Platelet Counts and Indices Are Altered in Pre-Eclampsia
Keywords:
Pre-eclampsia, thrombocytopenia, platelet indices, MPV, platelet distribution width, P-LCR
Abstract
BACKGROUND: Endothelial damage and activation of platelets leading to their increased consumption and increase in production of young platelets by bone marrow is the most common pathophysiology of pre-eclampsia. Thus, fall in platelet count and altered platelet indices may have diagnostic as well as prognostic value in pre-eclampsia. AIM: To evaluate platelet count and platelet indices between pre-eclamptic and normotensive women and to assess their association with severity of pre-eclampsia. METHODS: Platelet counts and indices were estimated in 30 normotensive and 30 PE women at 20-24 weeks pregnancy and were repeated after every 4 weeks. RESULTS: Mean platelet counts, platelet volume, platelet distribution width, and platelet large cell ratio between pre-eclampsia and normotensive women were significantly altered in PE women and were associated with severity of PE. This alteration of platelet count and indices occurred even before the rise of BP. CONCLUSION: All the platelet indices were found to be reliable markers of PE and were found to be increased much earlier than BP. MPV had the maximum sensitivity (96.7%) and specificity (93.3%) and was the most reliable biomarker.References
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https://doi.org/10.2147/VHRM.S120944
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13. Dadhich S, Agrawal S, Soni M, Choudhary R, Jain R, Sharma S, et al. Predictive value of platelet indices in development of preeclampsia. J SAFOG. 2012; 4(1):17–21.
14. Altınbas, Z.T. Burak. Increased MPV Is Not a Significant Predictor for Preeclampsia During Pregnancy. J Clin Lab Anal, 26 (5) (2012), pp. 403-406
15. Singh A, Varma R. Role of Platelet Distribution Width (PDW) and Plateletcrit in the Assessment of Nonthrombocytopenic Preeclampsia and Eclampsia. J Obstet Gynaecol India. 2018 Aug;68(4):289-293.
16. Thalor N, Singh K, Pujan M, Chauhan V, Agarwal C. Ahuja R. A correlation between platelet indices and preeclampsia. Hematology, Transfusion and Cell Therapy. 2019; 41 (2): 129-133
17. Sitotaw C, Asrie F, Melku M. Evaluation of platelet and white cell parameters among pregnant women with Preeclampsia in Gondar, Northwest Ethiopia: A comparative cross-sectional study. Pregnancy Hypertens. 2018;13:242-247.
18. Karateke A, Kurt RK, Baloğlu A. Relation of platelet distribution width (PDW) and platelet crit (PCT) to preeclampsia. Ginekol Pol. 2015; 86(5):372-5.
2. Gupta A, Hak J, Sunil I, and Gupta A. Platelet count estimation: a prognostic index in pregnancy induced hypertension. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2018; 7 ( 2 ): 476-482.
3. AlSheeha MA, Alaboudi RS, Alghasham MA, Iqbal J, Adam I. Platelet count and platelet indices in women with preeclampsia. Vasc Health Risk Manag. 2016;12: 477-480
https://doi.org/10.2147/VHRM.S120944
4. Gupta A, Gaur BS, Mishra KB, Dubey I. A comparison of platelet count in severe preeclampsia, mild preeclampsia and normal pregnancy. International Journal of Research in Medical Sciences. 2018; 6(2): 671-676
5. Annam V, Kendhaiah S,Yatnatti SK, Suresh DR. Evaluation of platelet indices and platelet counts and their significance in preeclampsia and eclampsia. Int J Bio Med Re. 2011; 2 (1): 425-28.
6. Sowmya K, Smitha K, Malathi T, Shivalingaiah N, Kanmani R. Platelet Count–A Prognostic Factor for Preeclampsia. Medical Science. 2015 Apr;4(4): 380-382
7. Ceyhan T, Beyan C, Başer I, Kaptan K, Güngör S, Ifran A.The effect of pre-eclampsia on complete blood count, platelet count and mean platelet volume. Ann Hematol. 2006; 85(5): 320-2.
8. McCrae KR. Thrombocytopenia in pregnancy. Hematology 2010, the American Society of Hematology Education Program Book. 2010; 2010 (1): 397-402.
9. Freitas LG, Alpoim PN, Komatsuzaki F, Carvalho MG and Dusse LMS. Preeclampsia: Are platelet count and indices useful for its prognostic? Hematology. 2013; 18:6, 360-364.
10. Tesfay F, Negash M, Alemu J, Yahya M, Teklu G, Yibrah M, et al. Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia. PLoS ONE. 2019; 14(11): e0225536.
11. Vilchez G, Lagos M, Kumar K, Argoti P. Is mean platelet volume a better biomarker in pre-eclampsia? J Obstet Gynaecol Res. 2017; 43(6): 982-990.
12. Bellos I, Fitrou G, Pergialiotis V, Papantoniou N, Daskalakis G. Mean platelet volume values in preeclampsia: A systematic review and meta-analysis. Pregnancy Hypertens. 2018; 13:174-180.
13. Dadhich S, Agrawal S, Soni M, Choudhary R, Jain R, Sharma S, et al. Predictive value of platelet indices in development of preeclampsia. J SAFOG. 2012; 4(1):17–21.
14. Altınbas, Z.T. Burak. Increased MPV Is Not a Significant Predictor for Preeclampsia During Pregnancy. J Clin Lab Anal, 26 (5) (2012), pp. 403-406
15. Singh A, Varma R. Role of Platelet Distribution Width (PDW) and Plateletcrit in the Assessment of Nonthrombocytopenic Preeclampsia and Eclampsia. J Obstet Gynaecol India. 2018 Aug;68(4):289-293.
16. Thalor N, Singh K, Pujan M, Chauhan V, Agarwal C. Ahuja R. A correlation between platelet indices and preeclampsia. Hematology, Transfusion and Cell Therapy. 2019; 41 (2): 129-133
17. Sitotaw C, Asrie F, Melku M. Evaluation of platelet and white cell parameters among pregnant women with Preeclampsia in Gondar, Northwest Ethiopia: A comparative cross-sectional study. Pregnancy Hypertens. 2018;13:242-247.
18. Karateke A, Kurt RK, Baloğlu A. Relation of platelet distribution width (PDW) and platelet crit (PCT) to preeclampsia. Ginekol Pol. 2015; 86(5):372-5.
Published
2020-07-30
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Section
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