Cytomorphological Analysis of Neoplastic Lesions of Neck Node with Special Reference to Lymphomas
Keywords:
Lymph Node, Neoplasms, FNAC, Histopathology, Immunohistochemistry
Abstract
BACKGROUND: Neoplastic lesions of lymph node in cervical region pose a diagnostic delima and very often cytological diagnosis proves invaluable. An early diagnosis of the lesions is essential for proper management. To assess the frequency distribution and cytological analysis of various neoplastic lesions of lymph node with special reference to the lymphoma. MATERIAL AND METHODS: this is a cross-sectional study which provides analysis of 164 neoplastic lesions of lymph node out of 758 lymph node aspirate. Cytomorphological pattern and cellular detail are reviewed carefully and diagnosis were made. Histopathological and immunohistochemical correlation done wherever needed. RESULTS: Out of 164 neoplasms 86.59% secondary neoplasms(61.27% SCC, 19.72% Adenocarcinoma,15.49% poorly differentiated carcinoma,0.70% undifferentiated carcinoma, 0.70% mucoepidermoid carcinoma, 0.70% papillary thyroid carcinoma,1.41% leukemic deposit),12.2% lymphoid neoplasms. M:F = 1.2:1. Diagnostic accuracy was calculated as 98.67%, and false positive rate 1.3% CONCLUSION: fine needle aspiration cytology is invaluable in rapid diagnosis of lymph node neoplasms of cervical region however histological confirmation and immunohistochemical analysis is mandatory in certain tumors specially lymphomas, poorly and undifferentiated carcinoma for accurate diagnosis and proper management.References
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18) Patra AK, Banda BK, Mohapatra, Panda AK. Diagnosis of lymphadenopathy by fine needle aspiration cytology. Indian J pathol Microbiol 1983; 26: 273-278.
19) Verma K, Mandal S, Kapik. Cystic change in lymph nodes with metastatic squamous cell carcinoma. Acta cytologica 1995; 39:478-480.
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21) Russel J, Skinner J, Orell S, Seshardi R: Fine needle aspiration cytology in management of lymphomas. Aus NZ J Med 1983, 13: 365-368.
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2) Orell SR, Sterrett GF, Whitaker D. Fine needle aspiration cytology 4th edition. New Delhi: Elsevier Health Sciences; 2005.
3) Steel BL, Schwartz Mary, Ramzy Ibrahim. Fine needle aspiration biopsy in diagnosis of lymphadenopathy in 1103 patients. Acta cytologica 1995; 39 (1): 76-81
4) I Bagwan, S Kane, R Chinoy, Cytologic evaluation of the enlarged neck node: FNAC utility in Metastatic neck disease. The internet journal of pathology. 2006 vol 6 number 2.
5) U Jindal, K. Singh, A Baghla, A Kochhar. Spectrum of head and neck swellings in the rural population of India based on fine needle aspiration findings. The internal journal of Head and Neck surgery 2012 volume 5 number 2.
6) Gunvanti B R, Pragnesh P. Fine needle aspiration cytology of swellings of head and neck region. Indian Journal of Medical science, vol.66, no. 3 and 4, March and April 2012
7) Maniyar AU, Patil HL and Parmar BH. Study of cytodiagnosis of head and neck neoplastic lesions and comparison with histopathology Research and Reviews: Journal of Medical and health Sciences. vol.21 issue 21 April-June, 2013.
8) Rastogi T, Devesa S, Mangtani P, Mathew A, Cooper N, Kao R et al. Cancer incidence rates among South Asian in four geographic regions: India, Singapore, UK and US. Int. J. Epidemiol 2008; 37: 147-60.
9) Raju G, Kakkar PK, Das DK, Dhingra PL, Bhambani S. Role of aspiration biopsy in head and neck tumors. J. Otolaryngol Otol 1988; 102: 248-251.
10) Ustum M, Risberg B, Davidson B cystic change in metastatic lymph nodes. Diagnostic cytopathology 2002; 27: 387-392.
11) Kusum V, Mandal S, Kapila K. cystic change in lymph nodes with metastatic squomous cell carcinoma. Acta cytol 1995; 39:478-480.
12) EI Hag IA, Chiedozi LC, AI Revees FA. Fine needle aspiration cytology of head and neck masses-seven year experience in a secondary care hospital. Acta Cytologica 2003; 47 (3) : 387-392.
13) Hirachand S, Lakhey M, Akhter P, Thapa B. Evaluation of fine needle aspiration cytology of lymph node in Kathmandu Medical College, teaching hospital, Kathmandu Univ. Med J 2009; 7:139-42.
14) Hoft S, Muhle C, Brenner W, Sprenger E, Maune S. Fine needle aspiration cytology of the sentinal lymph node in head and neck cancer. J Nucl Med 2002; 43: 1585-90.
15) Sankalap T, MRCS, Riad S, James IB, MBBS, Samit K G, MRCS, Jonathan Sheard, MD, FRC path, Terry M. Jones, FRCS (ORL-HNS) MD. Fine needle aspiration cytology in a Regional head and neck cancer centre: comparison with a systematic review and Meta-analysis. Wiley Inter science (www.interscience.wiley.com) DOI: 10. 1002/hed. 20849.
16) Shaha A, Webber C, Marti J. Fine needle aspiration in diagnosis of cervical lymphadenopathy. Am J surg. 1986; 152: 420-423.
17) Tippu I, Ram KG, Arvind Khajuria. Role of FNAC in diagnosis of non-thyroidal head and neck lesions. www.jkscience.org.vol14 no. 1, January-March 2012.
18) Patra AK, Banda BK, Mohapatra, Panda AK. Diagnosis of lymphadenopathy by fine needle aspiration cytology. Indian J pathol Microbiol 1983; 26: 273-278.
19) Verma K, Mandal S, Kapik. Cystic change in lymph nodes with metastatic squamous cell carcinoma. Acta cytologica 1995; 39:478-480.
20) Katz RL Caray NP: FNA lymphoproliferative diseases: Myths and legends. Diag. Cytopathol 1995, 12:99-100.
21) Russel J, Skinner J, Orell S, Seshardi R: Fine needle aspiration cytology in management of lymphomas. Aus NZ J Med 1983, 13: 365-368.
22) Saikia UN, Dey P, Saikia B, Das A: Fine needle aspiration biopsy in diagnosis of follicular lymphoma. A cytomorphologic and immunohistochemical analysis. Diagn. Cytopathol 2002, 26:251-256.
Published
2020-07-03
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