Histopathological Association of Adenomyosis with Various Gynaecological Pathologies
Keywords:
Adenomyosis, Abnormal uterine bleeding, endometrium
Abstract
Objective: To study the histopathological pattern of endometrium and associated pathological conditions in patients presenting with abnormal uterine bleeding due to adenomyosis. Material and Methods: The study was conducted at Maulana Azad Medical College, New Delhi and included 87 patients who underwent hysterectomy and were diagnosed with adenomyosis from Jan 2017 to Dec 2019. These cases were subsequently reviewed for presenting symptoms of adenomyosis and correlated with histomorphological features and associated comorbidities. The quantitative variables were expressed as mean and qualitative variables as percentages. Results and Conclusion : The age of the patients who had adenomyosis ranged from 25 to 65 years, majority were in the age group of 40- 50 years. Abnormal uterine bleeding was the most common symptom. The associated histopathological examination reveals pattern of endometrium from proliferative endometrium to endometrial hyperplasia. Estrogen may be a risk factor as it is associated with fibroid and endometrial hyperplasia.References
1. Brucker SY, Huebner M, Wallwiener M, Stewart EA, Ebersoll S,Schoenfisch B et al. Clinical characteristics indicating adenomyosis coexisting with leiomyomas: A retrospective questionnaire based study. Fertil Steril 2014;101:237-41.
2. Arunachalam B, Manivasakan J. A clinicopathological study of adenomyosis. J Clin Diagn Res. 2012;6:428-30.
3. Reinhold C, Tafazoli F, Wang L. Imaging features of adenomyosis. Hum Reprod Update. 1998;4:337-49.
4. Bergholt T, Eriksen L, Berendt N, Jacobsen M, Hertz JB. Prevalence and risk factors of adenomyosis at hysterectomy. Hum Reprod. 2001;16:2418-21.
5. Parazzini F, Vercellini P, Panazza S, Chatenoud L, Oldani S, Crosignani PG. Risk factors for adenomyosis. Hum Reprod.1997;12:1275-9.
6. Vavilis D, Agorastos T, Tzafetas J, Loufopoulos A, Vakiani M, Constantinidis T et al. Adenomyosis at hysterectomy: Prevalence and relationship to operative findings and reproductive and menstrual factors. Clin Exp Obstet Gynecol. 1972;24:36-8.
7. Bird CC, McElin TW, Manalo Estrella P. The elusive adenomyosis of the uterus-revisited. Am J Obstet Gynecol.1972;112:583-93.
8. Sun YL, Wang CB, Lee CY et al. Transvaginal sonographic criteria for the diagnosis of adenomyosis based on histopathologic correlation. Taiwan J Obstet Gynecol. 2010;49(1):40-4.
9. Taran FA, Stewart EA, Brucker S. Adenomyosis: Epidemiology, Risk Factors, Clinical Phenotype and Surgical and Interventional Alternatives to Hysterectomy. Geburtshilfe Frauenheilkd. 2013;73(9):924-31.
10. Shivananjiah C, Nayak A, Swarup A, Honappa S, Swaminathan KR, Pathadan DS. Histopathological pattern of endometrium in Adenomyosis. Indian Journal of Obstetrics and Gynecology Research.2016;3(2):101-3
11. Ali A. The incidence of adenomyosis in hysterectomies. Pak J Med Res.2005;44: 38-40
12. Graziano A, Lo Monte G, Piva I et al. Diagnostic findings in adenomyosis: a pictorial review on the major concerns. Eur Rev Med Pharmac Sci. 2015;19(7):1146-54
13. Dayal S, Nagrath A. Pattern and frequency of endometrial and ovarian pathologies with adenomyosis uteri in patients who attended the tertiary care hospital among rural population of North India. MAC Journal of Medical Sciences. 2015;1(3):147-50
14. Parazzini F, Mais V, Cipriani S, Busacca M, Venturini P. Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: Results from a prospective multicentric study in Italy. Eur J Obstet Gynecol Reprod Biol. 2009;143:103- 6.
15. Verit FF, Yucel O. Endometriosis, Leiomyoma and Adenomyosis: the risk of gynecologic malignancy. Asian Pac J Cancer Prev. 2013;14(10):5589-97.
16. Horng HC, Chen CH, Chen CY et al. Uterine-sparing surgery for adenomyosis and/or adenomyoma. Taiwan J Obstet Gynecol. 2014;53(1):3-7.
17. Shu S, Luo X, Wang Z et al. Fifteen cases clinical analysis of wedge-shaped resection of uterus treating adenomyosis – CONSORT. Medicine. 2016;95(24):e3805.
2. Arunachalam B, Manivasakan J. A clinicopathological study of adenomyosis. J Clin Diagn Res. 2012;6:428-30.
3. Reinhold C, Tafazoli F, Wang L. Imaging features of adenomyosis. Hum Reprod Update. 1998;4:337-49.
4. Bergholt T, Eriksen L, Berendt N, Jacobsen M, Hertz JB. Prevalence and risk factors of adenomyosis at hysterectomy. Hum Reprod. 2001;16:2418-21.
5. Parazzini F, Vercellini P, Panazza S, Chatenoud L, Oldani S, Crosignani PG. Risk factors for adenomyosis. Hum Reprod.1997;12:1275-9.
6. Vavilis D, Agorastos T, Tzafetas J, Loufopoulos A, Vakiani M, Constantinidis T et al. Adenomyosis at hysterectomy: Prevalence and relationship to operative findings and reproductive and menstrual factors. Clin Exp Obstet Gynecol. 1972;24:36-8.
7. Bird CC, McElin TW, Manalo Estrella P. The elusive adenomyosis of the uterus-revisited. Am J Obstet Gynecol.1972;112:583-93.
8. Sun YL, Wang CB, Lee CY et al. Transvaginal sonographic criteria for the diagnosis of adenomyosis based on histopathologic correlation. Taiwan J Obstet Gynecol. 2010;49(1):40-4.
9. Taran FA, Stewart EA, Brucker S. Adenomyosis: Epidemiology, Risk Factors, Clinical Phenotype and Surgical and Interventional Alternatives to Hysterectomy. Geburtshilfe Frauenheilkd. 2013;73(9):924-31.
10. Shivananjiah C, Nayak A, Swarup A, Honappa S, Swaminathan KR, Pathadan DS. Histopathological pattern of endometrium in Adenomyosis. Indian Journal of Obstetrics and Gynecology Research.2016;3(2):101-3
11. Ali A. The incidence of adenomyosis in hysterectomies. Pak J Med Res.2005;44: 38-40
12. Graziano A, Lo Monte G, Piva I et al. Diagnostic findings in adenomyosis: a pictorial review on the major concerns. Eur Rev Med Pharmac Sci. 2015;19(7):1146-54
13. Dayal S, Nagrath A. Pattern and frequency of endometrial and ovarian pathologies with adenomyosis uteri in patients who attended the tertiary care hospital among rural population of North India. MAC Journal of Medical Sciences. 2015;1(3):147-50
14. Parazzini F, Mais V, Cipriani S, Busacca M, Venturini P. Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: Results from a prospective multicentric study in Italy. Eur J Obstet Gynecol Reprod Biol. 2009;143:103- 6.
15. Verit FF, Yucel O. Endometriosis, Leiomyoma and Adenomyosis: the risk of gynecologic malignancy. Asian Pac J Cancer Prev. 2013;14(10):5589-97.
16. Horng HC, Chen CH, Chen CY et al. Uterine-sparing surgery for adenomyosis and/or adenomyoma. Taiwan J Obstet Gynecol. 2014;53(1):3-7.
17. Shu S, Luo X, Wang Z et al. Fifteen cases clinical analysis of wedge-shaped resection of uterus treating adenomyosis – CONSORT. Medicine. 2016;95(24):e3805.
Published
2020-06-02
Issue
Section
Original Article
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
