary gland neoplasms: An analysis of 74 cases. J Maxillofacial Oral Surg 8(2): 164-166.
17.Audrey R, Cecile B. Atlas of Genetics and Cytogenetics in Oncology and Hematology. 2009-2010. 5328.
18. Girresh V A. A Clinicopathological Study Of Salivary Gland Tumors. Journal of Evolution of medical and Dental sciences.Vol. 2, 2013; 972-9731.
19. Mohammad A M, Zahid S, Abbas Z and Shoukat M, Morphological pattern of Parotid tumors. Journal of the College of Physicians and Surgeons 2008;18 (5):274-277.
2. Chapter in book: Stephen Sternberg. Chapter- 20 In : Diagnostic Surgical Pathology, Sixth Edition, Volume I, Salivary gland; Lippincott Williams and Wilkins; Philadelphia; 2015: 906-946.
3. Nagao I, Sugano I, Ishida Y, Asoh A, Munakata S, Yamazaki K, Konno A, Iwaya K, Shimizu I, Serizawa H, Ebihara Y. Hybrid Carcinomas of the Salivary Glands: Report of Nine Cases with a Clinicopathologic, Immunohistochernical and p53 Gene Alteration Analysis. Mod Pathol 2002 Jul: 1 5(7):724-33.
4. Nagao T, Gaffey TA, Serizawa H, Suganol, Ishida Y, Yarnazaki K, Tokashiki R, Yoshida I. Minato H, Kay PA, Lewis JE. Dedifferentiated Adenoid Cystic Carcinoma: A Clinicopathologic Study of 6 Cases. Mod Pathol 2003: 16(12): 1265—1272.
5. Victor Shing Howe To, Jimmy Yu Wai Chan, Raymond K. Y. Tsang, and William I. Wei. Review of Salivary Gland Neoplasms. ISRN Otolaryngology Volume 2012, Article ID 872982, 6 Pages.
6. Barnes L, Eveson SW, Reuichart P, Sidrawskv D. WHO classification of tumors. Pathology and Genetics of Head and Neck Tumors: Lyon: IARC Press 2005, p. 209-281.
7. ONS Cancer Registration Statistics, England, 2013.
8. Amos B, Philip WM, William MC. Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from Northern California and comparison to reports from other parts of the world. J Oral Pathol Med 2007:36(4): 207-214.
9. Fonseca FP, Carvalho MV, de Almeida OP, Rangel AL, Takizawa MC, Bueno AG, et al. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral surgery, oral medicine, oral pathology and oral radiology. 2012;114:230-9.
10. Ito FA, Ito K, Vargas PA, de Almeida OP, Lopes MA. Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. International journal of oral and maxillofacial surgery. 2005;34:533-6.
11. Shishegar M, Ashraf MJ, Azarpira N, Khademi B, Hashemi B, Ashrafi A. Salivary gland tumors in maxillofacial region: a retrospective study of 130 cases in a southern Iranian population. Pathology research international. 2011;2011:934350.
12. Tian Z, Li L, Wang L, Hu Y, Li J. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 2010 Mar;39(3):235-42.
13. Ochicha Ochicha, Sani Malami, Aminu Mohammed, Akinfenwa Atanda. A histopathologic study of salivary gland tumors in Kano, northern Nigeria. IJPM. 2009; 52 : 473 - 476.
14. Shoeman BJ and Clifford SD. The incidence of malignancy in salivary gland neoplasms.South Afr J Surg.2007; 45(4):134-135.
15. Shrestha S, Pandey G et al. Histopathological Pattern of Salivary Gland tumors. Journal of pathology of Nepal.2014; 20 : 520-524.
16. Deepika S, Rohit S et al. Salivary gland neoplasms: An analysis of 74 cases. J Maxillofacial Oral Surg 8(2): 164-166.
17.Audrey R, Cecile B. Atlas of Genetics and Cytogenetics in Oncology and Hematology. 2009-2010. 5328.
18. Girresh V A. A Clinicopathological Study Of Salivary Gland Tumors. Journal of Evolution of medical and Dental sciences.Vol. 2, 2013; 972-9731.
19. Mohammad A M, Zahid S, Abbas Z and Shoukat M, Morphological pattern of Parotid tumors. Journal of the College of Physicians and Surgeons 2008;18 (5):274-277.
Published
2020-04-29
Issue
Section
Original Article
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
