A Comparison Between Cytological and Histopathological Grading System in Cases of Breast Malignancy
Keywords:
FNAC, breast cancer, Cytopathology, Histopathology
Abstract
Background Treatment of breast malignancies depends on its types and grades. Classification of breast lesion is usually based on the histological appearance of tissue in the tumor. Like histopathology, the diagnostic cytology is also a useful tool for the oncologist and surgeons. It is possible to grade breast cancer on fine-needle aspirates. Material and methods: A prospective study of FNAC of breast lesions was carried out along with its histopathological correlation. Malignant breast lesion diagnosed on FNAC were graded using Robinson's grading system and correlated with Elstons modified Bloom Richardson histological grading system. Results: The sensitivity, specificity and accuracy of the fine needle aspiration cytology to diagnose breast malignancy were 84.84%, 100.00% and 93.75% respectively. Out of 17 cases of Robinson gradeing on FNAC, 12(70.59%) cases were well correlated with Bloom-Richardson histological grade. Conclusion: Cytological grading is simple, less time consuming and with rare exceptions correlates precisely with the histological grade. It helps to know prognostic evaluation of breast carcinoma along with diagnosis.References
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2. Pal S, Gupta ML. Correlation between cytological and histological grading of breast cancer and its role in prognosis. J Cytol 2016;33:182-6
3. Khan N, Afroz N, Rana F, Khan MA. Role of cytologic grading in prognostication of invasive breast carcinoma. J Cytol. 2009;26:65–8.
4. Robinson IA, McKee G, Nicholson A, D’Arey J, Jackson PA, Cook MG, et al. Prognostic value of cytological grading of fine-needle aspirates from breast carcinomas. Lancet 1994;343:947-49.
5. Ohri A, Jetly D, Shukla K, Bansal R. Cytological grading of breast neoplasia and its correlation with histological grading. Indian J Pathol Microbiol 2006;49:208-13.
6. Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer : experience from a large study with long-term follow-up. Histopathology 1991;19(5):403-410.
7. Robles-Frias A, Gonzalez-Campora R, Martinez-Parra D, Robles-Frias M, Vazquez-Cerezuda T, Otal-Salaverri C, et al. Robinson cytologic grading of invasive ductal breast carcinoma. Correlation with histologic grading and regional lymph node metastasis. Acta Cytol 2005;49:149-53
8. Chhabra S, Singh PK, Agarwal A, Bhagolival A, Singh SN. Cytological grading of breast carcinoma – A multivariate regression analysis. Journal of Cytology 2005;22:62-5.
9. Pandit AA, Parekh HJ. Cytologic grading of breast carcinoma. Comparison of four grading systems. Journal of Cytology 2000;17:39-44.
10. Mahajan NA, Bhale CP, Mulay SS. Fine needle aspiration cytology of breast lesions and correlation with histopathology- A 2 year study. Int J Health Sci & Res 2013;3(2):55-65
11. Bukhari MH, Arshad M, Jamal S, Niazia S, Bashir S, Bakhshi IM et al. Use of fine needle aspiration cytology in the evaluation of breast lumps. Pathology Research International. 2011;01:1-10.
12. Singh A, Haritwal A and Murali BM. Pattern Of breast Lumps and Diagnostic Accuracy Of Fine Needle Aspiration Cytology; A Hospital Based Study from Pondicherry, India. The Internet Journal of Pathology.2011;11(2):1-14.
13. Phukan JP, Sinha A, Deka JP. Cytological grading of breast carcinoma on fine needle aspirates and its relation with histological grading. South Asian J Cancer 2015;4:32-4
14. Meena SP, Hemrajani DK, Joshi N. A comparative and evaluative study of cytological and histological grading system profile in malignant neoplasm of breast – an important prognostic factor. Indian J Pathol Microbiol 2006;49:199-202.
15. Das AK, Kapila K, Dinda AK, Verma K. Comparative evaluation of grading of breast carcinomas in fine needle aspirates by two methods. Indian J Med Res 2003;118:247-50.
Published
2020-07-27
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